CA2086327A1 - Clonage et production de recombinant du ou des recepteurs de la superfamille de l'activine/tgf-.beta. - Google Patents

Clonage et production de recombinant du ou des recepteurs de la superfamille de l'activine/tgf-.beta.

Info

Publication number: CA2086327A1
Authority: CA; Canada
Prior art keywords: receptor; sequence; activin; protein; leu
Prior art date: 1991-05-10
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002086327A

Other languages

English (en)

Inventor

Lawrence S. Mathews

Wylie W. Vale

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Salk Institute for Biological Studies

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-05-10

Filing date

1992-05-08

Publication date

1992-11-11

1992-05-08 Application filed by Individual filed Critical Individual

1992-11-11 Publication of CA2086327A1 publication Critical patent/CA2086327A1/fr

Status Abandoned legal-status Critical Current

Links

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239000013600 plasmid vector Substances 0.000 description 1
229920002401 polyacrylamide Polymers 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
239000002243 precursor Substances 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
230000037452 priming Effects 0.000 description 1
230000008569 process Effects 0.000 description 1
230000035755 proliferation Effects 0.000 description 1
108010015796 prolylisoleucine Proteins 0.000 description 1
108010090894 prolylleucine Proteins 0.000 description 1
108010053725 prolylvaline Proteins 0.000 description 1
108010005709 protein kinase C kinase Proteins 0.000 description 1
230000017854 proteolysis Effects 0.000 description 1
238000000746 purification Methods 0.000 description 1
230000002285 radioactive effect Effects 0.000 description 1
238000003127 radioimmunoassay Methods 0.000 description 1
238000003259 recombinant expression Methods 0.000 description 1
230000009467 reduction Effects 0.000 description 1
230000002829 reductive effect Effects 0.000 description 1
230000008929 regeneration Effects 0.000 description 1
238000011069 regeneration method Methods 0.000 description 1
230000010076 replication Effects 0.000 description 1
230000001850 reproductive effect Effects 0.000 description 1
210000004994 reproductive system Anatomy 0.000 description 1
238000011160 research Methods 0.000 description 1
230000001177 retroviral effect Effects 0.000 description 1
238000013391 scatchard analysis Methods 0.000 description 1
230000007017 scission Effects 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
108010048818 seryl-histidine Proteins 0.000 description 1
229910052709 silver Inorganic materials 0.000 description 1
239000004332 silver Substances 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
230000000365 steroidogenetic effect Effects 0.000 description 1
230000004936 stimulating effect Effects 0.000 description 1
230000000638 stimulation Effects 0.000 description 1
238000010254 subcutaneous injection Methods 0.000 description 1
239000007929 subcutaneous injection Substances 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
239000000758 substrate Substances 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
230000004083 survival effect Effects 0.000 description 1
ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 1
230000014621 translational initiation Effects 0.000 description 1
102000027257 transmembrane receptors Human genes 0.000 description 1
108091008578 transmembrane receptors Proteins 0.000 description 1
230000032258 transport Effects 0.000 description 1
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
210000004881 tumor cell Anatomy 0.000 description 1
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
108010020532 tyrosyl-proline Proteins 0.000 description 1
108010003137 tyrosyltyrosine Proteins 0.000 description 1
230000003612 virological effect Effects 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/23—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a GST-tag
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Cell Biology (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Confectionery (AREA)

CA002086327A 1991-05-10 1992-05-08 Clonage et production de recombinant du ou des recepteurs de la superfamille de l'activine/tgf-.beta. Abandoned CA2086327A1 (fr)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date
US69870991A	1991-05-10	1991-05-10
US698,709		1991-05-10
US77322991A	1991-10-09	1991-10-09
US773,229		1991-10-09

Publications (1)

Publication Number	Publication Date
CA2086327A1 true CA2086327A1 (fr)	1992-11-11

Family

ID=27106268

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002086327A Abandoned CA2086327A1 (fr)	1991-05-10	1992-05-08	Clonage et production de recombinant du ou des recepteurs de la superfamille de l'activine/tgf-.beta.

Country Status (5)

Country	Link
EP (1)	EP0542971A1 (fr)
JP (1)	JPH06500574A (fr)
AU (1)	AU654724B2 (fr)
CA (1)	CA2086327A1 (fr)
WO (1)	WO1992020793A1 (fr)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6150328A (en)	1986-07-01	2000-11-21	Genetics Institute, Inc.	BMP products
US5831050A (en) *	1993-06-07	1998-11-03	Creative Biomolecules, Inc.	Morphogen cell surface receptor
US6291206B1 (en)	1993-09-17	2001-09-18	Genetics Institute, Inc.	BMP receptor proteins
GB2289677A (en) *	1993-12-06	1995-11-29	Pna Diagnostics As	Labelling of nucleic acid analogue-peptide chimerae
DE69434651T2 (de)	1993-12-07	2007-03-08	Genetics Institute, Inc., Cambridge	Bmp-12, bmp-13 und diese enthaltende sehne-induzierende zusammensetzungen
FR2720069A1 (fr) *	1994-05-19	1995-11-24	Inst Nat Sante Rech Med	Dérivés de facteurs de croissance et d'hormones de la superfamille des TGFB, procédé pour leur obtention et leurs applications biologiques.
US5545616A (en) *	1994-09-22	1996-08-13	Genentech, Inc.	Method for predicting and/or preventing preterm labor
WO1996011259A1 (fr) *	1994-10-05	1996-04-18	Human Genome Sciences, Inc.	ACTIVINE 1 ET ACTIVINE 3, DE LA FAMILLE DES RECEPTEURS DU FACTEUR TRANSFORMANT DE CROISSANCE TGF-β1
US6210899B1 (en)	1994-11-04	2001-04-03	The Procter & Gamble Company	Use of a BMP protein receptor complex for screening bone metabolism actives and cells co-transfected with a type II BMP receptor and type I BMP receptor
US6306622B1 (en)	1994-11-04	2001-10-23	The Procter & Gamble Co.	cDNA encoding a BMP type II receptor
US5866323A (en)	1995-04-07	1999-02-02	Case Western Reserve University	Cancer diagnosis prognosis and therapy based on mutation of receptors for transforming growth factor β and homologous growth controlling factors
EP0845006A2 (fr) *	1995-08-14	1998-06-03	Creative Biomolecules, Inc.	Liaison de la proteine oestrogene 1 (op-1) et de ses analogues avec le recepteur alk-1 de surface de cellule et ses analogues
EP0771873A3 (fr) *	1995-10-27	1998-03-04	Takeda Chemical Industries, Ltd.	Protéine réceptrice neuronale à activité cellulaire
KR20000064752A (ko)	1996-03-22	2000-11-06	더 제네랄 호스피탈 코포레이션	중추신경계허혈또는외상의발현후폴리펩티드성장인자를투여하는방법
ES2146552B1 (es) *	1998-11-24	2001-04-16	Inst Cientifico Tecnol Navarra	Peptidos inhibidores de tgf/31
US6727224B1 (en)	1999-02-01	2004-04-27	Genetics Institute, Llc.	Methods and compositions for healing and repair of articular cartilage
PT1223990E (pt)	1999-10-15	2004-12-31	Fidia Advanced Biopolymers Srl	Formulacoes de acido hialuronico para administracao de proteinas osteogenicas
EP1399023B1 (fr)	2001-06-01	2008-04-30	Wyeth	Compositions pour l'administration systemique de sequences codant pour des proteines morphogenetiques osseuses
TWI267378B (en)	2001-06-08	2006-12-01	Wyeth Corp	Calcium phosphate delivery vehicles for osteoinductive proteins
EP1771470B1 (fr)	2004-07-23	2013-06-26	Acceleron Pharma Inc.	Polypeptides du recepteur actrii, procedes et compositions correspondants
KR20190006086A (ko)	2005-11-23	2019-01-16	악셀레론 파마 인코포레이티드	액티빈-ａｃｔｒⅱａ 길항제 및 골 성장을 촉진하기 위한 이들의 용도
US8128933B2 (en)	2005-11-23	2012-03-06	Acceleron Pharma, Inc.	Method of promoting bone growth by an anti-activin B antibody
US7582609B2 (en)	2006-03-01	2009-09-01	Digna Biotech, S.L.	Method for the treatment of skin fibrosis and suitable compositions for such treatment
US8895016B2 (en)	2006-12-18	2014-11-25	Acceleron Pharma, Inc.	Antagonists of activin-actriia and uses for increasing red blood cell levels
DK2124999T3 (da)	2006-12-18	2013-01-14	Acceleron Pharma Inc	Activin-actrii antagonister og anvendelser til behandling af anæmi
EP2111229B1 (fr)	2007-02-01	2013-04-10	Acceleron Pharma, Inc.	Compositions comprenant des antagonistes Activin-ActRIIA pour leur utilisation dans la prévention ou le traitement de la métastases du cancer du sein ou de la perte osseuse due au cancer du sein
TWI782836B (zh)	2007-02-02	2022-11-01	美商艾瑟勒朗法瑪公司	衍生自ActRIIB的變體與其用途
ES2756725T3 (es)	2007-02-09	2020-04-27	Acceleron Pharma Inc	Composiciones farmacéuticas que comprenden antagonistas de Activina-ActRIIA
EP3243524A1 (fr)	2007-09-18	2017-11-15	Acceleron Pharma Inc.	Antagonistes de l'activine-actriia et utilisations pour réduire ou empêcher la sécrétion de fsh
SMT202300222T1 (it)	2008-08-14	2023-09-06	Acceleron Pharma Inc	Trappole di gdf
US8216997B2 (en)	2008-08-14	2012-07-10	Acceleron Pharma, Inc.	Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators
US8138142B2 (en)	2009-01-13	2012-03-20	Acceleron Pharma Inc.	Methods for increasing adiponectin in a patient in need thereof
BRPI1010587A2 (pt)	2009-06-08	2019-04-09	Acceleron Pharma Inc.	métodos para aumentar adipócitos termogênicos
EP2440577A4 (fr)	2009-06-12	2013-01-23	Acceleron Pharma Inc	Protéines de fusion actriib-fc tronquées
JP6267425B2 (ja)	2009-11-17	2018-01-24	アクセルロンファーマ，インコーポレイテッド	筋ジストロフィー治療のためのユートロフィン誘導に関するａｃｔｒｉｉｂタンパク質およびその改変体およびその使用
CN103298832A (zh)	2010-11-08	2013-09-11	阿塞勒隆制药公司	Actriia结合剂及其用途
NZ707477A (en)	2012-11-02	2019-09-27	Celgene Corp	Activin-actrii antagonists and uses for treating bone and other disorders
WO2015192111A1 (fr)	2014-06-13	2015-12-17	Acceleron Pharma, Inc.	Méthodes et compositions de traitement d'ulcères
MA41052A (fr)	2014-10-09	2017-08-15	Celgene Corp	Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii
JP2018501307A (ja)	2014-12-03	2018-01-18	セルジーンコーポレイション	アクチビン−ＡｃｔＲＩＩアンタゴニスト及び貧血を治療するための使用

1992
- 1992-05-08 JP JP5500091A patent/JPH06500574A/ja active Pending
- 1992-05-08 EP EP92911997A patent/EP0542971A1/fr not_active Withdrawn
- 1992-05-08 CA CA002086327A patent/CA2086327A1/fr not_active Abandoned
- 1992-05-08 WO PCT/US1992/003825 patent/WO1992020793A1/fr not_active Ceased
- 1992-05-08 AU AU19945/92A patent/AU654724B2/en not_active Ceased

Also Published As

Publication number	Publication date
AU1994592A (en)	1992-12-30
EP0542971A1 (fr)	1993-05-26
AU654724B2 (en)	1994-11-17
WO1992020793A1 (fr)	1992-11-26
JPH06500574A (ja)	1994-01-20

Legal Events

Date	Code	Title	Description
1999-04-20	EEER	Examination request
2003-05-08	FZDE	Dead

Publication	Publication Date	Title
CA2086327A1 (fr)	1992-11-11	Clonage et production de recombinant du ou des recepteurs de la superfamille de l'activine/tgf-.beta.
US5885794A (en)	1999-03-23	Recombinant production of vertebrate activin receptor polypeptides and identification of receptor DNAs in the activin/TGF-β superfamily
US6835544B2 (en)	2004-12-28	Methods of screening for compounds that bind to activin receptor
US7893213B2 (en)	2011-02-22	Antibodies to activin receptor
CA2069900C (fr)	2004-07-27	Segment d'adn codant un gene pour un recepteur lie au recepteur des facteurs de croissance epidermique
HU215581B (hu)	1999-01-28	Eljárás fibroblaszt növekedési faktor receptorok előállítására és terápiás alkalmazására
JPH10179178A (ja)	1998-07-07	ヒト７回膜貫通型レセプター
JPH11502420A (ja)	1999-03-02	哺乳動物ケモカインｃｃｆ８およびケモカインレセプターｃｃｋｒ３
AU735794B2 (en)	2001-07-12	Don-1 gene and polypeptides and uses therefor
JP2003523179A (ja)	2003-08-05	哺乳動物レセプタータンパク質；関連する試薬および方法
WO1997032020A9 (fr)	1998-03-05	Proteines shc
WO1998007736A9 (fr)	1998-05-14	Gene don-1, polypeptides et utilisations de ceux-ci
US6306622B1 (en)	2001-10-23	cDNA encoding a BMP type II receptor
US7105290B2 (en)	2006-09-12	Use of a BMP protein receptor complex for screening bone metabolism actives and cells co-transfected with a type II BMP receptor and a type I BMP receptor
Kaneko et al.	2003	Interaxonal Eph-ephrin signaling may mediate sorting of olfactory sensory axons in Manduca sexta
US5882926A (en)	1999-03-16	Excitatory amino acid transporter gene and uses
Park et al.	1997	The Eek receptor, a member of the Eph family of tyrosine protein kinases, can be activated by three different Eph family ligands
AU748167B2 (en)	2002-05-30	Novel nucleic acid and polypeptide
US20020137168A1 (en)	2002-09-26	Developmental tyrosine kinases and their ligands
AU2005250185A1 (en)	2005-12-15	Splice variant of UNC5H2
US6124434A (en)	2000-09-26	Signal mediator protein that induces cellular morphological alterations
US20020127594A1 (en)	2002-09-12	Don-1 gene and polypeptides and uses therefor
AU665601B2 (en)	1996-01-11	CDNAs encoding the gastrin and CCK-B receptors
US20030119024A1 (en)	2003-06-26	Genes and proteins associated with T cell activation
Hornby	1999	Radioligand binding analyses of the group III metabotropic glutamate receptors