CA2087545A1 - Proteines dimeres de la surface cellulaire solubilisees - Google Patents

Proteines dimeres de la surface cellulaire solubilisees

Info

Publication number: CA2087545A1
Authority: CA; Canada
Prior art keywords: protein; surface membrane; cell; lipid; soluble
Prior art date: 1990-07-19
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002087545A

Other languages

English (en)

Inventor

Mark M. Davis

Augustine Lin

Brigitte Devaux

John Elliott

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Leland Stanford Junior University

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-07-19

Filing date

1991-07-18

Publication date

1992-01-20

1991-07-18 Application filed by Individual filed Critical Individual

1992-01-20 Publication of CA2087545A1 publication Critical patent/CA2087545A1/fr

Status Abandoned legal-status Critical Current

Links

108090000623 proteins and genes Proteins 0.000 title claims abstract description 92
102000004169 proteins and genes Human genes 0.000 title claims abstract description 65
210000004027 cell Anatomy 0.000 title claims description 66
108010052285 Membrane Proteins Proteins 0.000 claims abstract description 46
102000018697 Membrane Proteins Human genes 0.000 claims abstract description 26
239000012528 membrane Substances 0.000 claims abstract description 13
108091008874 T cell receptors Proteins 0.000 claims description 43
102000016266 T-Cell Antigen Receptors Human genes 0.000 claims description 41
150000002632 lipids Chemical class 0.000 claims description 21
108010076504 Protein Sorting Signals Proteins 0.000 claims description 12
238000000034 method Methods 0.000 claims description 12
150000003905 phosphatidylinositols Chemical class 0.000 claims description 12
150000001413 amino acids Chemical class 0.000 claims description 11
108020004414 DNA Proteins 0.000 claims description 7
230000001086 cytosolic effect Effects 0.000 claims description 6
108091005804 Peptidases Proteins 0.000 claims description 5
102000035195 Peptidases Human genes 0.000 claims description 5
108010059712 Pronase Proteins 0.000 claims description 4
235000019833 protease Nutrition 0.000 claims description 4
125000003275 alpha amino acid group Chemical group 0.000 claims description 3
238000003776 cleavage reaction Methods 0.000 claims description 3
230000007017 scission Effects 0.000 claims description 3
108091028043 Nucleic acid sequence Proteins 0.000 claims 4
210000003527 eukaryotic cell Anatomy 0.000 claims 1
102000035118 modified proteins Human genes 0.000 abstract 1
108091005573 modified proteins Proteins 0.000 abstract 1
125000001095 phosphatidyl group Chemical group 0.000 abstract 1
235000018102 proteins Nutrition 0.000 description 52
235000001014 amino acid Nutrition 0.000 description 11
239000000499 gel Substances 0.000 description 11
239000000539 dimer Substances 0.000 description 10
239000000178 monomer Substances 0.000 description 8
238000010186 staining Methods 0.000 description 8
101000620880 Homo sapiens Tartrate-resistant acid phosphatase type 5 Proteins 0.000 description 7
101000730535 Morganella morganii Major phosphate-irrepressible acid phosphatase Proteins 0.000 description 7
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 7
239000000872 buffer Substances 0.000 description 7
238000002703 mutagenesis Methods 0.000 description 7
231100000350 mutagenesis Toxicity 0.000 description 7
102100022919 Tartrate-resistant acid phosphatase type 5 Human genes 0.000 description 6
MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 6
239000000833 heterodimer Substances 0.000 description 6
230000003993 interaction Effects 0.000 description 6
101710139410 1-phosphatidylinositol phosphodiesterase Proteins 0.000 description 5
102000004190 Enzymes Human genes 0.000 description 5
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102100037097 Protein disulfide-isomerase A3 Human genes 0.000 description 5
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125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 4
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239000003446 ligand Substances 0.000 description 4
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 4
239000010452 phosphate Substances 0.000 description 4
238000012545 processing Methods 0.000 description 4
SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 4
239000011780 sodium chloride Substances 0.000 description 4
241000699800 Cricetinae Species 0.000 description 3
229930193140 Neomycin Natural products 0.000 description 3
VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 3
239000000427 antigen Substances 0.000 description 3
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HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical group NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 2
108091003079 Bovine Serum Albumin Proteins 0.000 description 2
108010009575 CD55 Antigens Proteins 0.000 description 2
108020004635 Complementary DNA Proteins 0.000 description 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
241000829100 Macaca mulatta polyomavirus 1 Species 0.000 description 2
108700018351 Major Histocompatibility Complex Proteins 0.000 description 2
IOVCWXUNBOPUCH-UHFFFAOYSA-N Nitrous acid Chemical compound ON=O IOVCWXUNBOPUCH-UHFFFAOYSA-N 0.000 description 2
108091034117 Oligonucleotide Proteins 0.000 description 2
BELBBZDIHDAJOR-UHFFFAOYSA-N Phenolsulfonephthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2S(=O)(=O)O1 BELBBZDIHDAJOR-UHFFFAOYSA-N 0.000 description 2
239000006146 Roswell Park Memorial Institute medium Substances 0.000 description 2
108091006629 SLC13A2 Proteins 0.000 description 2
BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 2
229960000723 ampicillin Drugs 0.000 description 2
AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 2
210000003719 b-lymphocyte Anatomy 0.000 description 2
230000003115 biocidal effect Effects 0.000 description 2
238000010367 cloning Methods 0.000 description 2
230000000295 complement effect Effects 0.000 description 2
ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 description 2
125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 2
238000010828 elution Methods 0.000 description 2
239000012894 fetal calf serum Substances 0.000 description 2
239000001963 growth medium Substances 0.000 description 2
239000000710 homodimer Substances 0.000 description 2
229940072221 immunoglobulins Drugs 0.000 description 2
238000005304 joining Methods 0.000 description 2
239000002609 medium Substances 0.000 description 2
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229960003531 phenolsulfonphthalein Drugs 0.000 description 2
239000013612 plasmid Substances 0.000 description 2
230000008488 polyadenylation Effects 0.000 description 2
229920001184 polypeptide Polymers 0.000 description 2
239000002243 precursor Substances 0.000 description 2
102000004196 processed proteins & peptides Human genes 0.000 description 2
239000000047 product Substances 0.000 description 2
XJMOSONTPMZWPB-UHFFFAOYSA-M propidium iodide Chemical compound [I-].[I-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CCC[N+](C)(CC)CC)=C1C1=CC=CC=C1 XJMOSONTPMZWPB-UHFFFAOYSA-M 0.000 description 2
108020003175 receptors Proteins 0.000 description 2
102000005962 receptors Human genes 0.000 description 2
230000004044 response Effects 0.000 description 2
229910052709 silver Inorganic materials 0.000 description 2
239000004332 silver Substances 0.000 description 2
229910001961 silver nitrate Inorganic materials 0.000 description 2
239000000243 solution Substances 0.000 description 2
239000006228 supernatant Substances 0.000 description 2
230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 description 2
230000009258 tissue cross reactivity Effects 0.000 description 2
230000005945 translocation Effects 0.000 description 2
BRZYSWJRSDMWLG-DJWUNRQOSA-N (2r,3r,4r,5r)-2-[(1s,2s,3r,4s,6r)-4,6-diamino-3-[(2s,3r,4r,5s,6r)-3-amino-4,5-dihydroxy-6-[(1r)-1-hydroxyethyl]oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H]([C@@H](C)O)O2)N)[C@@H](N)C[C@H]1N BRZYSWJRSDMWLG-DJWUNRQOSA-N 0.000 description 1
QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 description 1
102000002260 Alkaline Phosphatase Human genes 0.000 description 1
108020004774 Alkaline Phosphatase Proteins 0.000 description 1
102100024321 Alkaline phosphatase, placental type Human genes 0.000 description 1
208000002109 Argyria Diseases 0.000 description 1
108010012919 B-Cell Antigen Receptors Proteins 0.000 description 1
102000019260 B-Cell Antigen Receptors Human genes 0.000 description 1
101100481176 Bacillus subtilis (strain 168) thiE gene Proteins 0.000 description 1
101710125089 Bindin Proteins 0.000 description 1
125000001433 C-terminal amino-acid group Chemical group 0.000 description 1
102000005367 Carboxypeptidases Human genes 0.000 description 1
108010006303 Carboxypeptidases Proteins 0.000 description 1
102000004127 Cytokines Human genes 0.000 description 1
108090000695 Cytokines Proteins 0.000 description 1
101100494344 Desulfobacterium autotrophicum (strain ATCC 43914 / DSM 3382 / HRM2) bzaF gene Proteins 0.000 description 1
BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 1
238000012413 Fluorescence activated cell sorting analysis Methods 0.000 description 1
108091006027 G proteins Proteins 0.000 description 1
102000030782 GTP binding Human genes 0.000 description 1
108091000058 GTP-Binding Proteins 0.000 description 1
241000735445 Hetrodes Species 0.000 description 1
SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 1
102000008949 Histocompatibility Antigens Class I Human genes 0.000 description 1
108010088652 Histocompatibility Antigens Class I Proteins 0.000 description 1
102000018713 Histocompatibility Antigens Class II Human genes 0.000 description 1
108010027412 Histocompatibility Antigens Class II Proteins 0.000 description 1
241000714260 Human T-lymphotropic virus 1 Species 0.000 description 1
108091092195 Intron Proteins 0.000 description 1
102000043131 MHC class II family Human genes 0.000 description 1
108091054438 MHC class II family Proteins 0.000 description 1
241000283973 Oryctolagus cuniculus Species 0.000 description 1
241001631646 Papillomaviridae Species 0.000 description 1
206010035226 Plasma cell myeloma Diseases 0.000 description 1
101710160829 Poly(A) polymerase catalytic subunit Proteins 0.000 description 1
102000002067 Protein Subunits Human genes 0.000 description 1
240000004808 Saccharomyces cerevisiae Species 0.000 description 1
229920002684 Sepharose Polymers 0.000 description 1
241000700584 Simplexvirus Species 0.000 description 1
108010090804 Streptavidin Proteins 0.000 description 1
210000001744 T-lymphocyte Anatomy 0.000 description 1
102000014384 Type C Phospholipases Human genes 0.000 description 1
108010079194 Type C Phospholipases Proteins 0.000 description 1
INAPMGSXUVUWAF-GCVPSNMTSA-N [(2r,3s,5r,6r)-2,3,4,5,6-pentahydroxycyclohexyl] dihydrogen phosphate Chemical compound OC1[C@H](O)[C@@H](O)C(OP(O)(O)=O)[C@H](O)[C@@H]1O INAPMGSXUVUWAF-GCVPSNMTSA-N 0.000 description 1
230000009471 action Effects 0.000 description 1
238000001042 affinity chromatography Methods 0.000 description 1
238000004458 analytical method Methods 0.000 description 1
238000004873 anchoring Methods 0.000 description 1
238000000211 autoradiogram Methods 0.000 description 1
238000000376 autoradiography Methods 0.000 description 1
MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 1
239000003139 biocide Substances 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
229910000389 calcium phosphate Inorganic materials 0.000 description 1
239000001506 calcium phosphate Substances 0.000 description 1
235000011010 calcium phosphates Nutrition 0.000 description 1
210000000170 cell membrane Anatomy 0.000 description 1
230000003833 cell viability Effects 0.000 description 1
239000003153 chemical reaction reagent Substances 0.000 description 1
239000013599 cloning vector Substances 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
238000001514 detection method Methods 0.000 description 1
150000001982 diacylglycerols Chemical class 0.000 description 1
LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
238000001962 electrophoresis Methods 0.000 description 1
238000005516 engineering process Methods 0.000 description 1
108010094102 enzymobeads Proteins 0.000 description 1
238000000684 flow cytometry Methods 0.000 description 1
238000001943 fluorescence-activated cell sorting Methods 0.000 description 1
239000012634 fragment Substances 0.000 description 1
239000003862 glucocorticoid Substances 0.000 description 1
229960002442 glucosamine Drugs 0.000 description 1
150000002337 glycosamines Chemical class 0.000 description 1
210000002288 golgi apparatus Anatomy 0.000 description 1
238000004128 high performance liquid chromatography Methods 0.000 description 1
239000005556 hormone Substances 0.000 description 1
229940088597 hormone Drugs 0.000 description 1
108091008039 hormone receptors Proteins 0.000 description 1
238000009396 hybridization Methods 0.000 description 1
125000001841 imino group Chemical group [H]N=* 0.000 description 1
239000012133 immunoprecipitate Substances 0.000 description 1
238000001114 immunoprecipitation Methods 0.000 description 1
238000000338 in vitro Methods 0.000 description 1
230000005764 inhibitory process Effects 0.000 description 1
CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
229960000367 inositol Drugs 0.000 description 1
238000003780 insertion Methods 0.000 description 1
230000037431 insertion Effects 0.000 description 1
238000002955 isolation Methods 0.000 description 1
210000003292 kidney cell Anatomy 0.000 description 1
230000007774 longterm Effects 0.000 description 1
230000002101 lytic effect Effects 0.000 description 1
210000004962 mammalian cell Anatomy 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
102000006240 membrane receptors Human genes 0.000 description 1
108020004084 membrane receptors Proteins 0.000 description 1
201000000050 myeloid neoplasm Diseases 0.000 description 1
239000013642 negative control Substances 0.000 description 1
108020004707 nucleic acids Proteins 0.000 description 1
102000039446 nucleic acids Human genes 0.000 description 1
150000007523 nucleic acids Chemical class 0.000 description 1
239000002953 phosphate buffered saline Substances 0.000 description 1
108010031345 placental alkaline phosphatase Proteins 0.000 description 1
230000003169 placental effect Effects 0.000 description 1
238000003752 polymerase chain reaction Methods 0.000 description 1
238000011533 pre-incubation Methods 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
238000003825 pressing Methods 0.000 description 1
238000000746 purification Methods 0.000 description 1
230000008439 repair process Effects 0.000 description 1
238000012216 screening Methods 0.000 description 1
CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
230000003248 secreting effect Effects 0.000 description 1
239000006152 selective media Substances 0.000 description 1
238000000926 separation method Methods 0.000 description 1
238000012163 sequencing technique Methods 0.000 description 1
230000003381 solubilizing effect Effects 0.000 description 1
150000003431 steroids Chemical class 0.000 description 1
101150029215 thiC gene Proteins 0.000 description 1
230000002463 transducing effect Effects 0.000 description 1
238000010361 transduction Methods 0.000 description 1
230000026683 transduction Effects 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
241000701161 unidentified adenovirus Species 0.000 description 1
230000029812 viral genome replication Effects 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/90—Fusion polypeptide containing a motif for post-translational modification
- C07K2319/91—Fusion polypeptide containing a motif for post-translational modification containing a motif for glycosylation
- C07K2319/912—Fusion polypeptide containing a motif for post-translational modification containing a motif for glycosylation containing a GPI (phosphatidyl-inositol glycane) anchor

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Immunology (AREA)
Organic Chemistry (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Toxicology (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Cell Biology (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

CA002087545A 1990-07-19 1991-07-18 Proteines dimeres de la surface cellulaire solubilisees Abandoned CA2087545A1 (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US55511690A	1990-07-19	1990-07-19
US555,116		1990-07-19
PCT/US1991/005082 WO1992001715A1 (fr)	1990-07-19	1991-07-18	Proteines dimeres solubles de surface cellulaire

Publications (1)

Publication Number	Publication Date
CA2087545A1 true CA2087545A1 (fr)	1992-01-20

Family

ID=24216031

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002087545A Abandoned CA2087545A1 (fr)	1990-07-19	1991-07-18	Proteines dimeres de la surface cellulaire solubilisees

Country Status (2)

Country	Link
CA (1)	CA2087545A1 (fr)
WO (1)	WO1992001715A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BR9400600A (pt) *	1994-02-17	1995-10-24	Finep Financiadora De Estudos	Processos para produção de uma protéina recombinante e/ou de glicosilfosfatidilinositol (GPI) em células de microorganismos eucariontes e para a obtenção de leveduras de S. cerevisae; célula de levedura sequência de nucleotídios; meio de cultura; medicamento ou vacina; e produto dos ditos processos
WO1996013593A2 (fr) *	1994-10-26	1996-05-09	Procept, Inc.	Recepteurs de lymphocites t monocatenaires solubles
WO1996021028A2 (fr) *	1995-01-03	1996-07-11	Procept, Inc.	Recepteurs de lymphocytes t heterodimeres solubles et leurs anticorps
US7323174B1 (en)	2000-06-12	2008-01-29	Arizona Board Of Regents On Behalf Of The University Of Arizona	Modulation of immune response and methods based thereon
GB0112126D0 (en) *	2001-05-18	2001-07-11	Allergene Inc	Composition
EP1723239B1 (fr) *	2004-02-09	2009-12-09	Synamem Corporation	Production de proteines captives
US10961286B2 (en)	2014-08-15	2021-03-30	Cornell University	Nucleic acids, vectors, host cells, and methods for recombinantly producing water-soluble membrane proteins

1991
- 1991-07-18 WO PCT/US1991/005082 patent/WO1992001715A1/fr not_active Ceased
- 1991-07-18 CA CA002087545A patent/CA2087545A1/fr not_active Abandoned

Also Published As

Publication number	Publication date
WO1992001715A1 (fr)	1992-02-06

Legal Events

Date	Code	Title	Description
1995-01-18	FZDE	Discontinued

Publication	Publication Date	Title
Malergue et al.	1998	A novel immunoglobulin superfamily junctional molecule expressed by antigen presenting cells, endothelial cells and platelets
Shaw et al.	1990	Mutations of immunoglobulin transmembrane and cytoplasmic domains: effects on intracellular signaling and antigen presentation
CA2074825C (fr)	2005-04-12	Chaines chimeriques pour cheminements de signaux de recepteurs
Robinson et al.	1989	A glycophospholipid anchor is required for Qa-2-mediated T cell activation
JP3832850B2 (ja)	2006-10-11	キメラｃｄ４レセプターを有する細胞によるｈｉｖ感染細胞を標的とする細胞傷害
US20030077249A1 (en)	2003-04-24	Cell activation process and reagents therefor
EP1177292B1 (fr)	2005-12-14	Famille d'immunoregulateurs nommes recepteurs de leucocytes de type immunoglobuline (lir)
US20090202501A1 (en)	2009-08-13	Chimeric NK receptor and methods for treating cancer
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