CA2092825A1 - Implant muni de trous - Google Patents
Implant muni de trousInfo
- Publication number
- CA2092825A1 CA2092825A1 CA002092825A CA2092825A CA2092825A1 CA 2092825 A1 CA2092825 A1 CA 2092825A1 CA 002092825 A CA002092825 A CA 002092825A CA 2092825 A CA2092825 A CA 2092825A CA 2092825 A1 CA2092825 A1 CA 2092825A1
- Authority
- CA
- Canada
- Prior art keywords
- chamber
- cells
- host
- holes
- w1th
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000007943 implant Substances 0.000 title description 3
- 239000012620 biological material Substances 0.000 claims abstract 6
- 239000000560 biocompatible material Substances 0.000 claims abstract 3
- 230000035899 viability Effects 0.000 claims abstract 2
- 239000012528 membrane Substances 0.000 claims description 45
- 210000004027 cell Anatomy 0.000 claims description 41
- 239000004809 Teflon Substances 0.000 claims description 10
- 229920006362 Teflon® Polymers 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 5
- 230000001919 adrenal effect Effects 0.000 claims description 2
- 230000003248 secreting effect Effects 0.000 claims 3
- 210000002237 B-cell of pancreatic islet Anatomy 0.000 claims 1
- 102100022641 Coagulation factor IX Human genes 0.000 claims 1
- 108010076282 Factor IX Proteins 0.000 claims 1
- 108010054218 Factor VIII Proteins 0.000 claims 1
- 102000001690 Factor VIII Human genes 0.000 claims 1
- 229960004222 factor ix Drugs 0.000 claims 1
- 229960000301 factor viii Drugs 0.000 claims 1
- 210000004007 growth hormone secreting cell Anatomy 0.000 claims 1
- 239000012510 hollow fiber Substances 0.000 claims 1
- 210000004153 islets of langerhan Anatomy 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 230000000849 parathyroid Effects 0.000 claims 1
- 230000001817 pituitary effect Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 210000001685 thyroid gland Anatomy 0.000 claims 1
- 239000011148 porous material Substances 0.000 description 29
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 24
- 239000008103 glucose Substances 0.000 description 24
- 210000004369 blood Anatomy 0.000 description 23
- 239000008280 blood Substances 0.000 description 23
- 241000700159 Rattus Species 0.000 description 21
- 210000000577 adipose tissue Anatomy 0.000 description 13
- 238000007446 glucose tolerance test Methods 0.000 description 10
- 230000001605 fetal effect Effects 0.000 description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- 210000000056 organ Anatomy 0.000 description 8
- 230000001413 cellular effect Effects 0.000 description 6
- 230000002792 vascular Effects 0.000 description 6
- 102000051325 Glucagon Human genes 0.000 description 5
- 108060003199 Glucagon Proteins 0.000 description 5
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 description 5
- 229960004666 glucagon Drugs 0.000 description 5
- 210000004072 lung Anatomy 0.000 description 5
- 210000000496 pancreas Anatomy 0.000 description 5
- 230000004865 vascular response Effects 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 238000013459 approach Methods 0.000 description 3
- 210000003463 organelle Anatomy 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 210000005166 vasculature Anatomy 0.000 description 3
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 2
- 239000012980 RPMI-1640 medium Substances 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 229920000728 polyester Polymers 0.000 description 2
- 210000005239 tubule Anatomy 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- 102000029816 Collagenase Human genes 0.000 description 1
- 108060005980 Collagenase Proteins 0.000 description 1
- 241000518994 Conta Species 0.000 description 1
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 102000018997 Growth Hormone Human genes 0.000 description 1
- 108010051696 Growth Hormone Proteins 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 101150057615 Syn gene Proteins 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- BLFLLBZGZJTVJG-UHFFFAOYSA-N benzocaine Chemical compound CCOC(=O)C1=CC=C(N)C=C1 BLFLLBZGZJTVJG-UHFFFAOYSA-N 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 229960002424 collagenase Drugs 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 239000000122 growth hormone Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- -1 polypropylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000006444 vascular growth Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/022—Artificial gland structures using bioreactors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Prostheses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73763291A | 1991-07-30 | 1991-07-30 | |
| US7/737,632 | 1991-07-30 | ||
| PCT/US1992/005747 WO1993002635A1 (fr) | 1991-07-30 | 1992-07-09 | Implant foramine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2092825A1 true CA2092825A1 (fr) | 1993-01-31 |
Family
ID=24964651
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002092825A Abandoned CA2092825A1 (fr) | 1991-07-30 | 1992-07-09 | Implant muni de trous |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0555428A1 (fr) |
| JP (1) | JPH06502577A (fr) |
| CA (1) | CA2092825A1 (fr) |
| NO (1) | NO931168L (fr) |
| WO (1) | WO1993002635A1 (fr) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994018906A1 (fr) * | 1993-02-18 | 1994-09-01 | New England Deaconess Hospital, Corp. | Organe artificiel implantable |
| ATE218893T1 (de) * | 1993-08-12 | 2002-06-15 | Neurotech Sa | Biokompatible immunoisolatorische kapseln, die genetisch veränderte zellen enthalten |
| US5908623A (en) * | 1993-08-12 | 1999-06-01 | Cytotherapeutics, Inc. | Compositions and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules |
| WO1996032076A1 (fr) * | 1995-04-11 | 1996-10-17 | Baxter Internatonal Inc. | Dispositifs d'implantation tissulaire |
| EP2125056B1 (fr) * | 2007-02-19 | 2015-11-18 | Ticapex AB | Ensemble d'implant |
| AU2009313870B2 (en) | 2008-11-14 | 2013-07-11 | Viacyte, Inc. | Encapsulation of pancreatic cells derived from human pluripotent stem cells |
| JPWO2017158791A1 (ja) * | 2016-03-17 | 2019-01-17 | 株式会社Ｆｕｊｉ | 人工臓器用のセルチャンバー |
| DK3537986T3 (da) | 2016-11-10 | 2025-07-21 | Viacyte Inc | Pdx1 pankreatiske endodermceller i celleleveringsanordning |
| US12378572B2 (en) | 2018-09-07 | 2025-08-05 | Crispr Therapeutics Ag | Universal donor cells |
| KR20220058579A (ko) | 2019-09-05 | 2022-05-09 | 크리스퍼 테라퓨틱스 아게 | 보편적 공여자 세포 |
| KR20230146007A (ko) | 2020-12-31 | 2023-10-18 | 크리스퍼 테라퓨틱스 아게 | 범용 공여자 세포 |
| WO2023164171A2 (fr) | 2022-02-25 | 2023-08-31 | Viacyte, Inc. | Dispositifs d'encapsulation de cellules implantables multicouches et procédés associés |
| IL315045A (en) * | 2022-03-18 | 2024-10-01 | Polbionica Sp Z O O | A reinforcing and sealing construction for a bioprinted tissue model, and a method for assembling the reinforcing and sealing construction |
| PL74279Y1 (pl) * | 2024-03-12 | 2026-03-02 | Polbionica Spolka Z Ograniczona Odpowiedzialnoscia | Obudowa wzmacniająca i uszczelniająca biodrukowany model tkankowy |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4309776A (en) * | 1980-05-13 | 1982-01-12 | Ramon Berguer | Intravascular implantation device and method of using the same |
| CA1340581C (fr) * | 1986-11-20 | 1999-06-08 | Joseph P. Vacanti | Neomorphogenese chimerique d'organes par implatation cellulaire controlee, utilisant des matrices artificielles |
| WO1991000119A1 (fr) * | 1989-06-30 | 1991-01-10 | Baxter International Inc. | Dispositif implantable |
-
1992
- 1992-07-09 JP JP5503566A patent/JPH06502577A/ja active Pending
- 1992-07-09 CA CA002092825A patent/CA2092825A1/fr not_active Abandoned
- 1992-07-09 WO PCT/US1992/005747 patent/WO1993002635A1/fr not_active Ceased
- 1992-07-09 EP EP92915761A patent/EP0555428A1/fr not_active Withdrawn
-
1993
- 1993-03-29 NO NO93931168A patent/NO931168L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0555428A1 (fr) | 1993-08-18 |
| NO931168D0 (no) | 1993-03-29 |
| WO1993002635A1 (fr) | 1993-02-18 |
| NO931168L (no) | 1993-03-29 |
| JPH06502577A (ja) | 1994-03-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |