CA2104576C - A method for the treatment of tumours and sarcomas - Google Patents

A method for the treatment of tumours and sarcomas

Info

Publication number: CA2104576C
Authority: CA; Canada
Prior art keywords: lif; use according; mammal; tumours; human
Prior art date: 1991-12-24
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

CA002104576A

Other languages

English (en)

French (fr)

Other versions

CA2104576A1 (en

Inventor

George Kannourakis

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

CSL Innovation Pty Ltd

Original Assignee

Amrad Corp Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-12-24

Filing date

1992-12-24

Publication date

1997-04-15

1992-12-24 Application filed by Amrad Corp Ltd filed Critical Amrad Corp Ltd

1993-06-25 Publication of CA2104576A1 publication Critical patent/CA2104576A1/en

1997-04-15 Application granted granted Critical

1997-04-15 Publication of CA2104576C publication Critical patent/CA2104576C/en

2012-12-24 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2006—IL-1
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2093—Leukaemia inhibitory factor [LIF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Photoreceptors In Electrophotography (AREA)
Medicines Containing Plant Substances (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

CA002104576A 1991-12-24 1992-12-24 A method for the treatment of tumours and sarcomas Expired - Fee Related CA2104576C (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
AUPL016491		1991-12-24
AUPL0164		1991-12-24

Publications (2)

Publication Number	Publication Date
CA2104576A1 CA2104576A1 (en)	1993-06-25
CA2104576C true CA2104576C (en)	1997-04-15

Family

ID=3775908

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002104576A Expired - Fee Related CA2104576C (en)	1991-12-24	1992-12-24	A method for the treatment of tumours and sarcomas

Country Status (9)

Country	Link
US (1)	US5599789A (de)
EP (1)	EP0620736B1 (de)
JP (1)	JPH07502514A (de)
KR (1)	KR940702380A (de)
AT (1)	ATE199498T1 (de)
AU (1)	AU3251693A (de)
CA (1)	CA2104576C (de)
DE (1)	DE69231726D1 (de)
WO (1)	WO1993012806A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1994021272A1 (en) *	1993-03-17	1994-09-29	Amrad Corporation Limited	A method for treating microbial infection in an animal by administering a composition comprising lif and a cytokine
AU723610B2 (en) *	1995-10-27	2000-08-31	Walter And Eliza Hall Institute Of Medical Research, The	Cytokines and their use in treatment and/or prophylaxis of breast cancer
EP0871472A4 (de) *	1995-10-27	2001-05-30	Amrad Operations Pty Ltd	Cytokine und ihre verwendung in behandlung und/oder vorbeugung von brustkrebs
KR101338533B1 (ko) *	2005-07-19	2013-12-12	스템젠 에스.피.에이.	Ｌｉｆ 및 ｂｍｐ에 의한 종양 줄기 세포의 종양발생가능성의 억제

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS4840815A (de) *	1971-09-25	1973-06-15
JPS62112769A (ja) *	1985-11-12	1987-05-23	Tadahiro Shimazu	耐摩耗性、耐食性、耐久性に優れる容射被膜の形成方法
PT87133B (pt) *	1987-04-02	1992-07-31	Amrad Corp Ltd	Metodo de purificacao do factor inibidor da leucemia (lif) e de composicoes farmaceuticas contendo polipeptidos com actividade do lif
AU609128B2 (en) *	1987-04-02	1991-04-26	Amrad Operations Pty. Limited	Leukaemia-inhibitory factor
DE3822997A1 (de) *	1988-07-07	1990-01-18	Henkel Kgaa	Detergensmischung aus nichtionischen und anionischen tensiden und deren verwendung
CA1340748C (en) *	1988-07-13	1999-09-14	Stephen Oroszlan	Synthetic hiv protease gene and method for its expression
AU622515B2 (en) *	1989-01-10	1992-04-09	Amrad Operations Pty. Limited	Leukaemia inhibitory factor from livestock species and use thereof to enhance implantation and development of embryonic cells
AU623987B2 (en) *	1989-03-07	1992-05-28	Amrad Operations Pty. Limited	Metabolic effects of leukaemia inhibitory factor on bone
AU5958090A (en) *	1989-06-29	1991-01-17	United States of America, as represented by the Secretary, U.S. Department of Commerce, The	Method for protecting bone marrow against chemotherapeutic drugs and radiation therapy using transforming growth factor beta 1
JP3040815B2 (ja) *	1989-11-24	2000-05-15	モナッシュ・ユニバーシティ	随伴細胞に及ぼす白血病抑制因子の増殖作用
GB9004890D0 (en) *	1990-03-05	1990-05-02	Heath John K	Leukaemia inhibitory factor
AU635412B2 (en) *	1990-03-20	1993-03-18	Amrad Operations Pty. Limited	A method for regulating neuron development and maintenance

1992
- 1992-12-24 US US08/107,767 patent/US5599789A/en not_active Expired - Fee Related
- 1992-12-24 JP JP51131593A patent/JPH07502514A/ja not_active Ceased
- 1992-12-24 WO PCT/AU1992/000683 patent/WO1993012806A1/en not_active Ceased
- 1992-12-24 CA CA002104576A patent/CA2104576C/en not_active Expired - Fee Related
- 1992-12-24 KR KR1019940700854A patent/KR940702380A/ko not_active Abandoned
- 1992-12-24 AT AT93901068T patent/ATE199498T1/de active
- 1992-12-24 EP EP93901068A patent/EP0620736B1/de not_active Expired - Lifetime
- 1992-12-24 AU AU32516/93A patent/AU3251693A/en not_active Abandoned
- 1992-12-24 DE DE69231726T patent/DE69231726D1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CA2104576A1 (en)	1993-06-25
EP0620736A1 (de)	1994-10-26
EP0620736B1 (de)	2001-03-07
AU3251693A (en)	1993-07-28
ATE199498T1 (de)	2001-03-15
KR940702380A (ko)	1994-08-20
DE69231726D1 (de)	2001-04-12
JPH07502514A (ja)	1995-03-16
US5599789A (en)	1997-02-04
EP0620736A4 (en)	1995-09-06
WO1993012806A1 (en)	1993-07-08

Legal Events

Date	Code	Title	Description
1993-11-03	EEER	Examination request
2004-12-24	MKLA	Lapsed

Publication	Publication Date	Title
Witsell et al.	1992	Tumor necrosis factor alpha is an autocrine growth regulator during macrophage differentiation.
JP2688539B2 (ja)	1997-12-10	ほ乳類サイトカイン、ｉｌ―１１
Metcalf et al.	1990	Effects of injected leukemia inhibitory factor on hematopoietic and other tissues in mice
Pfeilschifter et al.	1989	Interleukin‐1 and tumor necrosis factor stimulate the formation of human osteoclastlike cells in vitro
BR112020009920A2 (pt)	2020-12-15	Agonistas parciais de interleucina-2
DE60106002T2 (de)	2006-02-02	Behandlung von hämatopoetischen Zellen mit CXCR4 Agonisten
Kitamura et al.	1987	Mutual phenotypic changes between connective tissue type and mucosal mast cells
KR19990071523A (ko)	1999-09-27	Il－8 및 il－8 수용체에 대한 안티센스올리고누클레오티드에 의한 종양 성장의 억제방법
HU219540B (hu)	2001-05-28	C-KIT receptor-ligandum és eljárás alkalmazására
Fletcher et al.	1990	Murine leukemia inhibitory factor enhances retroviral-vector infection efficiency of hematopoietic progenitors
Hawley et al.	1993	Progenitor cell hyperplasia with rare development of myeloid leukemia in interleukin 11 bone marrow chimeras.
CA2104576C (en)	1997-04-15	A method for the treatment of tumours and sarcomas
Wetzler et al.	1994	Leukemia inhibitory factor in long-term adherent layer cultures: increased levels of bioactive protein in leukemia and modulation by IL-4, IL-1β, and TNF-α
Takahashi et al.	1987	Osteoclast‐like cell formation in fetal and newborn long‐term baboon marrow cultures is more sensitive to 1, 25‐dihydroxyvitamin D3 than adult long‐term marrow cultures
CA2071956C (en)	2000-04-18	Method for the treatment of thrombocytopenia and pharmaceutical compositions useful therefor
Rogers et al.	1994	TNF-alpha inhibits the further development of committed progenitors while stimulating multipotential progenitors in mouse long-term bone marrow cultures.
Wermann et al.	1996	Human-mouse xenografts in stem cell research
Friel et al.	2002	Hierarchy of stroma-derived factors in supporting growth of stroma-dependent hemopoietic cells: membrane-bound SCF is sufficient to confer stroma competence to epithelial cells
Estrov et al.	1991	Granulocyte-macrophage colony-stimulating factor and interleukin-3 in combination: a potent and consistent myelodysplastic syndrome bone marrow stimulant in vitro
McInnes et al.	1999	THE CLONING AND EXPRESSION OF THE cDNA FOR OVINE STEM CELL FACTOR (KIT-LIGAND) AND CHARACTERIZATION OF ITSIN VITROHAEMATOPOIETIC ACTIVITY
Daniel et al.	1989	The role of growth factors in haemopoietic development: clinical and biological implications
Yu-Chung	2020	Human Interleukin-3: An Overview
Yang	1997	Human lnterleukin-3
Abboud	1995	Regulation of platelet‐derived growth factor A and B chain gene expression in bone marrow stromal cells
CA2321132A1 (en)	1999-08-26	P53-dependent secretion of growth inhibitory factors