CA2117257C - Pansement contenant de l'alginate - Google Patents

Pansement contenant de l'alginate Download PDF

Info

Publication number: CA2117257C
Authority: CA; Canada
Prior art keywords: alginate; fabric; calcium; sodium; wound
Prior art date: 1994-04-06
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

CA002117257A

Other languages

English (en)

Other versions

CA2117257A1 (fr

Inventor

Harish A. Patel

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Kendall Co

Original Assignee

Kendall Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-04-06

Filing date

1994-04-06

Publication date

2005-12-27

1994-04-06 Application filed by Kendall Co filed Critical Kendall Co

1994-04-06 Priority to CA002117257A priority Critical patent/CA2117257C/fr

1995-10-07 Publication of CA2117257A1 publication Critical patent/CA2117257A1/fr

2005-12-27 Application granted granted Critical

2005-12-27 Publication of CA2117257C publication Critical patent/CA2117257C/fr

2014-04-06 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

235000010443 alginic acid Nutrition 0.000 title claims abstract description 82
229920000615 alginic acid Polymers 0.000 title claims abstract description 82
229940072056 alginate Drugs 0.000 title claims abstract description 75
FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 title claims abstract description 74
239000002250 absorbent Substances 0.000 claims abstract description 17
230000002745 absorbent Effects 0.000 claims abstract description 17
235000010410 calcium alginate Nutrition 0.000 claims description 55
239000000648 calcium alginate Substances 0.000 claims description 53
229960002681 calcium alginate Drugs 0.000 claims description 53
OKHHGHGGPDJQHR-YMOPUZKJSA-L calcium;(2s,3s,4s,5s,6r)-6-[(2r,3s,4r,5s,6r)-2-carboxy-6-[(2r,3s,4r,5s,6r)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate Chemical compound [Ca+2].O[C@@H]1[C@H](O)[C@H](O)O[C@@H](C([O-])=O)[C@H]1O[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@H](O2)C([O-])=O)O)[C@H](C(O)=O)O1 OKHHGHGGPDJQHR-YMOPUZKJSA-L 0.000 claims description 48
235000010413 sodium alginate Nutrition 0.000 claims description 36
239000004744 fabric Substances 0.000 claims description 34
239000000661 sodium alginate Substances 0.000 claims description 34
229940005550 sodium alginate Drugs 0.000 claims description 34
239000000203 mixture Substances 0.000 claims description 30
IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 28
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 19
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 15
229910052708 sodium Inorganic materials 0.000 claims description 15
238000000034 method Methods 0.000 claims description 8
239000011734 sodium Substances 0.000 claims description 8
239000007864 aqueous solution Substances 0.000 claims description 7
239000008367 deionised water Substances 0.000 claims description 7
238000001035 drying Methods 0.000 claims description 7
239000004745 nonwoven fabric Substances 0.000 claims description 7
230000008569 process Effects 0.000 claims description 7
239000000243 solution Substances 0.000 claims description 6
239000002759 woven fabric Substances 0.000 claims description 6
UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 4
239000001110 calcium chloride Substances 0.000 claims description 4
229910001628 calcium chloride Inorganic materials 0.000 claims description 4
229910021641 deionized water Inorganic materials 0.000 claims description 4
239000012153 distilled water Substances 0.000 claims description 4
238000004519 manufacturing process Methods 0.000 claims description 4
238000005406 washing Methods 0.000 claims description 3
239000003960 organic solvent Substances 0.000 claims description 2
206010052428 Wound Diseases 0.000 abstract description 62
208000027418 Wounds and injury Diseases 0.000 abstract description 62
230000000025 haemostatic effect Effects 0.000 abstract description 6
230000029663 wound healing Effects 0.000 abstract description 5
230000001737 promoting effect Effects 0.000 abstract description 4
239000000463 material Substances 0.000 description 22
238000000576 coating method Methods 0.000 description 17
239000011248 coating agent Substances 0.000 description 16
239000000835 fiber Substances 0.000 description 15
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 12
229910052791 calcium Inorganic materials 0.000 description 12
239000011575 calcium Substances 0.000 description 8
239000000758 substrate Substances 0.000 description 7
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
-1 alkali metal alginate Chemical class 0.000 description 6
239000000499 gel Substances 0.000 description 6
229920000742 Cotton Polymers 0.000 description 5
239000010408 film Substances 0.000 description 5
239000000017 hydrogel Substances 0.000 description 5
239000007788 liquid Substances 0.000 description 5
239000004014 plasticizer Substances 0.000 description 5
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
239000002253 acid Substances 0.000 description 4
229920000728 polyester Polymers 0.000 description 4
150000003839 salts Chemical class 0.000 description 4
BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical group [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 3
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
229920000297 Rayon Polymers 0.000 description 3
239000000853 adhesive Substances 0.000 description 3
230000001070 adhesive effect Effects 0.000 description 3
230000008901 benefit Effects 0.000 description 3
239000008280 blood Substances 0.000 description 3
210000004369 blood Anatomy 0.000 description 3
239000003153 chemical reaction reagent Substances 0.000 description 3
235000019441 ethanol Nutrition 0.000 description 3
210000000416 exudates and transudate Anatomy 0.000 description 3
239000012530 fluid Substances 0.000 description 3
239000006260 foam Substances 0.000 description 3
229920000642 polymer Polymers 0.000 description 3
238000003756 stirring Methods 0.000 description 3
210000002268 wool Anatomy 0.000 description 3
SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 description 2
241001474374 Blennius Species 0.000 description 2
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
239000004820 Pressure-sensitive adhesive Substances 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
239000000654 additive Substances 0.000 description 2
WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 2
239000007900 aqueous suspension Substances 0.000 description 2
230000009286 beneficial effect Effects 0.000 description 2
229910001424 calcium ion Inorganic materials 0.000 description 2
125000002091 cationic group Chemical group 0.000 description 2
239000002131 composite material Substances 0.000 description 2
238000005520 cutting process Methods 0.000 description 2
239000003814 drug Substances 0.000 description 2
235000011187 glycerol Nutrition 0.000 description 2
230000035876 healing Effects 0.000 description 2
238000012986 modification Methods 0.000 description 2
230000004048 modification Effects 0.000 description 2
239000004033 plastic Substances 0.000 description 2
229920003023 plastic Polymers 0.000 description 2
239000002964 rayon Substances 0.000 description 2
229910001415 sodium ion Inorganic materials 0.000 description 2
239000000126 substance Substances 0.000 description 2
238000001356 surgical procedure Methods 0.000 description 2
229920003169 water-soluble polymer Polymers 0.000 description 2
GKFPPCXIBHQRQT-UHFFFAOYSA-N 6-(2-carboxy-4,5-dihydroxy-6-methoxyoxan-3-yl)oxy-4,5-dihydroxy-3-methoxyoxane-2-carboxylic acid Chemical compound OC1C(O)C(OC)OC(C(O)=O)C1OC1C(O)C(O)C(OC)C(C(O)=O)O1 GKFPPCXIBHQRQT-UHFFFAOYSA-N 0.000 description 1
208000035143 Bacterial infection Diseases 0.000 description 1
102000008186 Collagen Human genes 0.000 description 1
108010035532 Collagen Proteins 0.000 description 1
PHOQVHQSTUBQQK-SQOUGZDYSA-N D-glucono-1,5-lactone Chemical compound OC[C@H]1OC(=O)[C@H](O)[C@@H](O)[C@@H]1O PHOQVHQSTUBQQK-SQOUGZDYSA-N 0.000 description 1
102100038285 Endogenous retroviral envelope protein HEMO Human genes 0.000 description 1
229920002683 Glycosaminoglycan Polymers 0.000 description 1
101001033183 Homo sapiens Endogenous retroviral envelope protein HEMO Proteins 0.000 description 1
206010067482 No adverse event Diseases 0.000 description 1
239000004698 Polyethylene Substances 0.000 description 1
239000004743 Polypropylene Substances 0.000 description 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
239000005708 Sodium hypochlorite Substances 0.000 description 1
208000025865 Ulcer Diseases 0.000 description 1
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
239000002390 adhesive tape Substances 0.000 description 1
235000011037 adipic acid Nutrition 0.000 description 1
239000001361 adipic acid Substances 0.000 description 1
229960001126 alginic acid Drugs 0.000 description 1
239000000783 alginic acid Substances 0.000 description 1
150000004781 alginic acids Chemical class 0.000 description 1
229910052783 alkali metal Inorganic materials 0.000 description 1
235000010407 ammonium alginate Nutrition 0.000 description 1
229940035676 analgesics Drugs 0.000 description 1
239000000730 antalgic agent Substances 0.000 description 1
230000000844 anti-bacterial effect Effects 0.000 description 1
230000002421 anti-septic effect Effects 0.000 description 1
229940030225 antihemorrhagics Drugs 0.000 description 1
229940064004 antiseptic throat preparations Drugs 0.000 description 1
208000022362 bacterial infectious disease Diseases 0.000 description 1
239000003899 bactericide agent Substances 0.000 description 1
238000001266 bandaging Methods 0.000 description 1
230000033228 biological regulation Effects 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
239000007844 bleaching agent Substances 0.000 description 1
210000001124 body fluid Anatomy 0.000 description 1
239000010839 body fluid Substances 0.000 description 1
PBAYDYUZOSNJGU-UHFFFAOYSA-N chelidonic acid Natural products OC(=O)C1=CC(=O)C=C(C(O)=O)O1 PBAYDYUZOSNJGU-UHFFFAOYSA-N 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
230000003399 chemotactic effect Effects 0.000 description 1
230000035602 clotting Effects 0.000 description 1
229920001436 collagen Polymers 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
238000010276 construction Methods 0.000 description 1
230000032798 delamination Effects 0.000 description 1
238000009792 diffusion process Methods 0.000 description 1
238000007598 dipping method Methods 0.000 description 1
229940079593 drug Drugs 0.000 description 1
230000009977 dual effect Effects 0.000 description 1
210000002889 endothelial cell Anatomy 0.000 description 1
238000005516 engineering process Methods 0.000 description 1
239000002657 fibrous material Substances 0.000 description 1
238000011010 flushing procedure Methods 0.000 description 1
239000000417 fungicide Substances 0.000 description 1
239000007789 gas Substances 0.000 description 1
235000012209 glucono delta-lactone Nutrition 0.000 description 1
229960003681 gluconolactone Drugs 0.000 description 1
230000023597 hemostasis Effects 0.000 description 1
229940051250 hexylene glycol Drugs 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
238000005342 ion exchange Methods 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
238000002156 mixing Methods 0.000 description 1
NJTGANWAUPEOAX-UHFFFAOYSA-N molport-023-220-454 Chemical group OCC(O)CO.OCC(O)CO NJTGANWAUPEOAX-UHFFFAOYSA-N 0.000 description 1
235000019645 odor Nutrition 0.000 description 1
238000004806 packaging method and process Methods 0.000 description 1
239000002245 particle Substances 0.000 description 1
230000002093 peripheral effect Effects 0.000 description 1
230000035699 permeability Effects 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
229920000139 polyethylene terephthalate Polymers 0.000 description 1
239000005020 polyethylene terephthalate Substances 0.000 description 1
229920000098 polyolefin Polymers 0.000 description 1
229920001155 polypropylene Polymers 0.000 description 1
229920002635 polyurethane Polymers 0.000 description 1
239000004814 polyurethane Substances 0.000 description 1
229920006264 polyurethane film Polymers 0.000 description 1
230000002980 postoperative effect Effects 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000011591 potassium Substances 0.000 description 1
235000010408 potassium alginate Nutrition 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
239000003352 sequestering agent Substances 0.000 description 1
229910052709 silver Inorganic materials 0.000 description 1
239000004332 silver Substances 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
239000002904 solvent Substances 0.000 description 1
238000003892 spreading Methods 0.000 description 1
230000007480 spreading Effects 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
239000000725 suspension Substances 0.000 description 1
239000010409 thin film Substances 0.000 description 1
231100000397 ulcer Toxicity 0.000 description 1
239000004034 viscosity adjusting agent Substances 0.000 description 1
238000002166 wet spinning Methods 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1
239000011701 zinc Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/734—Alginic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Hematology (AREA)
Materials Engineering (AREA)
Bioinformatics & Cheminformatics (AREA)
Materials For Medical Uses (AREA)

CA002117257A 1994-04-06 1994-04-06 Pansement contenant de l'alginate Expired - Lifetime CA2117257C (fr)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
CA002117257A CA2117257C (fr)	1994-04-06	1994-04-06	Pansement contenant de l'alginate

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CA002117257A CA2117257C (fr)	1994-04-06	1994-04-06	Pansement contenant de l'alginate

Publications (2)

Publication Number	Publication Date
CA2117257A1 CA2117257A1 (fr)	1995-10-07
CA2117257C true CA2117257C (fr)	2005-12-27

Family

ID=4153052

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002117257A Expired - Lifetime CA2117257C (fr)	1994-04-06	1994-04-06	Pansement contenant de l'alginate

Country Status (1)

Country	Link
CA (1)	CA2117257C (fr)

1994
- 1994-04-06 CA CA002117257A patent/CA2117257C/fr not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CA2117257A1 (fr)	1995-10-07

Legal Events

Date	Code	Title	Description
2001-03-27	EEER	Examination request
2014-06-09	MKEX	Expiry	Effective date: 20140407

Publication	Publication Date	Title
US5470576A (en)	1995-11-28	Process for preparing the alginate-containing wound dressing
US12076448B2 (en)	2024-09-03	Hemostatic devices
US6552244B1 (en)	2003-04-22	Multi-layered wound dressing
US5836970A (en)	1998-11-17	Hemostatic wound dressing
EP0680344B1 (fr)	1998-04-01	Pansements pour blessures
CA1274733A (fr)	1990-10-02	Bandage adhesif hemostatique
US6033684A (en)	2000-03-07	Compositions and methods for wound management
CA1340750C (fr)	1999-09-14	Substance pour pansement hemostatique de plaie
US20060211972A1 (en)	2006-09-21	Wound dressing
JP2007521903A (ja)	2007-08-09	創傷用多層包帯
WO1994016746A1 (fr)	1994-08-04	Pansements pour blessures
EP1601388B1 (fr)	2011-04-27	Materiaux hydrocolloides destines a etre utilises dans la cicatrisation des blessures
CA2117257C (fr)	2005-12-27	Pansement contenant de l'alginate
US20240033398A1 (en)	2024-02-01	Hemostatic devices
HK1230110A1 (en)	2017-12-01	Clay-based hemostatic agents and devices for the delivery thereof