CA2128190A1 - Methode d'identification de tissus - Google Patents
Methode d'identification de tissusInfo
- Publication number
- CA2128190A1 CA2128190A1 CA 2128190 CA2128190A CA2128190A1 CA 2128190 A1 CA2128190 A1 CA 2128190A1 CA 2128190 CA2128190 CA 2128190 CA 2128190 A CA2128190 A CA 2128190A CA 2128190 A1 CA2128190 A1 CA 2128190A1
- Authority
- CA
- Canada
- Prior art keywords
- tissue
- infrared
- malignant
- normal
- tissues
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000000034 method Methods 0.000 title claims abstract description 24
- 238000002329 infrared spectrum Methods 0.000 claims abstract description 100
- 210000001519 tissue Anatomy 0.000 claims description 183
- 210000000981 epithelium Anatomy 0.000 claims description 105
- 230000003211 malignant effect Effects 0.000 claims description 104
- 210000002808 connective tissue Anatomy 0.000 claims description 91
- 210000001072 colon Anatomy 0.000 claims description 35
- 238000005033 Fourier transform infrared spectroscopy Methods 0.000 claims description 9
- 230000015654 memory Effects 0.000 claims description 9
- 210000004400 mucous membrane Anatomy 0.000 claims description 7
- 238000001228 spectrum Methods 0.000 description 68
- 210000004027 cell Anatomy 0.000 description 49
- 102000004169 proteins and genes Human genes 0.000 description 39
- 108090000623 proteins and genes Proteins 0.000 description 39
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 29
- 150000001408 amides Chemical class 0.000 description 24
- 210000004877 mucosa Anatomy 0.000 description 23
- 102000039446 nucleic acids Human genes 0.000 description 21
- 108020004707 nucleic acids Proteins 0.000 description 21
- 150000007523 nucleic acids Chemical class 0.000 description 21
- 230000007423 decrease Effects 0.000 description 18
- 150000002632 lipids Chemical class 0.000 description 18
- 210000003679 cervix uteri Anatomy 0.000 description 17
- 150000004713 phosphodiesters Chemical group 0.000 description 17
- 102000008186 Collagen Human genes 0.000 description 14
- 108010035532 Collagen Proteins 0.000 description 14
- 229910019142 PO4 Inorganic materials 0.000 description 13
- 239000010452 phosphate Substances 0.000 description 13
- 201000011510 cancer Diseases 0.000 description 12
- 239000001257 hydrogen Substances 0.000 description 12
- 229910052739 hydrogen Inorganic materials 0.000 description 12
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 12
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 11
- 206010028980 Neoplasm Diseases 0.000 description 10
- 230000000112 colonic effect Effects 0.000 description 10
- 229920002527 Glycogen Polymers 0.000 description 9
- 238000004566 IR spectroscopy Methods 0.000 description 9
- 230000001413 cellular effect Effects 0.000 description 9
- 229940096919 glycogen Drugs 0.000 description 9
- 239000000835 fiber Substances 0.000 description 8
- 210000004379 membrane Anatomy 0.000 description 8
- 239000012528 membrane Substances 0.000 description 8
- 210000004953 colonic tissue Anatomy 0.000 description 7
- 206010008342 Cervix carcinoma Diseases 0.000 description 6
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 6
- 238000005452 bending Methods 0.000 description 6
- 201000010881 cervical cancer Diseases 0.000 description 6
- 229920001436 collagen Polymers 0.000 description 6
- 210000000056 organ Anatomy 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 229910014033 C-OH Inorganic materials 0.000 description 5
- 102000012422 Collagen Type I Human genes 0.000 description 5
- 108010022452 Collagen Type I Proteins 0.000 description 5
- 206010009944 Colon cancer Diseases 0.000 description 5
- 229910014570 C—OH Inorganic materials 0.000 description 5
- 150000001720 carbohydrates Chemical class 0.000 description 5
- 235000014633 carbohydrates Nutrition 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 208000035475 disorder Diseases 0.000 description 5
- 230000009878 intermolecular interaction Effects 0.000 description 5
- 238000012856 packing Methods 0.000 description 5
- 125000003368 amide group Chemical group 0.000 description 4
- 238000001574 biopsy Methods 0.000 description 4
- 231100000504 carcinogenesis Toxicity 0.000 description 4
- 208000029742 colonic neoplasm Diseases 0.000 description 4
- 230000000762 glandular Effects 0.000 description 4
- 230000003993 interaction Effects 0.000 description 4
- 230000036210 malignancy Effects 0.000 description 4
- 230000026731 phosphorylation Effects 0.000 description 4
- 238000006366 phosphorylation reaction Methods 0.000 description 4
- 239000010453 quartz Substances 0.000 description 4
- 238000002271 resection Methods 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 208000005623 Carcinogenesis Diseases 0.000 description 3
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 3
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 3
- 206010064912 Malignant transformation Diseases 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 230000002776 aggregation Effects 0.000 description 3
- 238000004220 aggregation Methods 0.000 description 3
- 230000036952 cancer formation Effects 0.000 description 3
- 210000002744 extracellular matrix Anatomy 0.000 description 3
- 102000034238 globular proteins Human genes 0.000 description 3
- 108091005896 globular proteins Proteins 0.000 description 3
- 230000033001 locomotion Effects 0.000 description 3
- 230000036212 malign transformation Effects 0.000 description 3
- 230000003595 spectral effect Effects 0.000 description 3
- QEMSVZNTSXPFJA-HNAYVOBHSA-N 1-[(1s,2s)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]-4-phenylpiperidin-4-ol Chemical compound C1([C@H](O)[C@H](C)N2CCC(O)(CC2)C=2C=CC=CC=2)=CC=C(O)C=C1 QEMSVZNTSXPFJA-HNAYVOBHSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 102000000503 Collagen Type II Human genes 0.000 description 2
- 108010041390 Collagen Type II Proteins 0.000 description 2
- 229910000661 Mercury cadmium telluride Inorganic materials 0.000 description 2
- 108010081750 Reticulin Proteins 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000001680 brushing effect Effects 0.000 description 2
- MCMSPRNYOJJPIZ-UHFFFAOYSA-N cadmium;mercury;tellurium Chemical compound [Cd]=[Te]=[Hg] MCMSPRNYOJJPIZ-UHFFFAOYSA-N 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 210000001608 connective tissue cell Anatomy 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 239000010432 diamond Substances 0.000 description 2
- 229910003460 diamond Inorganic materials 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 210000005081 epithelial layer Anatomy 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 125000000524 functional group Chemical group 0.000 description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 230000037361 pathway Effects 0.000 description 2
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 238000007790 scraping Methods 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000007704 transition Effects 0.000 description 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 description 1
- 206010058314 Dysplasia Diseases 0.000 description 1
- 102000016942 Elastin Human genes 0.000 description 1
- 108010014258 Elastin Proteins 0.000 description 1
- 102000006947 Histones Human genes 0.000 description 1
- 108010033040 Histones Proteins 0.000 description 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- 208000035346 Margins of Excision Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 208000006994 Precancerous Conditions Diseases 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
- 239000004473 Threonine Substances 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 238000002306 biochemical method Methods 0.000 description 1
- 238000005460 biophysical method Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000006664 bond formation reaction Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 210000004177 elastic tissue Anatomy 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 238000009499 grossing Methods 0.000 description 1
- 230000002706 hydrostatic effect Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 210000005228 liver tissue Anatomy 0.000 description 1
- 208000029565 malignant colon neoplasm Diseases 0.000 description 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000003387 muscular Effects 0.000 description 1
- 230000010309 neoplastic transformation Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 230000004845 protein aggregation Effects 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/28—Investigating the spectrum
- G01J3/42—Absorption spectrometry; Double beam spectrometry; Flicker spectrometry; Reflection spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
Landscapes
- Physics & Mathematics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- General Physics & Mathematics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA 2128190 CA2128190A1 (fr) | 1994-07-15 | 1994-07-15 | Methode d'identification de tissus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA 2128190 CA2128190A1 (fr) | 1994-07-15 | 1994-07-15 | Methode d'identification de tissus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2128190A1 true CA2128190A1 (fr) | 1996-01-16 |
Family
ID=4154015
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2128190 Abandoned CA2128190A1 (fr) | 1994-07-15 | 1994-07-15 | Methode d'identification de tissus |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2128190A1 (fr) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2133023A1 (fr) * | 2008-06-11 | 2009-12-16 | Sumitomo Electric Industries, Ltd. | Dispositif et procédé de discrimination de tissu vital |
| CN107655847A (zh) * | 2017-11-17 | 2018-02-02 | 黑龙江八农垦大学 | 针对难分辨中草药的利用红外光谱进行可视化表达的方法 |
-
1994
- 1994-07-15 CA CA 2128190 patent/CA2128190A1/fr not_active Abandoned
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2133023A1 (fr) * | 2008-06-11 | 2009-12-16 | Sumitomo Electric Industries, Ltd. | Dispositif et procédé de discrimination de tissu vital |
| CN107655847A (zh) * | 2017-11-17 | 2018-02-02 | 黑龙江八农垦大学 | 针对难分辨中草药的利用红外光谱进行可视化表达的方法 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5539207A (en) | Method of identifying tissue | |
| Wong et al. | Pressure-tuning FT-IR study of human cervical tissues | |
| Ci et al. | Fourier transform infrared spectroscopic characterization of human breast tissue: implications for breast cancer diagnosis | |
| US6954667B2 (en) | Method for Raman chemical imaging and characterization of calcification in tissue | |
| CA2008831C (fr) | Methode de spectroscopie a infrarouge pour la detection de la presence d'anomalies dans les tissus biologiques et les cellules sous forme naturelle ou cultivees | |
| Mahadevan-Jansen et al. | Raman spectroscopy for the detection of cancers and precancers | |
| Simonova et al. | Application of Fourier transform infrared spectroscopy for tumor diagnosis | |
| Krafft et al. | Near infrared Raman spectroscopic mapping of native brain tissue and intracranial tumors | |
| Maziak et al. | Fourier-transform infrared spectroscopic study of characteristic molecular structure in cancer cells of esophagus: an exploratory study | |
| Andrus et al. | Cancer grading by Fourier transform infrared spectroscopy | |
| Choo et al. | In situ characterization of beta-amyloid in Alzheimer's diseased tissue by synchrotron Fourier transform infrared microspectroscopy | |
| Wong et al. | Infrared spectra of microtome sections of human colon tissues | |
| US5891619A (en) | System and method for mapping the distribution of normal and abnormal cells in sections of tissue | |
| Krafft et al. | Analysis of human brain tissue, brain tumors and tumor cells by infrared spectroscopic mapping | |
| Conti et al. | FT-IR microimaging spectroscopy: A comparison between healthy and neoplastic human colon tissues | |
| Steiner et al. | Distinguishing and grading human gliomas by IR spectroscopy | |
| Wang et al. | FT-IR spectroscopic analysis of normal and cancerous tissues of esophagus | |
| EP2577298B1 (fr) | Diagnostic du cancer | |
| Camerlingo et al. | Wavelet data processing of micro-Raman spectra of biological samples | |
| US20050250091A1 (en) | Raman molecular imaging for detection of bladder cancer | |
| Petter et al. | Development and application of Fourier-transform infrared chemical imaging of tumour in human tissue | |
| Guo et al. | Precise diagnosis of lung cancer enabled by improved FTIR-based machine learning | |
| Jackson et al. | Cancer diagnosis by infrared spectroscopy: methodological aspects | |
| Ramesh et al. | FTIR microscopic studies on normal, polyp, and malignant human colonic tissues | |
| Mehrotra et al. | Infrared spectroscopic analysis of tumor pathology |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Dead |