CA2131355C - Production d'une immunoglobuline codee par un gene unique - Google Patents

Production d'une immunoglobuline codee par un gene unique Download PDF

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Publication number
CA2131355C
CA2131355C CA 2131355 CA2131355A CA2131355C CA 2131355 C CA2131355 C CA 2131355C CA 2131355 CA2131355 CA 2131355 CA 2131355 A CA2131355 A CA 2131355A CA 2131355 C CA2131355 C CA 2131355C
Authority
CA
Canada
Prior art keywords
polypeptide
variable region
chain variable
immunoglobulin
heavy chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA 2131355
Other languages
English (en)
Other versions
CA2131355A1 (fr
Inventor
Syed V. S. Kashmiri
Liming Shu
Jeffrey Schlom
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Government of the United States of America
Original Assignee
Government of the United States of America
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Government of the United States of America filed Critical Government of the United States of America
Priority to CA 2131355 priority Critical patent/CA2131355C/fr
Publication of CA2131355A1 publication Critical patent/CA2131355A1/fr
Application granted granted Critical
Publication of CA2131355C publication Critical patent/CA2131355C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
CA 2131355 1994-09-01 1994-09-01 Production d'une immunoglobuline codee par un gene unique Expired - Lifetime CA2131355C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA 2131355 CA2131355C (fr) 1994-09-01 1994-09-01 Production d'une immunoglobuline codee par un gene unique

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA 2131355 CA2131355C (fr) 1994-09-01 1994-09-01 Production d'une immunoglobuline codee par un gene unique

Publications (2)

Publication Number Publication Date
CA2131355A1 CA2131355A1 (fr) 1996-03-02
CA2131355C true CA2131355C (fr) 2001-04-17

Family

ID=4154274

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2131355 Expired - Lifetime CA2131355C (fr) 1994-09-01 1994-09-01 Production d'une immunoglobuline codee par un gene unique

Country Status (1)

Country Link
CA (1) CA2131355C (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6818749B1 (en) 1998-10-31 2004-11-16 The United States Of America As Represented By The Department Of Health And Human Services Variants of humanized anti carcinoma monoclonal antibody cc49
CA2490659C (fr) 2002-06-28 2014-08-19 Syed V. S. Kashmiri Les cc49, anti-tag-72 humanises servant au diagnostic et au traitement de tumeurs chez l'homme
WO2005021594A2 (fr) 2003-08-29 2005-03-10 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Variants a peine immunogenes de l'anticorps humanise a greffe sdr cc49 et leur utilisation

Also Published As

Publication number Publication date
CA2131355A1 (fr) 1996-03-02

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Effective date: 20140902