CA2136241C - Indoles a base de quinoleines fluores en tant qu'inhibiteurs de la biosynthese de leucotrienes - Google Patents

Indoles a base de quinoleines fluores en tant qu'inhibiteurs de la biosynthese de leucotrienes Download PDF

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Publication number
CA2136241C
CA2136241C CA002136241A CA2136241A CA2136241C CA 2136241 C CA2136241 C CA 2136241C CA 002136241 A CA002136241 A CA 002136241A CA 2136241 A CA2136241 A CA 2136241A CA 2136241 C CA2136241 C CA 2136241C
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CA
Canada
Prior art keywords
compound
formula
pharmaceutically acceptable
medicament
effective amount
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002136241A
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English (en)
Other versions
CA2136241A1 (fr
Inventor
Richard Frenette
John Hutchinson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Canada Inc
Original Assignee
Merck Frosst Canada and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/903,051 external-priority patent/US5252585A/en
Application filed by Merck Frosst Canada and Co filed Critical Merck Frosst Canada and Co
Publication of CA2136241A1 publication Critical patent/CA2136241A1/fr
Application granted granted Critical
Publication of CA2136241C publication Critical patent/CA2136241C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002136241A 1992-06-22 1993-06-17 Indoles a base de quinoleines fluores en tant qu'inhibiteurs de la biosynthese de leucotrienes Expired - Fee Related CA2136241C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US903,051 1992-06-22
US07/903,051 US5252585A (en) 1992-02-03 1992-06-22 Fluorinated quinoline indoles as inhibitors of the biosynthesis of leukotrienes
PCT/CA1993/000256 WO1994000446A1 (fr) 1992-06-22 1993-06-17 Quinoleine indoles fluores utilises comme inhibiteurs de la biosynthese de leucotrienes

Publications (2)

Publication Number Publication Date
CA2136241A1 CA2136241A1 (fr) 1994-01-06
CA2136241C true CA2136241C (fr) 2004-01-27

Family

ID=25416859

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002136241A Expired - Fee Related CA2136241C (fr) 1992-06-22 1993-06-17 Indoles a base de quinoleines fluores en tant qu'inhibiteurs de la biosynthese de leucotrienes

Country Status (3)

Country Link
AU (1) AU4413893A (fr)
CA (1) CA2136241C (fr)
WO (1) WO1994000446A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2431927B (en) 2005-11-04 2010-03-17 Amira Pharmaceuticals Inc 5-Lipoxygenase-activating protein (FLAP) inhibitors
US8399666B2 (en) 2005-11-04 2013-03-19 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
US7977359B2 (en) 2005-11-04 2011-07-12 Amira Pharmaceuticals, Inc. 5-lipdxygenase-activating protein (FLAP) inhibitors
WO2008097930A1 (fr) * 2007-02-05 2008-08-14 Amira Pharmaceuticals, Inc. Indoles inverses en tant qu'inhibiteurs de la protéine d'activation de la 5-lipoxygénase (flap)
WO2008103866A1 (fr) * 2007-02-22 2008-08-28 Microbia, Inc. Synthèse d'indoles
MX2010012814A (es) 2008-05-23 2010-12-20 Amira Pharmaceuticals Inc Inhibidor de proteina activadora de 5-lipoxigenasa.
US8546431B2 (en) 2008-10-01 2013-10-01 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE59889B1 (en) * 1986-02-14 1994-04-20 Merck Frosst Canada Inc 2-substituted quinoline dioic acids
NZ234883A (en) * 1989-08-22 1995-01-27 Merck Frosst Canada Inc Quinolin-2-ylmethoxy indole derivatives, preparation and pharmaceutical compositions thereof
US5095031A (en) * 1990-08-20 1992-03-10 Abbott Laboratories Indole derivatives which inhibit leukotriene biosynthesis

Also Published As

Publication number Publication date
WO1994000446A1 (fr) 1994-01-06
CA2136241A1 (fr) 1994-01-06
AU4413893A (en) 1994-01-24

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