CA2138765C - Proteine d'haemophilus influenzae de recombinaison et sequence nucleotide les codant - Google Patents

Proteine d'haemophilus influenzae de recombinaison et sequence nucleotide les codant

Info

Publication number: CA2138765C
Authority: CA; Canada
Prior art keywords: protein; dna; influenzae; sequence; adhesin
Prior art date: 1992-06-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

CA002138765A

Other languages

English (en)

Other versions

CA2138765A1 (fr

Inventor

Howard C. Krivan

James E. Samuel

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Emergent Product Development Gaithersburg Inc

Original Assignee

Antex Biologics Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-06-22

Filing date

1993-06-22

Publication date

1999-09-07

1992-06-22 Priority claimed from US07/903,079 external-priority patent/US5843463A/en

1993-06-22 Application filed by Antex Biologics Inc filed Critical Antex Biologics Inc

1994-01-06 Publication of CA2138765A1 publication Critical patent/CA2138765A1/fr

1999-09-07 Application granted granted Critical

1999-09-07 Publication of CA2138765C publication Critical patent/CA2138765C/fr

2013-06-22 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

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238000002741 site-directed mutagenesis Methods 0.000 description 1
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239000001488 sodium phosphate Substances 0.000 description 1
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235000019345 sodium thiosulphate Nutrition 0.000 description 1
230000003381 solubilizing effect Effects 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
238000002798 spectrophotometry method Methods 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
210000000952 spleen Anatomy 0.000 description 1
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239000008107 starch Substances 0.000 description 1
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239000012258 stirred mixture Substances 0.000 description 1
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239000007929 subcutaneous injection Substances 0.000 description 1
238000010254 subcutaneous injection Methods 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
238000012360 testing method Methods 0.000 description 1
DLYUQMMRRRQYAE-UHFFFAOYSA-N tetraphosphorus decaoxide Chemical compound O1P(O2)(=O)OP3(=O)OP1(=O)OP2(=O)O3 DLYUQMMRRRQYAE-UHFFFAOYSA-N 0.000 description 1
108010061238 threonyl-glycine Proteins 0.000 description 1
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239000003053 toxin Substances 0.000 description 1
231100000765 toxin Toxicity 0.000 description 1
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230000002103 transcriptional effect Effects 0.000 description 1
238000005809 transesterification reaction Methods 0.000 description 1
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125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
238000005866 tritylation reaction Methods 0.000 description 1
239000012588 trypsin Substances 0.000 description 1
241001515965 unidentified phage Species 0.000 description 1
108010073969 valyllysine Proteins 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
239000013603 viral vector Substances 0.000 description 1
230000001018 virulence Effects 0.000 description 1
238000005406 washing Methods 0.000 description 1

Landscapes

Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Saccharide Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

CA002138765A 1992-06-22 1993-06-22 Proteine d'haemophilus influenzae de recombinaison et sequence nucleotide les codant Expired - Fee Related CA2138765C (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US07/903,079 US5843463A (en)	1990-12-21	1992-06-22	Adhesin-oligosaccharide conjugate vaccine for Haemophilus influenzae
US07/903,079		1992-06-22
PCT/US1993/006016 WO1994000149A1 (fr)	1990-12-21	1993-06-22	VACCIN CONJUGUE ADHESINE-OLIGOSACCHARIDE CONTRE $i(HAEMOPHILUS INFLUENZAE)

Publications (2)

Publication Number	Publication Date
CA2138765A1 CA2138765A1 (fr)	1994-01-06
CA2138765C true CA2138765C (fr)	1999-09-07

Family

ID=25416904

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002138765A Expired - Fee Related CA2138765C (fr)	1992-06-22	1993-06-22	Proteine d'haemophilus influenzae de recombinaison et sequence nucleotide les codant

Country Status (3)

Country	Link
EP (1)	EP0647139A4 (fr)
JP (1)	JP2805174B2 (fr)
CA (1)	CA2138765C (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4856836B2 (ja) *	2000-03-01	2012-01-18	バイナックスインコーポレイティッド	標的細菌またはその標的糖質抗原成分の存在を検出する方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE68915046T2 (de) *	1988-04-19	1994-12-08	American Cyanamid Co	Haemophilus influenzae Typ B Polysaccharid-Aussermembranprotein-Konjugat als Impfstoff.
ES2131066T3 (es) *	1990-12-21	1999-07-16	Antex Biolog Inc	Vacuna de conjugacion de oligosacarido con adhesina para hi(haemophilus influenzae).

1993
- 1993-06-22 EP EP93916717A patent/EP0647139A4/fr not_active Withdrawn
- 1993-06-22 JP JP6502559A patent/JP2805174B2/ja not_active Expired - Fee Related
- 1993-06-22 CA CA002138765A patent/CA2138765C/fr not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0647139A4 (fr)	1997-09-03
JPH07509693A (ja)	1995-10-26
JP2805174B2 (ja)	1998-09-30
CA2138765A1 (fr)	1994-01-06
EP0647139A1 (fr)	1995-04-12

Legal Events

Date	Code	Title	Description
1994-12-21	EEER	Examination request
1999-01-15	FZDC	Discontinued application reinstated
2009-06-22	MKLA	Lapsed
2023-05-26	MKLA	Lapsed	Effective date: 20090622

Publication	Publication Date	Title
US5679547A (en)	1997-10-21	Method for producing a novel purified Haemophilus influenzae protein
KR100927767B1 (ko)	2009-11-20	스트렙토코커스 항원
US5679352A (en)	1997-10-21	Synthetic Haemophilus influenzae conjugate vaccine
KR100771148B1 (ko)	2007-10-29	그룹 ｂ 스트렙토코커스 항원
JP4767540B2 (ja)	2011-09-07	髄膜炎菌タンパク質ｎｍｂ１８７０の複数の改変体
US20060251675A1 (en)	2006-11-09	Mutant cholera holotoxin as an adjuvant and an antigen carrier protein
JP2006521782A5 (fr)	2006-11-24
EP0565590B1 (fr)	1999-03-03	VACCIN CONJUGUE ADHESINE-OLIGOSACCHARIDE CONTRE $i(HAEMOPHILUS INFLUENZAE)
CA2347849A1 (fr)	2000-04-27	Proteines omp85 de neisseria gonorrhoeae et de neisseria meningitidis, compositions renfermant lesdites proteines et methodes d'utilisation correspondantes
US8003112B2 (en)	2011-08-23	Meningococcal and pneumococcal conjugate vaccine and method of using same
CA2138765C (fr)	1999-09-07	Proteine d'haemophilus influenzae de recombinaison et sequence nucleotide les codant
EP1313771B1 (fr)	2007-03-21	Epitopes d'oligosaccharide a noyau interne de lipopolysaccharide d' i haemophilus /i i influenzae /i utilises comme vaccins pour prevenir les infections a i haemophilus influenzae /i
AU750792B2 (en)	2002-07-25	76 kDa, 32 kDa, and 50 kDa helicobacter polypeptides and corresponding polynucleotide molecules
CA2182046A1 (fr)	1998-01-26	Adhesine, proteine de surface d'haemophilus
EP1535928B1 (fr)	2008-07-16	Vaccin comprenant Omp85 protéines de Neisseria gonorhoeae et Neisseria meningitidis
HK1122048A (en)	2009-05-08	Streptococcus antigens