CA2144319A1 - Polypeptides ctla4 recombinants et methodes d'obtention - Google Patents
Polypeptides ctla4 recombinants et methodes d'obtentionInfo
- Publication number
- CA2144319A1 CA2144319A1 CA002144319A CA2144319A CA2144319A1 CA 2144319 A1 CA2144319 A1 CA 2144319A1 CA 002144319 A CA002144319 A CA 002144319A CA 2144319 A CA2144319 A CA 2144319A CA 2144319 A1 CA2144319 A1 CA 2144319A1
- Authority
- CA
- Canada
- Prior art keywords
- ctla4
- polypeptide
- active
- protein
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La présente invention porte sur des polypeptides CTLA4 produits par recombinaison et conservant une activité de liaison B7, sans pour autant résulter de la fusion entre le CTLA4 et les gènes Ig humains. Les polypeptides CTLA4 de la présente invention comportent généralement une séquence d'acide aminé correspondant au domaine extra-cellulaire de la protéine réceptrice du CTLA4. En outre, l'invention concerne des dérivés fonctionnels des polypeptides CTLA4, y compris des mutéines et des conjugués contenant du polyéthylène glycol. L'invention porte également sur la préparation des polypeptides CTLA4 recombinants et sur les procédés de séparation des formes monomères et dimères des polypeptides recombinants ainsi que les formes des dimères actives et moins actives.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9053393A | 1993-07-09 | 1993-07-09 | |
| US08/090,533 | 1993-07-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2144319A1 true CA2144319A1 (fr) | 1995-01-19 |
Family
ID=22223206
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002144319A Abandoned CA2144319A1 (fr) | 1993-07-09 | 1994-07-08 | Polypeptides ctla4 recombinants et methodes d'obtention |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0665852A1 (fr) |
| JP (1) | JPH08506247A (fr) |
| AU (1) | AU7326594A (fr) |
| CA (1) | CA2144319A1 (fr) |
| WO (1) | WO1995001994A1 (fr) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5855887A (en) * | 1995-07-25 | 1999-01-05 | The Regents Of The University Of California | Blockade of lymphocyte down-regulation associated with CTLA-4 signaling |
| US6051227A (en) * | 1995-07-25 | 2000-04-18 | The Regents Of The University Of California, Office Of Technology Transfer | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
| US5811097A (en) * | 1995-07-25 | 1998-09-22 | The Regents Of The University Of California | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
| US6750334B1 (en) * | 1996-02-02 | 2004-06-15 | Repligen Corporation | CTLA4-immunoglobulin fusion proteins having modified effector functions and uses therefor |
| AUPP221098A0 (en) | 1998-03-06 | 1998-04-02 | Diatech Pty Ltd | V-like domain binding molecules |
| EP0947582A1 (fr) * | 1998-03-31 | 1999-10-06 | Innogenetics N.V. | Une structure polypeptidique utilisable comme un squelette |
| US7109003B2 (en) | 1998-12-23 | 2006-09-19 | Abgenix, Inc. | Methods for expressing and recovering human monoclonal antibodies to CTLA-4 |
| CZ302706B6 (cs) | 1998-12-23 | 2011-09-14 | Pfizer Inc. | Lidská monoklonální protilátka, farmaceutická kompozice tuto protilátku obsahující, bunecná linie produkující tuto protilátku, izolovaná molekula kódující težký nebo lehký retezec uvedené protilátky, hostitelská bunka obsahující tuto izolovanou molek |
| US6682736B1 (en) | 1998-12-23 | 2004-01-27 | Abgenix, Inc. | Human monoclonal antibodies to CTLA-4 |
| EP1212422B1 (fr) | 1999-08-24 | 2007-02-21 | Medarex, Inc. | Anticorps contre l'antigene ctla-4 humain et utilisation |
| US7605238B2 (en) | 1999-08-24 | 2009-10-20 | Medarex, Inc. | Human CTLA-4 antibodies and their uses |
| US7094874B2 (en) | 2000-05-26 | 2006-08-22 | Bristol-Myers Squibb Co. | Soluble CTLA4 mutant molecules |
| NZ536420A (en) | 2002-04-12 | 2008-04-30 | Medarex Inc | Methods of treatment using CTLA-4 antibodies |
| EP1597273A2 (fr) | 2003-02-27 | 2005-11-23 | TheraVision GmbH | Ctla4 polypeptides solubles et procedes de fabrication associes |
| US8110194B2 (en) | 2005-12-07 | 2012-02-07 | Medarex, Inc. | CTLA-4 antibody dosage escalation regimens |
| US8216996B2 (en) | 2006-03-03 | 2012-07-10 | Ono Pharmaceutical Co., Ltd. | Multimer of extracellular domain of cell surface functional molecule |
| GB0620934D0 (en) * | 2006-10-20 | 2006-11-29 | Cambridge Antibody Tech | Protein variants |
| CA2696699A1 (fr) | 2007-08-20 | 2009-02-26 | Protalix Ltd. | Conjugues de proteines contenant un saccharide et leurs utilisations |
| NO2344540T3 (fr) | 2008-10-02 | 2018-04-28 | ||
| US9194011B2 (en) | 2009-11-17 | 2015-11-24 | Protalix Ltd. | Stabilized alpha-galactosidase and uses thereof |
| US20130017169A1 (en) * | 2010-03-02 | 2013-01-17 | Protalix Ltd. | Multimeric forms of therapeutic proteins and uses thereof |
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Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5770197A (en) * | 1991-06-27 | 1998-06-23 | Bristol-Myers Squibb Company | Methods for regulating the immune response using B7 binding molecules and IL4-binding molecules |
| CA2580812A1 (fr) * | 1991-06-27 | 1993-01-07 | Bristol-Myers Squibb Company | Recepteur ctla, proteines hybrides qui le contiennent et ses applications |
-
1994
- 1994-07-08 EP EP94923387A patent/EP0665852A1/fr not_active Withdrawn
- 1994-07-08 CA CA002144319A patent/CA2144319A1/fr not_active Abandoned
- 1994-07-08 AU AU73265/94A patent/AU7326594A/en not_active Abandoned
- 1994-07-08 WO PCT/US1994/007685 patent/WO1995001994A1/fr not_active Ceased
- 1994-07-08 JP JP7504186A patent/JPH08506247A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP0665852A1 (fr) | 1995-08-09 |
| WO1995001994A1 (fr) | 1995-01-19 |
| AU7326594A (en) | 1995-02-06 |
| JPH08506247A (ja) | 1996-07-09 |
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