CA2154860A1 - Produits pour soins buccaux, a base de complexe de zinc-polyamine et de pyrophosphate - Google Patents

Produits pour soins buccaux, a base de complexe de zinc-polyamine et de pyrophosphate

Info

Publication number: CA2154860A1
Authority: CA; Canada
Prior art keywords: zinc; oral care; care product; accordance; ingredient
Prior art date: 1994-07-26
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA 2154860

Other languages

English (en)

Inventor

Todd W. Domke

Wolfgang R. Bergmann

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Church and Dwight Co Inc

Original Assignee

Church and Dwight Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-07-26

Filing date

1995-07-24

Publication date

1996-01-27

1995-07-24 Application filed by Church and Dwight Co Inc filed Critical Church and Dwight Co Inc

1996-01-27 Publication of CA2154860A1 publication Critical patent/CA2154860A1/fr

Status Abandoned legal-status Critical Current

Links

229920000768 polyamine Polymers 0.000 title claims abstract description 42
235000011180 diphosphates Nutrition 0.000 title claims abstract description 9
XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 title description 5
XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims abstract description 80
239000011787 zinc oxide Substances 0.000 claims abstract description 39
150000003752 zinc compounds Chemical class 0.000 claims abstract description 36
229920002873 Polyethylenimine Polymers 0.000 claims abstract description 33
210000000214 mouth Anatomy 0.000 claims abstract description 11
-1 alkali metal pyrophosphate Chemical class 0.000 claims abstract description 10
WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 claims abstract description 10
229940068475 zinc citrate Drugs 0.000 claims abstract description 10
239000011746 zinc citrate Substances 0.000 claims abstract description 10
235000006076 zinc citrate Nutrition 0.000 claims abstract description 10
229910052783 alkali metal Inorganic materials 0.000 claims abstract description 5
239000004615 ingredient Substances 0.000 claims description 42
239000000203 mixture Substances 0.000 claims description 28
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 24
238000009472 formulation Methods 0.000 claims description 18
239000000606 toothpaste Substances 0.000 claims description 12
229940034610 toothpaste Drugs 0.000 claims description 10
230000002272 anti-calculus Effects 0.000 claims description 9
238000000034 method Methods 0.000 claims description 8
239000002324 mouth wash Substances 0.000 claims description 7
229940051866 mouthwash Drugs 0.000 claims description 5
239000002245 particle Substances 0.000 claims description 5
239000004094 surface-active agent Substances 0.000 claims description 5
230000015572 biosynthetic process Effects 0.000 claims description 3
208000006558 Dental Calculus Diseases 0.000 claims description 2
FMRLDPWIRHBCCC-UHFFFAOYSA-L Zinc carbonate Chemical group [Zn+2].[O-]C([O-])=O FMRLDPWIRHBCCC-UHFFFAOYSA-L 0.000 claims description 2
239000004110 Zinc silicate Substances 0.000 claims description 2
239000011667 zinc carbonate Substances 0.000 claims description 2
235000004416 zinc carbonate Nutrition 0.000 claims description 2
229910000010 zinc carbonate Inorganic materials 0.000 claims description 2
XSMMCTCMFDWXIX-UHFFFAOYSA-N zinc silicate Chemical group [Zn+2].[O-][Si]([O-])=O XSMMCTCMFDWXIX-UHFFFAOYSA-N 0.000 claims description 2
235000019352 zinc silicate Nutrition 0.000 claims description 2
XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical group [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 claims description 2
JDLYKQWJXAQNNS-UHFFFAOYSA-L zinc;dibenzoate Chemical group [Zn+2].[O-]C(=O)C1=CC=CC=C1.[O-]C(=O)C1=CC=CC=C1 JDLYKQWJXAQNNS-UHFFFAOYSA-L 0.000 claims description 2
ZPEJZWGMHAKWNL-UHFFFAOYSA-L zinc;oxalate Chemical group [Zn+2].[O-]C(=O)C([O-])=O ZPEJZWGMHAKWNL-UHFFFAOYSA-L 0.000 claims description 2
206010044029 Tooth deposit Diseases 0.000 claims 1
125000000129 anionic group Chemical group 0.000 claims 1
239000003945 anionic surfactant Substances 0.000 claims 1
125000002091 cationic group Chemical group 0.000 claims 1
239000003093 cationic surfactant Substances 0.000 claims 1
239000000001 dental powder Substances 0.000 claims 1
239000002736 nonionic surfactant Substances 0.000 claims 1
PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 abstract description 14
208000007565 gingivitis Diseases 0.000 abstract description 4
239000011701 zinc Substances 0.000 description 39
235000014692 zinc oxide Nutrition 0.000 description 37
239000000047 product Substances 0.000 description 36
229910052725 zinc Inorganic materials 0.000 description 30
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 29
239000000551 dentifrice Substances 0.000 description 28
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 20
239000007864 aqueous solution Substances 0.000 description 20
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 18
FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 15
239000000243 solution Substances 0.000 description 15
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 14
PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 14
235000019818 tetrasodium diphosphate Nutrition 0.000 description 13
239000012153 distilled water Substances 0.000 description 12
VSJRDSLPNMGNFG-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate;trihydrate Chemical compound O.O.O.[Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O VSJRDSLPNMGNFG-UHFFFAOYSA-H 0.000 description 11
229940085658 zinc citrate trihydrate Drugs 0.000 description 11
239000000796 flavoring agent Substances 0.000 description 10
235000019634 flavors Nutrition 0.000 description 10
235000011187 glycerol Nutrition 0.000 description 10
238000003756 stirring Methods 0.000 description 10
235000017557 sodium bicarbonate Nutrition 0.000 description 9
229910000030 sodium bicarbonate Inorganic materials 0.000 description 9
238000012360 testing method Methods 0.000 description 8
JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 8
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 7
239000011775 sodium fluoride Substances 0.000 description 7
235000013024 sodium fluoride Nutrition 0.000 description 7
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 6
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 6
239000001768 carboxy methyl cellulose Substances 0.000 description 6
238000002360 preparation method Methods 0.000 description 6
210000003296 saliva Anatomy 0.000 description 6
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 6
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 6
235000019333 sodium laurylsulphate Nutrition 0.000 description 6
235000019606 astringent taste Nutrition 0.000 description 5
230000000694 effects Effects 0.000 description 5
239000012071 phase Substances 0.000 description 5
229910052708 sodium Inorganic materials 0.000 description 5
239000011734 sodium Substances 0.000 description 5
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 4
230000000052 comparative effect Effects 0.000 description 4
230000014759 maintenance of location Effects 0.000 description 4
239000003921 oil Substances 0.000 description 4
239000000600 sorbitol Substances 0.000 description 4
150000003751 zinc Chemical class 0.000 description 4
239000011592 zinc chloride Substances 0.000 description 4
235000005074 zinc chloride Nutrition 0.000 description 4
206010013911 Dysgeusia Diseases 0.000 description 3
239000002671 adjuvant Substances 0.000 description 3
230000008901 benefit Effects 0.000 description 3
230000001680 brushing effect Effects 0.000 description 3
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
150000001875 compounds Chemical class 0.000 description 3
LRCFXGAMWKDGLA-UHFFFAOYSA-N dioxosilane;hydrate Chemical compound O.O=[Si]=O LRCFXGAMWKDGLA-UHFFFAOYSA-N 0.000 description 3
229920000642 polymer Polymers 0.000 description 3
239000000843 powder Substances 0.000 description 3
239000000523 sample Substances 0.000 description 3
229960004029 silicic acid Drugs 0.000 description 3
KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 description 3
230000002459 sustained effect Effects 0.000 description 3
AEQDJSLRWYMAQI-UHFFFAOYSA-N 2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline Chemical compound C1CN2CC(C(=C(OC)C=C3)OC)=C3CC2C2=C1C=C(OC)C(OC)=C2 AEQDJSLRWYMAQI-UHFFFAOYSA-N 0.000 description 2
SGHZXLIDFTYFHQ-UHFFFAOYSA-L Brilliant Blue Chemical compound [Na+].[Na+].C=1C=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C(=CC=CC=2)S([O-])(=O)=O)C=CC=1N(CC)CC1=CC=CC(S([O-])(=O)=O)=C1 SGHZXLIDFTYFHQ-UHFFFAOYSA-L 0.000 description 2
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 2
GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
150000001412 amines Chemical class 0.000 description 2
235000001014 amino acid Nutrition 0.000 description 2
150000001413 amino acids Chemical class 0.000 description 2
229920006318 anionic polymer Polymers 0.000 description 2
239000003242 anti bacterial agent Substances 0.000 description 2
230000002882 anti-plaque Effects 0.000 description 2
239000003086 colorant Substances 0.000 description 2
239000008139 complexing agent Substances 0.000 description 2
230000007423 decrease Effects 0.000 description 2
230000001419 dependent effect Effects 0.000 description 2
238000011161 development Methods 0.000 description 2
230000018109 developmental process Effects 0.000 description 2
229910052751 metal Inorganic materials 0.000 description 2
239000002184 metal Substances 0.000 description 2
238000002156 mixing Methods 0.000 description 2
230000035515 penetration Effects 0.000 description 2
229920001992 poloxamer 407 Polymers 0.000 description 2
229940044476 poloxamer 407 Drugs 0.000 description 2
229920001223 polyethylene glycol Polymers 0.000 description 2
108700004121 sarkosyl Proteins 0.000 description 2
WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 2
235000010234 sodium benzoate Nutrition 0.000 description 2
239000004299 sodium benzoate Substances 0.000 description 2
239000000176 sodium gluconate Substances 0.000 description 2
235000012207 sodium gluconate Nutrition 0.000 description 2
229940005574 sodium gluconate Drugs 0.000 description 2
229940045885 sodium lauroyl sarcosinate Drugs 0.000 description 2
239000000725 suspension Substances 0.000 description 2
IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
MSJBLPVXRJMJSY-UHFFFAOYSA-N 2,6-bis(2-ethylhexyl)-7a-methyl-1,3,5,7-tetrahydroimidazo[1,5-c]imidazole Chemical compound C1N(CC(CC)CCCC)CC2(C)CN(CC(CC)CCCC)CN21 MSJBLPVXRJMJSY-UHFFFAOYSA-N 0.000 description 1
FZZMTSNZRBFGGU-UHFFFAOYSA-N 2-chloro-7-fluoroquinazolin-4-amine Chemical group FC1=CC=C2C(N)=NC(Cl)=NC2=C1 FZZMTSNZRBFGGU-UHFFFAOYSA-N 0.000 description 1
XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 1
PNEYBMLMFCGWSK-UHFFFAOYSA-N Alumina Chemical compound [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
206010006326 Breath odour Diseases 0.000 description 1
208000004434 Calcinosis Diseases 0.000 description 1
BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 description 1
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
UDIPTWFVPPPURJ-UHFFFAOYSA-M Cyclamate Chemical compound [Na+].[O-]S(=O)(=O)NC1CCCCC1 UDIPTWFVPPPURJ-UHFFFAOYSA-M 0.000 description 1
IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
239000004471 Glycine Substances 0.000 description 1
239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
235000014749 Mentha crispa Nutrition 0.000 description 1
244000246386 Mentha pulegium Species 0.000 description 1
235000016257 Mentha pulegium Nutrition 0.000 description 1
244000078639 Mentha spicata Species 0.000 description 1
235000004357 Mentha x piperita Nutrition 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
108010039918 Polylysine Proteins 0.000 description 1
239000004743 Polypropylene Substances 0.000 description 1
241000176725 Pyrops Species 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
208000025371 Taste disease Diseases 0.000 description 1
239000003082 abrasive agent Substances 0.000 description 1
239000002253 acid Substances 0.000 description 1
239000012445 acidic reagent Substances 0.000 description 1
239000004480 active ingredient Substances 0.000 description 1
239000003513 alkali Substances 0.000 description 1
150000001340 alkali metals Chemical class 0.000 description 1
125000000217 alkyl group Chemical group 0.000 description 1
125000003277 amino group Chemical group 0.000 description 1
229920005550 ammonium lignosulfonate Polymers 0.000 description 1
239000005557 antagonist Substances 0.000 description 1
230000000845 anti-microbial effect Effects 0.000 description 1
239000004599 antimicrobial Substances 0.000 description 1
239000012736 aqueous medium Substances 0.000 description 1
239000008346 aqueous phase Substances 0.000 description 1
239000007900 aqueous suspension Substances 0.000 description 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
230000009286 beneficial effect Effects 0.000 description 1
239000011230 binding agent Substances 0.000 description 1
230000033558 biomineral tissue development Effects 0.000 description 1
230000002051 biphasic effect Effects 0.000 description 1
239000007844 bleaching agent Substances 0.000 description 1
239000000872 buffer Substances 0.000 description 1
KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
230000002308 calcification Effects 0.000 description 1
229910001424 calcium ion Inorganic materials 0.000 description 1
239000001506 calcium phosphate Substances 0.000 description 1
229910000389 calcium phosphate Inorganic materials 0.000 description 1
235000011010 calcium phosphates Nutrition 0.000 description 1
150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 1
229960001927 cetylpyridinium chloride Drugs 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
239000013626 chemical specie Substances 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
230000001055 chewing effect Effects 0.000 description 1
ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical class C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 description 1
239000007859 condensation product Substances 0.000 description 1
239000000625 cyclamic acid and its Na and Ca salt Substances 0.000 description 1
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238000013461 design Methods 0.000 description 1
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VTIIJXUACCWYHX-UHFFFAOYSA-L disodium;carboxylatooxy carbonate Chemical compound [Na+].[Na+].[O-]C(=O)OOC([O-])=O VTIIJXUACCWYHX-UHFFFAOYSA-L 0.000 description 1
GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 description 1
230000035622 drinking Effects 0.000 description 1
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238000011156 evaluation Methods 0.000 description 1
239000000194 fatty acid Substances 0.000 description 1
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150000004665 fatty acids Chemical class 0.000 description 1
150000002191 fatty alcohols Chemical class 0.000 description 1
239000012467 final product Substances 0.000 description 1
150000002222 fluorine compounds Chemical class 0.000 description 1
235000003599 food sweetener Nutrition 0.000 description 1
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239000003349 gelling agent Substances 0.000 description 1
125000005842 heteroatom Chemical group 0.000 description 1
229950004575 hexedine Drugs 0.000 description 1
235000001050 hortel pimenta Nutrition 0.000 description 1
239000003906 humectant Substances 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
238000000338 in vitro Methods 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
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150000002500 ions Chemical class 0.000 description 1
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239000002609 medium Substances 0.000 description 1
239000012528 membrane Substances 0.000 description 1
235000019656 metallic taste Nutrition 0.000 description 1
230000000813 microbial effect Effects 0.000 description 1
235000010755 mineral Nutrition 0.000 description 1
239000011707 mineral Substances 0.000 description 1
150000007522 mineralic acids Chemical class 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
229940023486 oral product Drugs 0.000 description 1
239000013588 oral product Substances 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
239000001301 oxygen Substances 0.000 description 1
229910052760 oxygen Inorganic materials 0.000 description 1
235000019629 palatability Nutrition 0.000 description 1
230000008447 perception Effects 0.000 description 1
230000035699 permeability Effects 0.000 description 1
ABLZXFCXXLZCGV-UHFFFAOYSA-N phosphonic acid group Chemical group P(O)(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 description 1
229920000724 poly(L-arginine) polymer Polymers 0.000 description 1
108010011110 polyarginine Proteins 0.000 description 1
229920002704 polyhistidine Polymers 0.000 description 1
229920000656 polylysine Polymers 0.000 description 1
229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
229920001155 polypropylene Polymers 0.000 description 1
229920001296 polysiloxane Polymers 0.000 description 1
239000004800 polyvinyl chloride Substances 0.000 description 1
229920000915 polyvinyl chloride Polymers 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
150000003141 primary amines Chemical class 0.000 description 1
WQGWDDDVZFFDIG-UHFFFAOYSA-N pyrogallol Chemical compound OC1=CC=CC(O)=C1O WQGWDDDVZFFDIG-UHFFFAOYSA-N 0.000 description 1
230000000979 retarding effect Effects 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
125000000467 secondary amino group Chemical class [H]N([*:1])[*:2] 0.000 description 1
230000014860 sensory perception of taste Effects 0.000 description 1
229910002028 silica xerogel Inorganic materials 0.000 description 1
239000000661 sodium alginate Substances 0.000 description 1
235000010413 sodium alginate Nutrition 0.000 description 1
229940005550 sodium alginate Drugs 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
229960001462 sodium cyclamate Drugs 0.000 description 1
229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 description 1
229960004711 sodium monofluorophosphate Drugs 0.000 description 1
229940045872 sodium percarbonate Drugs 0.000 description 1
230000003381 solubilizing effect Effects 0.000 description 1
235000019614 sour taste Nutrition 0.000 description 1
238000002798 spectrophotometry method Methods 0.000 description 1
239000000126 substance Substances 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
229910052717 sulfur Chemical group 0.000 description 1
239000011593 sulfur Chemical group 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
235000019640 taste Nutrition 0.000 description 1
150000003512 tertiary amines Chemical group 0.000 description 1
239000004408 titanium dioxide Substances 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
UGZADUVQMDAIAO-UHFFFAOYSA-L zinc hydroxide Chemical class [OH-].[OH-].[Zn+2] UGZADUVQMDAIAO-UHFFFAOYSA-L 0.000 description 1
229940118827 zinc phenolsulfonate Drugs 0.000 description 1
CMYYIMKYBISJPZ-UHFFFAOYSA-L zinc;2-(carboxymethyl)butanedioate Chemical compound [Zn+2].OC(=O)CC(C([O-])=O)CC([O-])=O CMYYIMKYBISJPZ-UHFFFAOYSA-L 0.000 description 1
BOVNWDGXGNVNQD-UHFFFAOYSA-L zinc;2-hydroxybenzenesulfonate Chemical compound [Zn+2].OC1=CC=CC=C1S([O-])(=O)=O.OC1=CC=CC=C1S([O-])(=O)=O BOVNWDGXGNVNQD-UHFFFAOYSA-L 0.000 description 1

Landscapes

Cosmetics (AREA)

CA 2154860 1994-07-26 1995-07-24 Produits pour soins buccaux, a base de complexe de zinc-polyamine et de pyrophosphate Abandoned CA2154860A1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US28041194A	1994-07-26	1994-07-26
US08/280,411		1994-07-26

Publications (1)

Publication Number	Publication Date
CA2154860A1 true CA2154860A1 (fr)	1996-01-27

Family

ID=23072965

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA 2154860 Abandoned CA2154860A1 (fr)	1994-07-26	1995-07-24	Produits pour soins buccaux, a base de complexe de zinc-polyamine et de pyrophosphate

Country Status (1)

Country	Link
CA (1)	CA2154860A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6607711B2 (en)	1997-10-07	2003-08-19	Ejvind Jersie Pedersen	Mouth hygienic composition for the treatment of halitosis
WO2013171164A1 (fr)	2012-05-14	2013-11-21	EJP Pharmaceutical ApS	Compositions et formulations pour le traitement de l'halitose
WO2015041523A1 (fr)	2013-09-18	2015-03-26	Glymur B.V.	Compositions d'hygiène buccale
EP1910250B1 (fr) *	2005-07-12	2016-03-30	Adelaide Research & Innovation Pty Ltd.	Chélateurs pour engrais à base de micronutriments
US10179038B2 (en)	2015-12-30	2019-01-15	Colgate-Palmolive Company	Oral care device with sacrificial electrode
US11019918B2 (en)	2018-06-11	2021-06-01	Colgate-Palmolive Company	Oral care device
US11241084B2 (en)	2018-06-11	2022-02-08	Colgate-Palmolive Company	Oral care device

1995
- 1995-07-24 CA CA 2154860 patent/CA2154860A1/fr not_active Abandoned

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6607711B2 (en)	1997-10-07	2003-08-19	Ejvind Jersie Pedersen	Mouth hygienic composition for the treatment of halitosis
EP1910250B1 (fr) *	2005-07-12	2016-03-30	Adelaide Research & Innovation Pty Ltd.	Chélateurs pour engrais à base de micronutriments
WO2013171164A1 (fr)	2012-05-14	2013-11-21	EJP Pharmaceutical ApS	Compositions et formulations pour le traitement de l'halitose
WO2015041523A1 (fr)	2013-09-18	2015-03-26	Glymur B.V.	Compositions d'hygiène buccale
US10179038B2 (en)	2015-12-30	2019-01-15	Colgate-Palmolive Company	Oral care device with sacrificial electrode
US10932893B2 (en)	2015-12-30	2021-03-02	Colgate-Palmolive Company	Oral care device with sacrificial electrode
US12251284B2 (en)	2015-12-30	2025-03-18	Colgate-Palmolive Company	Oral care device with sacrificial electrode
US11019918B2 (en)	2018-06-11	2021-06-01	Colgate-Palmolive Company	Oral care device
US11241084B2 (en)	2018-06-11	2022-02-08	Colgate-Palmolive Company	Oral care device
US11712108B2 (en)	2018-06-11	2023-08-01	Colgate-Palmolive Company	Oral care process
US11786034B2 (en)	2018-06-11	2023-10-17	Colgate-Palmolive Company	Oral care device

Legal Events

Date	Code	Title	Description
1998-03-16	FZDE	Dead

Publication	Publication Date	Title
KR890002946B1 (ko)	1989-08-14	구강 위생 조성물
CA2169460C (fr)	1999-07-20	Compositions orales renfermant des composes stanneux
AU2012396297B2 (en)	2015-08-20	Surfactant systems for zinc containing compositions
AU3275193A (en)	1993-07-19	Oral compositions for suppressing mouth odors
CZ156895A3 (en)	1996-01-17	Mouth preparation containing agents against formation of microbial plaque and tartar
CN1373652A (zh)	2002-10-09	含有茶多酚的口腔用组合物
EA002367B1 (ru)	2002-04-25	Состав для ухода за полостью рта
US5587147A (en)	1996-12-24	Aqueous zinc-polyamide complex solution
EP0626843A1 (fr)	1994-12-07	Utilisation de la polyvinylpyrrolidone pour reduire l'adherence des bacteries buccales.
JPH02286613A (ja)	1990-11-26	新規組成物
WO2012064339A1 (fr)	2012-05-18	Produit de soin buccal et procédés d'utilisation et de fabrication de celui-ci
EP0095871A2 (fr)	1983-12-07	Compositions de traitement dentaire
JPH03127719A (ja)	1991-05-30	歯口用組成物
CA2785578C (fr)	2015-03-17	Compositions de dentifrice comprenant une carboxypeptidase
US20010031245A1 (en)	2001-10-18	Compositions
RU2743997C2 (ru)	2021-03-01	Композиции для ухода за полостью рта
CA2754213C (fr)	2014-09-23	Dentifrice desensibilisant presentant une absorption d'agent antibacterien pour tissu dentaire
AU2021232731B2 (en)	2022-10-20	Oral composition
CA2152982A1 (fr)	1995-12-31	Produits renfermant un complexe de zinc-polyamine pour soins buccaux
WO2009010381A1 (fr)	2009-01-22	Composition de dentifrice
US20090010859A1 (en)	2009-01-08	Oral Composition
JP3877412B2 (ja)	2007-02-07	液体口腔用組成物
EP0906085A1 (fr)	1999-04-07	Compositions
KR100416416B1 (ko)	2004-01-31	적당한 양치시간을 알 수 있게 해 주는 치약조성물
JP2015227362A (ja)	2015-12-17	減少した収斂性を有する歯磨剤組成物