CA2155107C - Dispositif d'administration de medicament actif et methode de preparation - Google Patents

Dispositif d'administration de medicament actif et methode de preparation Download PDF

Info

Publication number: CA2155107C
Authority: CA; Canada
Prior art keywords: flexible; area; electrode; silver; metal
Prior art date: 1993-02-02
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

CA002155107A

Other languages

English (en)

Other versions

CA2155107A1 (fr

Inventor

Norman A. Jacobs

John D. Denuzzio

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Vyteris Inc

Original Assignee

Becton Dickinson and Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-02-02

Filing date

1994-02-01

Publication date

2000-09-19

1994-02-01 Application filed by Becton Dickinson and Co filed Critical Becton Dickinson and Co

1994-08-18 Publication of CA2155107A1 publication Critical patent/CA2155107A1/fr

2000-09-19 Application granted granted Critical

2000-09-19 Publication of CA2155107C publication Critical patent/CA2155107C/fr

2014-02-01 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

238000012377 drug delivery Methods 0.000 title claims abstract description 9
238000000034 method Methods 0.000 title claims description 37
229910052751 metal Inorganic materials 0.000 claims abstract description 73
239000002184 metal Substances 0.000 claims abstract description 73
229910052709 silver Inorganic materials 0.000 claims abstract description 59
239000004332 silver Substances 0.000 claims abstract description 59
BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims abstract description 57
-1 halogen salt Chemical class 0.000 claims abstract description 19
RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims abstract description 18
229910052802 copper Inorganic materials 0.000 claims abstract description 18
239000010949 copper Substances 0.000 claims abstract description 18
ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 claims abstract description 17
229910052750 molybdenum Inorganic materials 0.000 claims abstract description 17
239000011733 molybdenum Substances 0.000 claims abstract description 17
229910052736 halogen Inorganic materials 0.000 claims abstract description 5
238000004891 communication Methods 0.000 claims abstract description 4
239000000976 ink Substances 0.000 claims description 45
239000003814 drug Substances 0.000 claims description 37
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 9
229910002804 graphite Inorganic materials 0.000 claims description 9
239000010439 graphite Substances 0.000 claims description 9
239000000463 material Substances 0.000 claims description 9
229910021607 Silver chloride Inorganic materials 0.000 claims description 8
HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 claims description 8
238000005530 etching Methods 0.000 claims description 3
238000001459 lithography Methods 0.000 claims description 3
230000003213 activating effect Effects 0.000 claims description 2
229920002120 photoresistant polymer Polymers 0.000 claims description 2
150000002500 ions Chemical class 0.000 description 13
229940079593 drug Drugs 0.000 description 10
239000011888 foil Substances 0.000 description 10
230000008569 process Effects 0.000 description 9
239000004020 conductor Substances 0.000 description 7
238000004519 manufacturing process Methods 0.000 description 6
238000013461 design Methods 0.000 description 5
238000005868 electrolysis reaction Methods 0.000 description 5
239000000126 substance Substances 0.000 description 5
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 4
FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 description 4
230000008901 benefit Effects 0.000 description 4
230000000712 assembly Effects 0.000 description 3
238000000429 assembly Methods 0.000 description 3
125000002091 cationic group Chemical group 0.000 description 3
150000001768 cations Chemical class 0.000 description 3
238000010348 incorporation Methods 0.000 description 3
239000002244 precipitate Substances 0.000 description 3
230000002459 sustained effect Effects 0.000 description 3
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
238000010521 absorption reaction Methods 0.000 description 2
239000000853 adhesive Substances 0.000 description 2
230000001070 adhesive effect Effects 0.000 description 2
230000015572 biosynthetic process Effects 0.000 description 2
230000002708 enhancing effect Effects 0.000 description 2
229910052739 hydrogen Inorganic materials 0.000 description 2
239000001257 hydrogen Substances 0.000 description 2
238000003801 milling Methods 0.000 description 2
230000036961 partial effect Effects 0.000 description 2
230000002829 reductive effect Effects 0.000 description 2
230000037317 transdermal delivery Effects 0.000 description 2
238000013271 transdermal drug delivery Methods 0.000 description 2
SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 1
208000009043 Chemical Burns Diseases 0.000 description 1
206010069808 Electrical burn Diseases 0.000 description 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 description 1
239000000006 Nitroglycerin Substances 0.000 description 1
239000002033 PVDF binder Substances 0.000 description 1
239000004698 Polyethylene Substances 0.000 description 1
230000002378 acidificating effect Effects 0.000 description 1
125000000129 anionic group Chemical group 0.000 description 1
150000001450 anions Chemical class 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
150000003841 chloride salts Chemical class 0.000 description 1
230000002860 competitive effect Effects 0.000 description 1
230000000295 complement effect Effects 0.000 description 1
238000010276 construction Methods 0.000 description 1
238000009792 diffusion process Methods 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
230000000694 effects Effects 0.000 description 1
239000008151 electrolyte solution Substances 0.000 description 1
238000005370 electroosmosis Methods 0.000 description 1
238000001962 electrophoresis Methods 0.000 description 1
238000009713 electroplating Methods 0.000 description 1
229940011871 estrogen Drugs 0.000 description 1
239000000262 estrogen Substances 0.000 description 1
210000001035 gastrointestinal tract Anatomy 0.000 description 1
229960003711 glyceryl trinitrate Drugs 0.000 description 1
150000004820 halides Chemical class 0.000 description 1
230000035876 healing Effects 0.000 description 1
150000003840 hydrochlorides Chemical class 0.000 description 1
230000006872 improvement Effects 0.000 description 1
230000037427 ion transport Effects 0.000 description 1
230000000873 masking effect Effects 0.000 description 1
150000002739 metals Chemical class 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
210000004400 mucous membrane Anatomy 0.000 description 1
229960002715 nicotine Drugs 0.000 description 1
SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 1
239000003921 oil Substances 0.000 description 1
230000003647 oxidation Effects 0.000 description 1
238000007254 oxidation reaction Methods 0.000 description 1
239000003973 paint Substances 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
229920000139 polyethylene terephthalate Polymers 0.000 description 1
239000005020 polyethylene terephthalate Substances 0.000 description 1
229920000915 polyvinyl chloride Polymers 0.000 description 1
239000004800 polyvinyl chloride Substances 0.000 description 1
229920002981 polyvinylidene fluoride Polymers 0.000 description 1
239000002243 precursor Substances 0.000 description 1
238000007639 printing Methods 0.000 description 1
230000001681 protective effect Effects 0.000 description 1
230000027756 respiratory electron transport chain Effects 0.000 description 1
238000007650 screen-printing Methods 0.000 description 1
229940054334 silver cation Drugs 0.000 description 1
239000000243 solution Substances 0.000 description 1
238000004544 sputter deposition Methods 0.000 description 1
238000000992 sputter etching Methods 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
238000012546 transfer Methods 0.000 description 1
230000032258 transport Effects 0.000 description 1
239000002699 waste material Substances 0.000 description 1
230000037303 wrinkles Effects 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0432—Anode and cathode
- A61N1/044—Shape of the electrode
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0432—Anode and cathode
- A61N1/0436—Material of the electrode
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0448—Drug reservoir

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Biomedical Technology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Radiology & Medical Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Electrotherapy Devices (AREA)
Manufacturing Of Printed Wiring (AREA)

CA002155107A 1993-02-02 1994-02-01 Dispositif d'administration de medicament actif et methode de preparation Expired - Fee Related CA2155107C (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US1216893A	1993-02-02	1993-02-02
US08/012,168		1993-02-02
PCT/US1994/001152 WO1994017853A1 (fr)	1993-02-02	1994-02-01	Dispositif, electrode de liberation de medicament et leur procede de fabrication

Publications (2)

Publication Number	Publication Date
CA2155107A1 CA2155107A1 (fr)	1994-08-18
CA2155107C true CA2155107C (fr)	2000-09-19

Family

ID=21753694

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002155107A Expired - Fee Related CA2155107C (fr)	1993-02-02	1994-02-01	Dispositif d'administration de medicament actif et methode de preparation

Country Status (4)

Country	Link
EP (1)	EP0682541A4 (fr)
AU (1)	AU6100194A (fr)
CA (1)	CA2155107C (fr)
WO (1)	WO1994017853A1 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU7254496A (en) *	1995-09-29	1997-04-17	Becton Dickinson & Company	Low-cost electrodes for an iontophoretic device
US5792097A (en)	1996-09-27	1998-08-11	Becton Dickinson And Company	Iontophoretic electrodes and surface active agents
US6157858A (en) *	1996-12-26	2000-12-05	Elan Pharma International Limited	Device for the delivery of a substance to a subject and improved electrode assembly
AU5337998A (en) *	1996-12-26	1998-07-31	Elan International Services Limited	Device for the delivery of a substance to a subject and improved electrode assembly
IE970557A1 (en) *	1996-12-26	1998-07-01	Elan Med Tech	Device for the delivery of a substance to a subject and¹improved electrode assembly
US6078842A (en) *	1997-04-08	2000-06-20	Elan Corporation, Plc	Electrode and iontophoretic device and method
CA2308489A1 (fr)	1997-10-09	1999-04-22	Emory University	Procede et dispositif d'administration transdermique du lithium
ATE279232T1 (de)	1998-01-28	2004-10-15	Alza Corp	Iontophoretische elektrodenvorrichtung mit geringem anfangswiderstand
US7476222B2 (en)	2003-06-30	2009-01-13	Johnson & Johnson Consumer Companies, Inc.	Methods of reducing the appearance of pigmentation with galvanic generated electricity
US7486989B2 (en)	2003-06-30	2009-02-03	Johnson & Johnson Consumer Companies, Inc.	Device for delivery of oxidizing agents to barrier membranes
US7477938B2 (en)	2003-06-30	2009-01-13	Johnson & Johnson Cosumer Companies, Inc.	Device for delivery of active agents to barrier membranes
US7477941B2 (en)	2003-06-30	2009-01-13	Johnson & Johnson Consumer Companies, Inc.	Methods of exfoliating the skin with electricity
US7477940B2 (en)	2003-06-30	2009-01-13	J&J Consumer Companies, Inc.	Methods of administering an active agent to a human barrier membrane with galvanic generated electricity
US7507228B2 (en)	2003-06-30	2009-03-24	Johnson & Johnson Consumer Companies, Inc.	Device containing a light emitting diode for treatment of barrier membranes
US7479133B2 (en)	2003-06-30	2009-01-20	Johnson & Johnson Consumer Companies, Inc.	Methods of treating acne and rosacea with galvanic generated electricity
US7480530B2 (en)	2003-06-30	2009-01-20	Johnson & Johnson Consumer Companies, Inc.	Device for treatment of barrier membranes
US8734421B2 (en)	2003-06-30	2014-05-27	Johnson & Johnson Consumer Companies, Inc.	Methods of treating pores on the skin with electricity
US8150525B2 (en)	2008-08-27	2012-04-03	Johnson & Johnson Consumer Companies, Inc.	Treatment of hyperhydrosis
US20120089232A1 (en)	2009-03-27	2012-04-12	Jennifer Hagyoung Kang Choi	Medical devices with galvanic particulates
AU2010319733B2 (en)	2009-11-13	2014-08-07	Johnson & Johnson Consumer Companies, Inc.	Galvanic skin treatment device
DK3030286T3 (da)	2013-08-05	2019-11-11	Cam Med Llc	Komfortabel patch-pumpe

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4820263A (en) *	1981-03-06	1989-04-11	Medtronic, Inc.	Apparatus and method for iontophoretic drug delivery
US4883457A (en) *	1983-08-18	1989-11-28	Drug Delivery Systems Inc.	Disposable and/or replenishable transdermal drug applicators and methods of manufacturing same
US4744787A (en) *	1984-10-29	1988-05-17	Medtronic, Inc.	Iontophoresis apparatus and methods of producing same
US4635641A (en) *	1985-10-16	1987-01-13	Murray Electronics Associates Limited	Multi-element electrode
US4752285B1 (en) *	1986-03-19	1995-08-22	Univ Utah Res Found	Methods and apparatus for iontophoresis application of medicaments
IL86076A (en) *	1988-04-14	1992-12-01	Inventor S Funding Corp Ltd	Transdermal drug delivery device
US5254081A (en) *	1991-02-01	1993-10-19	Empi, Inc.	Multiple site drug iontophoresis electronic device and method

1994
- 1994-02-01 CA CA002155107A patent/CA2155107C/fr not_active Expired - Fee Related
- 1994-02-01 EP EP94907398A patent/EP0682541A4/fr not_active Withdrawn
- 1994-02-01 WO PCT/US1994/001152 patent/WO1994017853A1/fr not_active Ceased
- 1994-02-01 AU AU61001/94A patent/AU6100194A/en not_active Abandoned

Also Published As

Publication number	Publication date
CA2155107A1 (fr)	1994-08-18
AU6100194A (en)	1994-08-29
WO1994017853A1 (fr)	1994-08-18
EP0682541A4 (fr)	1996-03-27
EP0682541A1 (fr)	1995-11-22

Legal Events

Date	Code	Title	Description
1995-07-31	EEER	Examination request
2002-02-01	MKLA	Lapsed

Publication	Publication Date	Title
CA2155107C (fr)	2000-09-19	Dispositif d'administration de medicament actif et methode de preparation
US6757560B1 (en)	2004-06-29	Transdermal delivery system (TDS) with electrode network
EP0400118B1 (fr)	1996-11-20	Electrode d'iontophorese
KR100194851B1 (ko)	1999-06-15	이온삼투요법용 장치
US5084008A (en)	1992-01-28	Iontophoresis electrode
KR100601776B1 (ko)	2006-07-19	전해질 경피 전달 장치를 위한 무수 약물 저장기
US5057072A (en)	1991-10-15	Iontophoresis electrode
EP1294439B1 (fr)	2007-08-15	Electrode-reservoir ionophoretique stable au stockage et systeme ionophoretique comprenant cette electrode-reservoir
AU694371B2 (en)	1998-07-16	Electrotransport agent delivery method and apparatus
AU5676790A (en)	1991-12-31	Method and apparatus for iontophoretic drug delivery
WO2000012172A1 (fr)	2000-03-09	Systeme d'administration commandee de dose de medicament
EP0630277A1 (fr)	1994-12-28	Dispositif electrochimique d'administration de medicaments
KR20090064422A (ko)	2009-06-18	유도 전원 공급기들을 사용하는 경피성 약물 전달 시스템, 장치, 및 방법
US5766144A (en)	1998-06-16	High efficiency electrode system for iontophoresis
EP0429552B1 (fr)	1996-11-27	Electrode d'iontophorese
EP1457233A1 (fr)	2004-09-15	Système d'administration de médicaments transdermique avec electrode à mailles
JP2821267B2 (ja)	1998-11-05	イオン導入法によって薬剤を供給する装置および方法
CA2218715C (fr)	2006-06-13	Procede et appareil d'administration d'agents par electrotransport
JP2008167995A (ja)	2008-07-24	印刷電極部材およびイオントフォレーシス装置
JP2008110056A (ja)	2008-05-15	電極部材および電極部材を含むイオントフォレーシス装置
JPWO1995000200A1 (ja)	1995-09-07	イオントフォレーゼ用デバイス
JP2007089776A (ja)	2007-04-12	低周波治療器