CA2159481C - Composes tetracycliques, agonistes de la dopamine - Google Patents

Composes tetracycliques, agonistes de la dopamine Download PDF

Info

Publication number: CA2159481C
Authority: CA; Canada
Prior art keywords: hexahydro; cyclopenta; phenanthrene; aza; diol
Prior art date: 1993-04-06
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

CA002159481A

Other languages

English (en)

Other versions

CA2159481A1 (fr

Inventor

Michael R. Michaelides

Yufeng Hong

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

AbbVie Inc

Original Assignee

Abbott Laboratories

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-04-06

Filing date

1994-03-18

Publication date

2005-12-20

1994-03-18 Application filed by Abbott Laboratories filed Critical Abbott Laboratories

1994-03-18 Priority claimed from PCT/US1994/002894 external-priority patent/WO1994022858A1/fr

1994-10-13 Publication of CA2159481A1 publication Critical patent/CA2159481A1/fr

2005-12-20 Application granted granted Critical

2005-12-20 Publication of CA2159481C publication Critical patent/CA2159481C/fr

2014-03-18 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

150000001875 compounds Chemical class 0.000 title claims abstract description 194
239000003136 dopamine receptor stimulating agent Substances 0.000 title description 21
229940052760 dopamine agonists Drugs 0.000 title description 12
230000000926 neurological effect Effects 0.000 claims abstract description 9
201000009032 substance abuse Diseases 0.000 claims abstract description 9
208000011117 substance-related disease Diseases 0.000 claims abstract description 9
231100000736 substance abuse Toxicity 0.000 claims abstract description 8
VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 claims description 112
229960003638 dopamine Drugs 0.000 claims description 55
239000003814 drug Substances 0.000 claims description 28
229910052739 hydrogen Inorganic materials 0.000 claims description 20
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 19
239000001257 hydrogen Substances 0.000 claims description 19
208000035475 disorder Diseases 0.000 claims description 18
150000003839 salts Chemical class 0.000 claims description 16
YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims description 12
150000002148 esters Chemical class 0.000 claims description 12
150000002431 hydrogen Chemical group 0.000 claims description 12
230000003291 dopaminomimetic effect Effects 0.000 claims description 11
229910052717 sulfur Inorganic materials 0.000 claims description 10
125000004429 atom Chemical group 0.000 claims description 8
125000004122 cyclic group Chemical group 0.000 claims description 8
229910052760 oxygen Chemical group 0.000 claims description 8
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125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 4
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238000005406 washing Methods 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1
235000016804 zinc Nutrition 0.000 description 1
239000011787 zinc oxide Substances 0.000 description 1
235000014692 zinc oxide Nutrition 0.000 description 1
239000002076 α-tocopherol Substances 0.000 description 1
235000004835 α-tocopherol Nutrition 0.000 description 1

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Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

CA002159481A 1993-04-06 1994-03-18 Composes tetracycliques, agonistes de la dopamine Expired - Lifetime CA2159481C (fr)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US4342493A	1993-04-06	1993-04-06
US08/043,424		1993-04-06
US20998294A	1994-03-17	1994-03-17
US08/209,982		1994-03-17
PCT/US1994/002894 WO1994022858A1 (fr)	1993-04-06	1994-03-18	Composes tetracycliques agonistes de la dopamine

Publications (2)

Publication Number	Publication Date
CA2159481A1 CA2159481A1 (fr)	1994-10-13
CA2159481C true CA2159481C (fr)	2005-12-20

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1994
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