CA2174731C - Derives de rapamycine utilises comme immonosuppresseurs - Google Patents

Derives de rapamycine utilises comme immonosuppresseurs Download PDF

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Publication number
CA2174731C
CA2174731C CA002174731A CA2174731A CA2174731C CA 2174731 C CA2174731 C CA 2174731C CA 002174731 A CA002174731 A CA 002174731A CA 2174731 A CA2174731 A CA 2174731A CA 2174731 C CA2174731 C CA 2174731C
Authority
CA
Canada
Prior art keywords
rapamycin
formula
iii
alkyl
compound according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002174731A
Other languages
English (en)
Other versions
CA2174731A1 (fr
Inventor
Sylvain Cottens
Richard Sedrani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939325802A external-priority patent/GB9325802D0/en
Priority claimed from GB939325800A external-priority patent/GB9325800D0/en
Priority claimed from GB9407138A external-priority patent/GB9407138D0/en
Priority claimed from GB9421982A external-priority patent/GB9421982D0/en
Application filed by Novartis AG filed Critical Novartis AG
Priority claimed from PCT/EP1994/004191 external-priority patent/WO1995016691A1/fr
Publication of CA2174731A1 publication Critical patent/CA2174731A1/fr
Application granted granted Critical
Publication of CA2174731C publication Critical patent/CA2174731C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

L'invention concerne des nouveaux dérivés déméthoxy de la rapamycine de formule (I) utiles dans le domaine pharmaceutique, en particulier en tant qu'immunosuppresseurs. Dans cette formule (I), R¿2? est représenté par la formule (II) ou (III). Dans les formules (I), (II) et (III), X, Y, R¿1?, R¿3?, R¿4?, R¿5? sont tels que définis dans la demande.
CA002174731A 1993-12-17 1994-12-16 Derives de rapamycine utilises comme immonosuppresseurs Expired - Fee Related CA2174731C (fr)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
GB9325800.2 1993-12-17
GB939325802A GB9325802D0 (en) 1993-12-17 1993-12-17 Organic compounds
GB939325800A GB9325800D0 (en) 1993-12-17 1993-12-17 Organic compounds
GB9325802.8 1993-12-17
GB9407138A GB9407138D0 (en) 1994-04-11 1994-04-11 Organic compounds
GB9407138.8 1994-04-11
GB9421982.1 1994-11-01
GB9421982A GB9421982D0 (en) 1994-11-01 1994-11-01 Organic compounds
PCT/EP1994/004191 WO1995016691A1 (fr) 1993-12-17 1994-12-16 Derives de rapamycine utilises comme immonosuppresseurs

Publications (2)

Publication Number Publication Date
CA2174731A1 CA2174731A1 (fr) 1995-06-22
CA2174731C true CA2174731C (fr) 2006-10-31

Family

ID=37395713

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002174731A Expired - Fee Related CA2174731C (fr) 1993-12-17 1994-12-16 Derives de rapamycine utilises comme immonosuppresseurs

Country Status (1)

Country Link
CA (1) CA2174731C (fr)

Also Published As

Publication number Publication date
CA2174731A1 (fr) 1995-06-22

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Legal Events

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MKLA Lapsed