CA2176603C - Nouveaux complexes de palladium et leurs procedes d'utilisation dans le traitement des tumeurs et du psoriasis - Google Patents
Nouveaux complexes de palladium et leurs procedes d'utilisation dans le traitement des tumeurs et du psoriasis Download PDFInfo
- Publication number
- CA2176603C CA2176603C CA002176603A CA2176603A CA2176603C CA 2176603 C CA2176603 C CA 2176603C CA 002176603 A CA002176603 A CA 002176603A CA 2176603 A CA2176603 A CA 2176603A CA 2176603 C CA2176603 C CA 2176603C
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- CA
- Canada
- Prior art keywords
- palladium
- complex
- lipoic acid
- solution
- poly
- Prior art date
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- 229960002663 thioctic acid Drugs 0.000 claims abstract description 127
- 229910052763 palladium Inorganic materials 0.000 claims abstract description 69
- AGBQKNBQESQNJD-UHFFFAOYSA-M lipoate Chemical compound [O-]C(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-M 0.000 claims abstract description 55
- 235000019136 lipoic acid Nutrition 0.000 claims abstract description 54
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- RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 claims description 31
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- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical group Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims description 8
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- WXHIJDCHNDBCNY-UHFFFAOYSA-N palladium dihydride Chemical compound [PdH2] WXHIJDCHNDBCNY-UHFFFAOYSA-N 0.000 description 1
- MUJIDPITZJWBSW-UHFFFAOYSA-N palladium(2+) Chemical compound [Pd+2] MUJIDPITZJWBSW-UHFFFAOYSA-N 0.000 description 1
- BHZSLLSDZFAPFH-UHFFFAOYSA-L palladium(2+);difluoride Chemical compound F[Pd]F BHZSLLSDZFAPFH-UHFFFAOYSA-L 0.000 description 1
- YJVFFLUZDVXJQI-UHFFFAOYSA-L palladium(ii) acetate Chemical compound [Pd+2].CC([O-])=O.CC([O-])=O YJVFFLUZDVXJQI-UHFFFAOYSA-L 0.000 description 1
- JKDRQYIYVJVOPF-FDGPNNRMSA-L palladium(ii) acetylacetonate Chemical compound [Pd+2].C\C([O-])=C\C(C)=O.C\C([O-])=C\C(C)=O JKDRQYIYVJVOPF-FDGPNNRMSA-L 0.000 description 1
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- ZMRUPTIKESYGQW-UHFFFAOYSA-N propranolol hydrochloride Chemical compound [H+].[Cl-].C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 ZMRUPTIKESYGQW-UHFFFAOYSA-N 0.000 description 1
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- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
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- AGGKEGLBGGJEBZ-UHFFFAOYSA-N tetramethylenedisulfotetramine Chemical compound C1N(S2(=O)=O)CN3S(=O)(=O)N1CN2C3 AGGKEGLBGGJEBZ-UHFFFAOYSA-N 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
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- 229930003231 vitamin Natural products 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/006—Palladium compounds
- C07F15/0066—Palladium compounds without a metal-carbon linkage
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
L'invention se rapporte à de nouveaux complexes palladium-acide lipoïque et à des compositions pharmaceutiques renfermant ces complexes. Ces complexes comprennent (le palladium)m et (l'acide lipoïque)n, m et n valant chacun indépendamment 1 ou 2. L'invention se rapporte également à un procédé de préparation de ces complexes, ainsi qu'à un procédé de traitement des tumeurs et du psoriasis qui consiste à administrer la composition pharmaceutique de la présente invention.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/157,570 US5463093A (en) | 1993-11-26 | 1993-11-26 | Palladium complexes and methods for using same in the treatment of tumors or Psoriasis |
| US08/157,570 | 1993-11-26 | ||
| PCT/US1994/013260 WO1995014466A1 (fr) | 1993-11-26 | 1994-11-17 | Nouveaux complexes de palladium et leurs procedes d'utilisation dans le traitement des tumeurs et du psoriasis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2176603A1 CA2176603A1 (fr) | 1995-06-01 |
| CA2176603C true CA2176603C (fr) | 2007-01-23 |
Family
ID=37684131
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002176603A Expired - Fee Related CA2176603C (fr) | 1993-11-26 | 1994-11-17 | Nouveaux complexes de palladium et leurs procedes d'utilisation dans le traitement des tumeurs et du psoriasis |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2176603C (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114807616B (zh) * | 2022-04-27 | 2023-11-28 | 南京桦冠生物技术有限公司 | 一种从含钯有机废液中回收富集钯的方法 |
-
1994
- 1994-11-17 CA CA002176603A patent/CA2176603C/fr not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2176603A1 (fr) | 1995-06-01 |
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