CA2181072C - Amplificateur de penetration d'estradiol pour administration transcutanee - Google Patents
Amplificateur de penetration d'estradiol pour administration transcutanee Download PDFInfo
- Publication number
- CA2181072C CA2181072C CA002181072A CA2181072A CA2181072C CA 2181072 C CA2181072 C CA 2181072C CA 002181072 A CA002181072 A CA 002181072A CA 2181072 A CA2181072 A CA 2181072A CA 2181072 C CA2181072 C CA 2181072C
- Authority
- CA
- Canada
- Prior art keywords
- acid
- active substance
- reservoir
- patch according
- estradiol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 title claims abstract description 24
- 229960005309 estradiol Drugs 0.000 title claims abstract description 24
- 229930182833 estradiol Natural products 0.000 title claims abstract description 24
- 230000035515 penetration Effects 0.000 title description 7
- 239000003623 enhancer Substances 0.000 title description 4
- 239000013543 active substance Substances 0.000 claims abstract description 45
- 239000010410 layer Substances 0.000 claims abstract description 19
- 239000004820 Pressure-sensitive adhesive Substances 0.000 claims abstract description 14
- 239000003961 penetration enhancing agent Substances 0.000 claims abstract description 9
- 239000000583 progesterone congener Substances 0.000 claims abstract description 8
- 239000011241 protective layer Substances 0.000 claims abstract description 7
- 239000000126 substance Substances 0.000 claims abstract description 7
- 150000001735 carboxylic acids Chemical class 0.000 claims abstract description 5
- 238000013270 controlled release Methods 0.000 claims abstract description 4
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- 230000001225 therapeutic effect Effects 0.000 claims description 7
- 239000002253 acid Substances 0.000 claims description 6
- 229920000642 polymer Polymers 0.000 claims description 6
- OBKXEAXTFZPCHS-UHFFFAOYSA-N 4-phenylbutyric acid Chemical compound OC(=O)CCCC1=CC=CC=C1 OBKXEAXTFZPCHS-UHFFFAOYSA-N 0.000 claims description 4
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims description 4
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- 108090000623 proteins and genes Proteins 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 150000004671 saturated fatty acids Chemical class 0.000 description 1
- 235000003441 saturated fatty acids Nutrition 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 229920006132 styrene block copolymer Polymers 0.000 description 1
- 229920000468 styrene butadiene styrene block copolymer Polymers 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 229940100640 transdermal system Drugs 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Un pansement contenant un principe actif, permettant la distribution contrôlée d'estradiol ou de ses dérivés pharmaceutiquement admissibles, seul ou en combinaison avec des progestatifs provenant d'une couche dorsale, un réservoir associé contenant un principe actif et fabriqué au moyen d'adhésifs et au moins d'un amplificateur de pénétration, et une couche protectrice amovible, est caractérisé par le fait que l'amplificateur de pénétration est choisi parmi des substances à base d'acides carboxyliques.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4400770A DE4400770C1 (de) | 1994-01-13 | 1994-01-13 | Wirkstoffhaltiges Pflaster zur Abgabe von Estradiol mit mindestens einem Penetrationsverstärker, Verfahren zu seiner Herstellung und seine Verwendung |
| DEP4400770.1 | 1994-01-13 | ||
| PCT/EP1995/000032 WO1995019162A1 (fr) | 1994-01-13 | 1995-01-05 | Amplificateur de penetration d'estradiol pour administration transcutanee |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2181072A1 CA2181072A1 (fr) | 1995-07-20 |
| CA2181072C true CA2181072C (fr) | 2006-04-04 |
Family
ID=36143237
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002181072A Expired - Fee Related CA2181072C (fr) | 1994-01-13 | 1995-01-05 | Amplificateur de penetration d'estradiol pour administration transcutanee |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2181072C (fr) |
-
1995
- 1995-01-05 CA CA002181072A patent/CA2181072C/fr not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2181072A1 (fr) | 1995-07-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20130107 |