CA2183952C - Granular product or tablet containing an effervescent system and an active pharmaceutical substance, as well as a method for its preparation - Google Patents

Granular product or tablet containing an effervescent system and an active pharmaceutical substance, as well as a method for its preparation Download PDF

Info

Publication number: CA2183952C
Authority: CA; Canada
Prior art keywords: weight; acid; granular product; tablet; effervescent
Prior art date: 1994-03-01
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

CA002183952A

Other languages

English (en)

French (fr)

Other versions

CA2183952A1 (en

Inventor

Thomas Gergely

Stefan Gergely

Gerhard Gergely

Irmgard Gergely

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Individual

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-03-01

Filing date

1995-02-23

Publication date

2007-01-16

1994-10-26 Priority claimed from EP94203112A external-priority patent/EP0670160B1/en

1995-02-23 Application filed by Individual filed Critical Individual

1995-09-08 Publication of CA2183952A1 publication Critical patent/CA2183952A1/en

2007-01-16 Application granted granted Critical

2007-01-16 Publication of CA2183952C publication Critical patent/CA2183952C/en

2015-02-23 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

239000003814 drug Substances 0.000 title claims description 29
238000002360 preparation method Methods 0.000 title claims description 26
238000000034 method Methods 0.000 title claims description 22
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 140
239000002253 acid Substances 0.000 claims abstract description 72
239000000126 substance Substances 0.000 claims abstract description 66
230000007935 neutral effect Effects 0.000 claims abstract description 48
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 39
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 36
239000013543 active substance Substances 0.000 claims abstract description 35
238000000576 coating method Methods 0.000 claims abstract description 32
BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims abstract description 31
239000013078 crystal Substances 0.000 claims abstract description 31
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims abstract description 30
239000011248 coating agent Substances 0.000 claims abstract description 30
150000007524 organic acids Chemical class 0.000 claims abstract description 28
229960001380 cimetidine Drugs 0.000 claims abstract description 22
CCGSUNCLSOWKJO-UHFFFAOYSA-N cimetidine Chemical compound N#CNC(=N/C)\NCCSCC1=NC=N[C]1C CCGSUNCLSOWKJO-UHFFFAOYSA-N 0.000 claims abstract description 22
239000003513 alkali Substances 0.000 claims abstract description 21
239000007787 solid Substances 0.000 claims abstract description 21
229960005132 cisapride Drugs 0.000 claims abstract description 20
DCSUBABJRXZOMT-IRLDBZIGSA-N cisapride Chemical compound C([C@@H]([C@@H](CC1)NC(=O)C=2C(=CC(N)=C(Cl)C=2)OC)OC)N1CCCOC1=CC=C(F)C=C1 DCSUBABJRXZOMT-IRLDBZIGSA-N 0.000 claims abstract description 20
DCSUBABJRXZOMT-UHFFFAOYSA-N cisapride Natural products C1CC(NC(=O)C=2C(=CC(N)=C(Cl)C=2)OC)C(OC)CN1CCCOC1=CC=C(F)C=C1 DCSUBABJRXZOMT-UHFFFAOYSA-N 0.000 claims abstract description 20
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims abstract description 14
OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 claims abstract description 10
239000011648 beta-carotene Substances 0.000 claims abstract description 10
TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 claims abstract description 10
235000013734 beta-carotene Nutrition 0.000 claims abstract description 10
229960002747 betacarotene Drugs 0.000 claims abstract description 10
OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 claims abstract description 10
150000001720 carbohydrates Chemical class 0.000 claims abstract description 7
239000000416 hydrocolloid Substances 0.000 claims abstract description 7
238000002844 melting Methods 0.000 claims abstract description 7
230000008018 melting Effects 0.000 claims abstract description 7
229960000620 ranitidine Drugs 0.000 claims abstract description 7
VMXUWOKSQNHOCA-LCYFTJDESA-N ranitidine Chemical compound [O-][N+](=O)/C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 VMXUWOKSQNHOCA-LCYFTJDESA-N 0.000 claims abstract description 7
-1 for example Substances 0.000 claims abstract description 6
229920003169 water-soluble polymer Polymers 0.000 claims abstract 5
239000003826 tablet Substances 0.000 claims description 87
239000000047 product Substances 0.000 claims description 65
239000000203 mixture Substances 0.000 claims description 49
CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 46
239000000243 solution Substances 0.000 claims description 40
239000008187 granular material Substances 0.000 claims description 36
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 34
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 28
238000006243 chemical reaction Methods 0.000 claims description 28
239000000600 sorbitol Substances 0.000 claims description 28
235000010356 sorbitol Nutrition 0.000 claims description 28
239000007938 effervescent tablet Substances 0.000 claims description 27
229940079593 drug Drugs 0.000 claims description 26
229910000029 sodium carbonate Inorganic materials 0.000 claims description 22
239000002518 antifoaming agent Substances 0.000 claims description 21
238000002156 mixing Methods 0.000 claims description 21
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 19
229930195725 Mannitol Natural products 0.000 claims description 19
239000011230 binding agent Substances 0.000 claims description 19
239000000594 mannitol Substances 0.000 claims description 19
235000010355 mannitol Nutrition 0.000 claims description 19
229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 17
235000017557 sodium bicarbonate Nutrition 0.000 claims description 16
238000001035 drying Methods 0.000 claims description 15
239000002245 particle Substances 0.000 claims description 14
238000007792 addition Methods 0.000 claims description 12
AMTWCFIAVKBGOD-UHFFFAOYSA-N dioxosilane;methoxy-dimethyl-trimethylsilyloxysilane Chemical compound O=[Si]=O.CO[Si](C)(C)O[Si](C)(C)C AMTWCFIAVKBGOD-UHFFFAOYSA-N 0.000 claims description 12
229940083037 simethicone Drugs 0.000 claims description 12
230000002209 hydrophobic effect Effects 0.000 claims description 10
HWPKGOGLCKPRLZ-UHFFFAOYSA-M monosodium citrate Chemical compound [Na+].OC(=O)CC(O)(C([O-])=O)CC(O)=O HWPKGOGLCKPRLZ-UHFFFAOYSA-M 0.000 claims description 9
235000003599 food sweetener Nutrition 0.000 claims description 8
235000018342 monosodium citrate Nutrition 0.000 claims description 8
239000002524 monosodium citrate Substances 0.000 claims description 8
239000001267 polyvinylpyrrolidone Substances 0.000 claims description 8
235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 8
239000003765 sweetening agent Substances 0.000 claims description 8
CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 7
229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 7
239000005913 Maltodextrin Substances 0.000 claims description 6
229920002774 Maltodextrin Polymers 0.000 claims description 6
230000003254 anti-foaming effect Effects 0.000 claims description 6
235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 claims description 6
229940035034 maltodextrin Drugs 0.000 claims description 6
239000002904 solvent Substances 0.000 claims description 6
BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 5
BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 5
239000007864 aqueous solution Substances 0.000 claims description 5
229910000019 calcium carbonate Inorganic materials 0.000 claims description 5
239000001630 malic acid Substances 0.000 claims description 5
235000011090 malic acid Nutrition 0.000 claims description 5
239000000843 powder Substances 0.000 claims description 5
230000008569 process Effects 0.000 claims description 5
150000003839 salts Chemical class 0.000 claims description 5
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 4
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 4
229910002092 carbon dioxide Inorganic materials 0.000 claims description 4
239000007795 chemical reaction product Substances 0.000 claims description 4
238000002425 crystallisation Methods 0.000 claims description 4
230000008025 crystallization Effects 0.000 claims description 4
239000000796 flavoring agent Substances 0.000 claims description 4
239000008101 lactose Substances 0.000 claims description 4
229960001520 ranitidine hydrochloride Drugs 0.000 claims description 4
GGWBHVILAJZWKJ-KJEVSKRMSA-N ranitidine hydrochloride Chemical compound [H+].[Cl-].[O-][N+](=O)\C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 GGWBHVILAJZWKJ-KJEVSKRMSA-N 0.000 claims description 4
238000009736 wetting Methods 0.000 claims description 4
229940122957 Histamine H2 receptor antagonist Drugs 0.000 claims description 3
239000000872 buffer Substances 0.000 claims description 3
238000010438 heat treatment Methods 0.000 claims description 3
238000004519 manufacturing process Methods 0.000 claims description 3
238000002161 passivation Methods 0.000 claims description 3
229920000642 polymer Polymers 0.000 claims description 3
ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims description 2
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 2
239000002671 adjuvant Substances 0.000 claims description 2
ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 claims description 2
238000001704 evaporation Methods 0.000 claims description 2
235000013355 food flavoring agent Nutrition 0.000 claims description 2
FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 claims description 2
229910052938 sodium sulfate Inorganic materials 0.000 claims description 2
235000011152 sodium sulphate Nutrition 0.000 claims description 2
238000012360 testing method Methods 0.000 claims description 2
229910052783 alkali metal Inorganic materials 0.000 claims 4
150000001447 alkali salts Chemical class 0.000 claims 4
239000010410 layer Substances 0.000 claims 4
239000000375 suspending agent Substances 0.000 claims 4
229910052784 alkaline earth metal Inorganic materials 0.000 claims 3
CDOUZKKFHVEKRI-UHFFFAOYSA-N 3-bromo-n-[(prop-2-enoylamino)methyl]propanamide Chemical compound BrCCC(=O)NCNC(=O)C=C CDOUZKKFHVEKRI-UHFFFAOYSA-N 0.000 claims 2
150000001342 alkaline earth metals Chemical class 0.000 claims 2
239000012928 buffer substance Substances 0.000 claims 2
239000001569 carbon dioxide Substances 0.000 claims 2
229940008099 dimethicone Drugs 0.000 claims 2
235000013870 dimethyl polysiloxane Nutrition 0.000 claims 2
239000004205 dimethyl polysiloxane Substances 0.000 claims 2
239000002798 polar solvent Substances 0.000 claims 2
229920000435 poly(dimethylsiloxane) Polymers 0.000 claims 2
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 1
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims 1
229910000288 alkali metal carbonate Inorganic materials 0.000 claims 1
150000008041 alkali metal carbonates Chemical class 0.000 claims 1
150000001340 alkali metals Chemical class 0.000 claims 1
239000007900 aqueous suspension Substances 0.000 claims 1
235000010323 ascorbic acid Nutrition 0.000 claims 1
229960005070 ascorbic acid Drugs 0.000 claims 1
239000011668 ascorbic acid Substances 0.000 claims 1
230000000881 depressing effect Effects 0.000 claims 1
239000011874 heated mixture Substances 0.000 claims 1
238000003825 pressing Methods 0.000 claims 1
235000019333 sodium laurylsulphate Nutrition 0.000 claims 1
239000002344 surface layer Substances 0.000 claims 1
229940069428 antacid Drugs 0.000 abstract description 4
239000003159 antacid agent Substances 0.000 abstract description 4
230000001458 anti-acid effect Effects 0.000 abstract description 4
238000004090 dissolution Methods 0.000 description 19
238000003756 stirring Methods 0.000 description 18
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 15
ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 13
230000000694 effects Effects 0.000 description 11
239000000605 aspartame Substances 0.000 description 8
229960003438 aspartame Drugs 0.000 description 8
239000006260 foam Substances 0.000 description 8
108010011485 Aspartame Proteins 0.000 description 7
235000010357 aspartame Nutrition 0.000 description 7
IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 7
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
229910002012 Aerosil® Inorganic materials 0.000 description 5
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 5
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 5
239000011734 sodium Substances 0.000 description 5
229910052708 sodium Inorganic materials 0.000 description 5
UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 4
229960000878 docusate sodium Drugs 0.000 description 4
239000000945 filler Substances 0.000 description 4
APSBXTVYXVQYAB-UHFFFAOYSA-M sodium docusate Chemical compound [Na+].CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC APSBXTVYXVQYAB-UHFFFAOYSA-M 0.000 description 4
ILJOYZVVZZFIKA-UHFFFAOYSA-M sodium;1,1-dioxo-1,2-benzothiazol-3-olate;hydrate Chemical compound O.[Na+].C1=CC=C2C(=O)[N-]S(=O)(=O)C2=C1 ILJOYZVVZZFIKA-UHFFFAOYSA-M 0.000 description 4
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
230000015572 biosynthetic process Effects 0.000 description 3
150000004649 carbonic acid derivatives Chemical class 0.000 description 3
239000003795 chemical substances by application Substances 0.000 description 3
239000011521 glass Substances 0.000 description 3
239000001509 sodium citrate Substances 0.000 description 3
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 3
235000011083 sodium citrates Nutrition 0.000 description 3
235000000346 sugar Nutrition 0.000 description 3
238000009827 uniform distribution Methods 0.000 description 3
PXRKCOCTEMYUEG-UHFFFAOYSA-N 5-aminoisoindole-1,3-dione Chemical compound NC1=CC=C2C(=O)NC(=O)C2=C1 PXRKCOCTEMYUEG-UHFFFAOYSA-N 0.000 description 2
235000005979 Citrus limon Nutrition 0.000 description 2
UDIPTWFVPPPURJ-UHFFFAOYSA-M Cyclamate Chemical compound [Na+].[O-]S(=O)(=O)NC1CCCCC1 UDIPTWFVPPPURJ-UHFFFAOYSA-M 0.000 description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 2
239000002585 base Substances 0.000 description 2
239000007910 chewable tablet Substances 0.000 description 2
229940068682 chewable tablet Drugs 0.000 description 2
239000000625 cyclamic acid and its Na and Ca salt Substances 0.000 description 2
238000009826 distribution Methods 0.000 description 2
235000019634 flavors Nutrition 0.000 description 2
238000005187 foaming Methods 0.000 description 2
238000005469 granulation Methods 0.000 description 2
230000003179 granulation Effects 0.000 description 2
239000004615 ingredient Substances 0.000 description 2
238000006386 neutralization reaction Methods 0.000 description 2
239000000825 pharmaceutical preparation Substances 0.000 description 2
229940085605 saccharin sodium Drugs 0.000 description 2
229960001462 sodium cyclamate Drugs 0.000 description 2
239000004094 surface-active agent Substances 0.000 description 2
239000000725 suspension Substances 0.000 description 2
239000011975 tartaric acid Substances 0.000 description 2
235000002906 tartaric acid Nutrition 0.000 description 2
238000001291 vacuum drying Methods 0.000 description 2
229930003231 vitamin Natural products 0.000 description 2
239000011782 vitamin Substances 0.000 description 2
235000013343 vitamin Nutrition 0.000 description 2
229940088594 vitamin Drugs 0.000 description 2
FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 1
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
244000248349 Citrus limon Species 0.000 description 1
244000131522 Citrus pyriformis Species 0.000 description 1
ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
PHOQVHQSTUBQQK-SQOUGZDYSA-N D-glucono-1,5-lactone Chemical compound OC[C@H]1OC(=O)[C@H](O)[C@@H](O)[C@@H]1O PHOQVHQSTUBQQK-SQOUGZDYSA-N 0.000 description 1
239000004375 Dextrin Substances 0.000 description 1
229920001353 Dextrin Polymers 0.000 description 1
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
229930091371 Fructose Natural products 0.000 description 1
RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
239000005715 Fructose Substances 0.000 description 1
RGHNJXZEOKUKBD-SQOUGZDYSA-N Gluconic acid Natural products OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
206010024769 Local reaction Diseases 0.000 description 1
VMXUWOKSQNHOCA-UHFFFAOYSA-N N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine Chemical compound [O-][N+](=O)C=C(NC)NCCSCC1=CC=C(CN(C)C)O1 VMXUWOKSQNHOCA-UHFFFAOYSA-N 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
229930003268 Vitamin C Natural products 0.000 description 1
TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
239000004480 active ingredient Substances 0.000 description 1
239000000853 adhesive Substances 0.000 description 1
230000001070 adhesive effect Effects 0.000 description 1
230000001476 alcoholic effect Effects 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
238000004873 anchoring Methods 0.000 description 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
235000013361 beverage Nutrition 0.000 description 1
235000019658 bitter taste Nutrition 0.000 description 1
239000007853 buffer solution Substances 0.000 description 1
230000003139 buffering effect Effects 0.000 description 1
230000009172 bursting Effects 0.000 description 1
239000011575 calcium Substances 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
235000014633 carbohydrates Nutrition 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
239000008112 carboxymethyl-cellulose Substances 0.000 description 1
150000001860 citric acid derivatives Chemical class 0.000 description 1
VNFPBHJOKIVQEB-UHFFFAOYSA-N clotrimazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)(C=1C=CC=CC=1)C1=CC=CC=C1 VNFPBHJOKIVQEB-UHFFFAOYSA-N 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
239000002274 desiccant Substances 0.000 description 1
235000019425 dextrin Nutrition 0.000 description 1
235000013681 dietary sucrose Nutrition 0.000 description 1
238000010981 drying operation Methods 0.000 description 1
230000008020 evaporation Effects 0.000 description 1
230000001747 exhibiting effect Effects 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
239000000174 gluconic acid Substances 0.000 description 1
235000012208 gluconic acid Nutrition 0.000 description 1
239000008103 glucose Substances 0.000 description 1
239000003485 histamine H2 receptor antagonist Substances 0.000 description 1
238000010348 incorporation Methods 0.000 description 1
230000003993 interaction Effects 0.000 description 1
230000002452 interceptive effect Effects 0.000 description 1
239000007937 lozenge Substances 0.000 description 1
238000012423 maintenance Methods 0.000 description 1
239000000463 material Substances 0.000 description 1
238000005259 measurement Methods 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
150000004682 monohydrates Chemical class 0.000 description 1
230000003647 oxidation Effects 0.000 description 1
238000007254 oxidation reaction Methods 0.000 description 1
WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 1
239000002304 perfume Substances 0.000 description 1
229920006316 polyvinylpyrrolidine Polymers 0.000 description 1
238000012545 processing Methods 0.000 description 1
239000000376 reactant Substances 0.000 description 1
230000009257 reactivity Effects 0.000 description 1
238000001953 recrystallisation Methods 0.000 description 1
230000009467 reduction Effects 0.000 description 1
235000019613 sensory perceptions of taste Nutrition 0.000 description 1
238000003860 storage Methods 0.000 description 1
229960004793 sucrose Drugs 0.000 description 1
238000009492 tablet coating Methods 0.000 description 1
239000002700 tablet coating Substances 0.000 description 1
230000035923 taste sensation Effects 0.000 description 1
238000004448 titration Methods 0.000 description 1
238000009489 vacuum treatment Methods 0.000 description 1
235000019154 vitamin C Nutrition 0.000 description 1
239000011718 vitamin C Substances 0.000 description 1
238000005303 weighing Methods 0.000 description 1
239000000811 xylitol Substances 0.000 description 1
235000010447 xylitol Nutrition 0.000 description 1
HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
229960002675 xylitol Drugs 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent

Landscapes

Health & Medical Sciences (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

CA002183952A 1994-03-01 1995-02-23 Granular product or tablet containing an effervescent system and an active pharmaceutical substance, as well as a method for its preparation Expired - Fee Related CA2183952C (en)

Applications Claiming Priority (7)

Application Number	Priority Date	Filing Date	Title
DEP4406641.4		1994-03-01
DE4406641		1994-03-01
CH87394		1994-03-23
CH873/94-6		1994-03-23
EP94203112.1		1994-10-26
EP94203112A EP0670160B1 (en)	1994-03-01	1994-10-26	Granular product or tablet containing an effervescent system and an active pharmaceutical substance, as well as a method for its preparation
PCT/EP1995/000650 WO1995023594A1 (en)	1994-03-01	1995-02-23	Granular product or tablet containing an effervescent system and an active pharmaceutical substance, as well as a method for its preparation

Publications (2)

Publication Number	Publication Date
CA2183952A1 CA2183952A1 (en)	1995-09-08
CA2183952C true CA2183952C (en)	2007-01-16

Family

ID=27172490

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002183952A Expired - Fee Related CA2183952C (en)	1994-03-01	1995-02-23	Granular product or tablet containing an effervescent system and an active pharmaceutical substance, as well as a method for its preparation

Country Status (15)

Country	Link
JP (1)	JPH09509669A (pl)
CN (1)	CN1213739C (pl)
AU (1)	AU681256B2 (pl)
BR (1)	BR9506964A (pl)
CA (1)	CA2183952C (pl)
CZ (1)	CZ291710B6 (pl)
DE (1)	DE670160T1 (pl)
FI (1)	FI118033B (pl)
HU (1)	HU228147B1 (pl)
NO (1)	NO315308B1 (pl)
NZ (1)	NZ281228A (pl)
PL (1)	PL181714B1 (pl)
RU (1)	RU2153331C2 (pl)
TW (1)	TW403658B (pl)
WO (1)	WO1995023594A1 (pl)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5840737A (en)	1996-01-04	1998-11-24	The Curators Of The University Of Missouri	Omeprazole solution and method for using same
US6489346B1 (en)	1996-01-04	2002-12-03	The Curators Of The University Of Missouri	Substituted benzimidazole dosage forms and method of using same
US20030070584A1 (en)	2001-05-15	2003-04-17	Cynthia Gulian	Dip coating compositions containing cellulose ethers
US8309118B2 (en)	2001-09-28	2012-11-13	Mcneil-Ppc, Inc.	Film forming compositions containing sucralose
DE10224607B4 (de) *	2002-06-04	2008-03-13	Lts Lohmann Therapie-Systeme Ag	Filmförmige, zerfallsfähige Zubereitungen zur Wirkstofffreisetzung und Verfahren zu deren Herstellung
US7429619B2 (en)	2002-08-02	2008-09-30	Mcneil Consumer Healthcare	Polyacrylic film forming compositions
WO2004050068A1 (en)	2002-11-29	2004-06-17	Janssen Pharmaceutica N.V.	Pharmaceutical compositions comprising a basic respectively acidic drug compound, a surfactant and a physiologically tolerable water-soluble acid respectively base
US8993599B2 (en)	2003-07-18	2015-03-31	Santarus, Inc.	Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8906940B2 (en)	2004-05-25	2014-12-09	Santarus, Inc.	Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
JPWO2006059716A1 (ja) *	2004-12-03	2008-06-05	武田薬品工業株式会社	固形製剤
BR112012015923A2 (pt)	2010-02-26	2020-09-08	Toray Industries, Inc.	"preparação sólida revestida"
MX374994B (es)	2011-12-09	2025-03-06	Merck Patent Gmbh	Carbonato de sodio anhidro que tiene un bajo contenido de poros.
WO2014065890A1 (en) *	2012-10-25	2014-05-01	Otc Nutrition Llc	Fast dissolving solid calcium mineral supplement compositions and process of making
NZ708741A (en)	2012-12-19	2019-11-29	Bayer Animal Health Gmbh	Tablets with improved acceptance and good storage stability
CN105670003A (zh) *	2014-11-21	2016-06-15	常州坤宇环保科技有限公司	高吸水树脂防结块剂
EP3318135A1 (en) *	2016-11-03	2018-05-09	Perfetti Van Melle S.p.A.	Effervescent candy material, a process for its preparation and products made therefrom
MX2022004643A (es) *	2019-10-17	2022-07-27	Isp Investments Llc	Una composición de excipiente coprocesado efervescente estable y un proceso de preparación de la misma.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU1039170A (en) *	1969-02-24	1971-07-22	Abbott Laboratories	Tableting medium
US4704269A (en) *	1985-06-11	1987-11-03	Hudson Pharmaceutical Corporation	Effervescent antacid and analgesic compositions
CA2023493C (en) *	1989-08-31	2000-01-04	Masami Moroi	Composition for foaming preparation
CA2112663C (en) *	1991-07-01	2002-04-23	Thomas Gergely	Effervescent systems using reaction doping agents

1994
- 1994-10-26 DE DE0670160T patent/DE670160T1/de active Pending
1995
- 1995-02-23 BR BR9506964A patent/BR9506964A/pt not_active Application Discontinuation
- 1995-02-23 CN CN95191882.6A patent/CN1213739C/zh not_active Expired - Fee Related
- 1995-02-23 AU AU18114/95A patent/AU681256B2/en not_active Ceased
- 1995-02-23 JP JP7522671A patent/JPH09509669A/ja active Pending
- 1995-02-23 CZ CZ19962519A patent/CZ291710B6/cs not_active IP Right Cessation
- 1995-02-23 HU HU9602380A patent/HU228147B1/hu not_active IP Right Cessation
- 1995-02-23 RU RU96120083/14A patent/RU2153331C2/ru not_active IP Right Cessation
- 1995-02-23 WO PCT/EP1995/000650 patent/WO1995023594A1/en not_active Ceased
- 1995-02-23 NZ NZ281228A patent/NZ281228A/en unknown
- 1995-02-23 CA CA002183952A patent/CA2183952C/en not_active Expired - Fee Related
- 1995-03-01 TW TW084101871A patent/TW403658B/zh not_active IP Right Cessation
1996
- 1996-08-22 PL PL95316113A patent/PL181714B1/pl unknown
- 1996-08-28 NO NO19963588A patent/NO315308B1/no not_active IP Right Cessation
- 1996-08-30 FI FI963385A patent/FI118033B/fi not_active IP Right Cessation

Also Published As

Publication number	Publication date
PL316113A1 (en)	1996-12-23
NZ281228A (en)	1997-06-24
JPH09509669A (ja)	1997-09-30
RU2153331C2 (ru)	2000-07-27
PL181714B1 (en)	2001-09-28
FI963385L (fi)	1996-10-30
HU228147B1 (en)	2012-12-28
CZ291710B6 (cs)	2003-05-14
CZ251996A3 (en)	1997-01-15
FI963385A0 (fi)	1996-08-30
HU9602380D0 (en)	1996-10-28
AU681256B2 (en)	1997-08-21
CA2183952A1 (en)	1995-09-08
NO963588D0 (no)	1996-08-28
AU1811495A (en)	1995-09-18
NO315308B1 (no)	2003-08-18
TW403658B (en)	2000-09-01
BR9506964A (pt)	1997-09-09
HUT75677A (en)	1997-05-28
NO963588L (no)	1996-10-31
CN1213739C (zh)	2005-08-10
DE670160T1 (de)	1996-03-14
WO1995023594A1 (en)	1995-09-08
CN1142182A (zh)	1997-02-05
FI118033B (fi)	2007-06-15

Legal Events

Date	Code	Title	Description
2002-01-09	EEER	Examination request
2008-02-25	MKLA	Lapsed

Publication	Publication Date	Title
EP0670160B1 (en)	1999-07-14	Granular product or tablet containing an effervescent system and an active pharmaceutical substance, as well as a method for its preparation
US5792473A (en)	1998-08-11	Granular product or tablet containing an effervescent system and an active pharmaceutical substance, as well as a method for its preparation
CA2183952C (en)	2007-01-16	Granular product or tablet containing an effervescent system and an active pharmaceutical substance, as well as a method for its preparation
US5415870A (en)	1995-05-16	Effervescent systems using reaction doping agents
EP0501985B1 (en)	1994-01-26	Uncoated pharmaceutical reaction tablet
KR100767928B1 (ko)	2007-10-17	활성 성분의 맛이 차폐되고 활성 성분이 즉시 방출되는 코팅된 과립의 제조 방법
US20040171669A1 (en)	2004-09-02	Coated granules based on angiotensin-converting enzyme inhibitor
BG65043B1 (bg)	2007-01-31	Ефервесцентни форми
AU703310B2 (en)	1999-03-25	A rapidly disintegrating medicinal form of tramadol or a tramadol salt
US5869095A (en)	1999-02-09	Chewable tablet with an effervescent action
IL142788A (en)	2006-08-01	Fast disintegrating tablet
JP2005527508A (ja)	2005-09-15	経口デリバリー用急速溶融多粒子製剤
PL200672B1 (pl)	2009-01-30	Farmaceutyczna postać dawkowania szybko rozpadająca się w ustach i sposób jej wytwarzania
CA2551662A1 (en)	2005-07-14	Multiparticulate formulations for oral delivery
WO2004089343A1 (en)	2004-10-21	Water soluble tablets
US4352821A (en)	1982-10-05	Sweet tableting agent
CA2218370C (en)	2006-10-03	Chewable tablet with effervescent action
JP4719899B2 (ja)	2011-07-06	口腔内速崩壊性錠剤