CA2185246A1 - Compositions pharmaceutique de derives d'indene permettant une regulation de l'apoptose - Google Patents
Compositions pharmaceutique de derives d'indene permettant une regulation de l'apoptoseInfo
- Publication number
- CA2185246A1 CA2185246A1 CA 2185246 CA2185246A CA2185246A1 CA 2185246 A1 CA2185246 A1 CA 2185246A1 CA 2185246 CA2185246 CA 2185246 CA 2185246 A CA2185246 A CA 2185246A CA 2185246 A1 CA2185246 A1 CA 2185246A1
- Authority
- CA
- Canada
- Prior art keywords
- dihydro
- treating
- indene
- pharmaceutical composition
- active ingredient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 230000000607 poisoning effect Effects 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229940093429 polyethylene glycol 6000 Drugs 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- NNFCIKHAZHQZJG-UHFFFAOYSA-N potassium cyanide Chemical compound [K+].N#[C-] NNFCIKHAZHQZJG-UHFFFAOYSA-N 0.000 description 1
- 229940093916 potassium phosphate Drugs 0.000 description 1
- 229910000160 potassium phosphate Inorganic materials 0.000 description 1
- 235000011009 potassium phosphates Nutrition 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 201000008171 proliferative glomerulonephritis Diseases 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 210000004129 prosencephalon Anatomy 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 201000004240 prostatic hypertrophy Diseases 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
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- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 230000028043 self proteolysis Effects 0.000 description 1
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- 238000000926 separation method Methods 0.000 description 1
- 239000004208 shellac Substances 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 235000020374 simple syrup Nutrition 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 229960004274 stearic acid Drugs 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000001973 tert-pentyl group Chemical group [H]C([H])([H])C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 206010043554 thrombocytopenia Diseases 0.000 description 1
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- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Cette invention présente une composition pharmaceutique destinée à réguler l'apoptose, contenant au moins un ingrédient actif choisi dans le groupe constitué de dérivés de 2,3-dihydro-1H-indène, représentés par la formule générale (I) (dans laquelle R?1¿, R?2¿, R?3¿, et R?4¿ sont, chacun, identiques ou différents et sont des groupes alkyle inférieur et R?5¿ un groupe alcoxy inférieur, <u>A</u> étant un groupe alkylène inférieur) ainsi que les sels qui en sont issus. Cette invention présente également des méthodes de traitement et de prévention de diverses maladies par la régulation de l'apoptose, du fait de l'utilisation de ladite composition pharmaceutique.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7/2490 | 1995-01-11 | ||
| JP249095 | 1995-01-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2185246A1 true CA2185246A1 (fr) | 1996-07-18 |
Family
ID=11530812
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2185246 Abandoned CA2185246A1 (fr) | 1995-01-11 | 1995-12-15 | Compositions pharmaceutique de derives d'indene permettant une regulation de l'apoptose |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0749311A1 (fr) |
| CN (1) | CN1143322A (fr) |
| AR (1) | AR001786A1 (fr) |
| AU (1) | AU4188896A (fr) |
| CA (1) | CA2185246A1 (fr) |
| MX (1) | MX9603868A (fr) |
| WO (1) | WO1996021449A1 (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2763847B1 (fr) | 1997-05-28 | 2003-06-06 | Sanofi Sa | Utilisation de tetrahydropyridines 4-substituees pour fabriquer des medicaments agissant sur le tgf-beta-1 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03112928A (ja) * | 1989-09-25 | 1991-05-14 | Otsuka Pharmaceut Co Ltd | 吸収性が改善された製剤組成物 |
| CA2090876A1 (fr) * | 1991-07-03 | 1993-01-04 | Otsuka Pharmaceutical Co., Ltd. | Composition regulatrice d'apoptose |
-
1995
- 1995-12-15 AU AU41888/96A patent/AU4188896A/en not_active Abandoned
- 1995-12-15 EP EP95940447A patent/EP0749311A1/fr not_active Withdrawn
- 1995-12-15 CA CA 2185246 patent/CA2185246A1/fr not_active Abandoned
- 1995-12-15 WO PCT/JP1995/002578 patent/WO1996021449A1/fr not_active Ceased
- 1995-12-15 CN CN 95192015 patent/CN1143322A/zh active Pending
- 1995-12-15 MX MX9603868A patent/MX9603868A/es unknown
-
1996
- 1996-01-04 AR AR33493196A patent/AR001786A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO1996021449A1 (fr) | 1996-07-18 |
| CN1143322A (zh) | 1997-02-19 |
| MX9603868A (es) | 1997-03-29 |
| AU4188896A (en) | 1996-07-31 |
| AR001786A1 (es) | 1997-12-10 |
| EP0749311A1 (fr) | 1996-12-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Dead |