CA2186526C - Procede et produit de regulation de la sensibilite des cellules a des signaux externes - Google Patents
Procede et produit de regulation de la sensibilite des cellules a des signaux externesInfo
- Publication number
- CA2186526C CA2186526C CA002186526A CA2186526A CA2186526C CA 2186526 C CA2186526 C CA 2186526C CA 002186526 A CA002186526 A CA 002186526A CA 2186526 A CA2186526 A CA 2186526A CA 2186526 C CA2186526 C CA 2186526C
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- Prior art keywords
- mekk
- protein
- leu
- glu
- ser
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Container Filling Or Packaging Operations (AREA)
Abstract
L'invention concerne des protéines MEKK isolées, des molécules d'acides nucléiques ayant des séquences qui codent de telles protéines, ainsi que des anticorpss dressés contre de telles protéines. La présente invention concerne également des procédés d'utilisation de telles protéines pour la régulation de la transduction de signaux dans une cellule. La présente invention concerne également des compositions thérapeutiques comprenant ces protéines ou des molécules d'acide nucléique qui codent ces protéines ainsi que leur utilisation pour le traitement d'animaux présentant des problèmes d'ordre médical tel qu'un cancer, une inflammation, des dysfonctionnements neurologiques, des maladies auto-immunes, des réactions allergiques et des maladies hormonales. Lorsque MEKK est exprimée, elle se phosphorylise et active les MEKs y compris MEK-1, MEK-2 et JEK.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| WOPCT/US94/04178 | 1994-04-15 | ||
| PCT/US1994/004178 WO1994024159A1 (fr) | 1993-04-15 | 1994-04-15 | Procede et produit de regulation de la reactivite cellulaire a des signaux externes |
| PCT/US1994/011690 WO1995028421A1 (fr) | 1993-04-15 | 1994-10-14 | Procede et produit de regulation de la sensibilite des cellules a des signaux externes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2186526A1 CA2186526A1 (fr) | 1995-10-26 |
| CA2186526C true CA2186526C (fr) | 1999-12-14 |
Family
ID=22242467
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002186526A Expired - Fee Related CA2186526C (fr) | 1994-04-15 | 1994-10-14 | Procede et produit de regulation de la sensibilite des cellules a des signaux externes |
Country Status (5)
| Country | Link |
|---|---|
| JP (2) | JP3980635B2 (fr) |
| AT (1) | ATE319821T1 (fr) |
| AU (1) | AU703070B2 (fr) |
| CA (1) | CA2186526C (fr) |
| DE (1) | DE69434650T2 (fr) |
-
1994
- 1994-10-14 JP JP52693995A patent/JP3980635B2/ja not_active Expired - Lifetime
- 1994-10-14 AU AU80177/94A patent/AU703070B2/en not_active Ceased
- 1994-10-14 DE DE69434650T patent/DE69434650T2/de not_active Expired - Fee Related
- 1994-10-14 AT AT94931372T patent/ATE319821T1/de not_active IP Right Cessation
- 1994-10-14 CA CA002186526A patent/CA2186526C/fr not_active Expired - Fee Related
-
2005
- 2005-07-25 JP JP2005215113A patent/JP3980609B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2186526A1 (fr) | 1995-10-26 |
| JP2006051026A (ja) | 2006-02-23 |
| ATE319821T1 (de) | 2006-03-15 |
| DE69434650D1 (de) | 2006-05-04 |
| AU8017794A (en) | 1995-11-10 |
| JPH09511906A (ja) | 1997-12-02 |
| AU703070B2 (en) | 1999-03-11 |
| JP3980609B2 (ja) | 2007-09-26 |
| JP3980635B2 (ja) | 2007-09-26 |
| DE69434650T2 (de) | 2006-11-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |