CA2187360A1 - Utilisation d'agents bloquant l'interaction molecule d'adhesion intercellulaire/recepteur dans le traitement d'une infection respiratoire virale - Google Patents

Utilisation d'agents bloquant l'interaction molecule d'adhesion intercellulaire/recepteur dans le traitement d'une infection respiratoire virale

Info

Publication number
CA2187360A1
CA2187360A1 CA002187360A CA2187360A CA2187360A1 CA 2187360 A1 CA2187360 A1 CA 2187360A1 CA 002187360 A CA002187360 A CA 002187360A CA 2187360 A CA2187360 A CA 2187360A CA 2187360 A1 CA2187360 A1 CA 2187360A1
Authority
CA
Canada
Prior art keywords
icam
family
antibody
glycoproteins
agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002187360A
Other languages
English (en)
Inventor
Craig D. Wegner
Ernest L. Raymond
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2187360A1 publication Critical patent/CA2187360A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70525—ICAM molecules, e.g. CD50, CD54, CD102
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70546—Integrin superfamily
    • C07K14/70553—Integrin beta2-subunit-containing molecules, e.g. CD11, CD18
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2821—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2845—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne l'utilisation de molécules d'adhésion intercellulaire (ICAM-1), leurs dérivés fonctionnels, et des molécules qui se lient à eux, dans des procédés destinés à accroître les échanges gazeux dans les poumons d'un patient souffrant d'une infection respiratoire virale.
CA002187360A 1994-04-12 1995-04-12 Utilisation d'agents bloquant l'interaction molecule d'adhesion intercellulaire/recepteur dans le traitement d'une infection respiratoire virale Abandoned CA2187360A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22599794A 1994-04-12 1994-04-12
US08/225,997 1994-04-12

Publications (1)

Publication Number Publication Date
CA2187360A1 true CA2187360A1 (fr) 1995-10-19

Family

ID=22847133

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002187360A Abandoned CA2187360A1 (fr) 1994-04-12 1995-04-12 Utilisation d'agents bloquant l'interaction molecule d'adhesion intercellulaire/recepteur dans le traitement d'une infection respiratoire virale

Country Status (4)

Country Link
EP (1) EP0757697A4 (fr)
JP (1) JPH09512252A (fr)
CA (1) CA2187360A1 (fr)
WO (1) WO1995027736A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0362531B1 (fr) 1988-09-01 1999-11-10 Bayer Corporation Protéine du récepteur du rhinovirus humain, qui inhibe le caractère infectieux du virus
US6130202A (en) * 1990-07-20 2000-10-10 Bayer Corporation Antiviral methods
US5817515A (en) * 1993-12-23 1998-10-06 Icos Corporation Human B2 integrin alpha subunit antibodies
US6391452B1 (en) 1997-07-18 2002-05-21 Bayer Corporation Compositions for nasal drug delivery, methods of making same, and methods of removing residual solvent from pharmaceutical preparations
JP2007535654A (ja) * 2003-04-23 2007-12-06 ハンサ メディカル アクチボラゲット 抗連鎖球菌物質の確認方法、及び連鎖球菌感染症治療のためのその使用
US12447166B2 (en) * 2016-02-25 2025-10-21 Applied Biological Laboratories, Inc. Compositions and methods for protecting against airborne pathogens and irritants
US12594285B2 (en) 2016-02-25 2026-04-07 Applied Biological Laboratories, Inc. Compositions and methods for protecting against airborne pathogens and irritants
EP3419629A4 (fr) 2016-02-25 2019-10-30 Applied Biological Laboratories, Inc. Compositions et procédés de protection contre des agents pathogènes et des substances irritantes aériens

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE128727T1 (de) * 1987-05-04 1995-10-15 Dana Farber Cancer Inst Inc Interzellulare adhäsions-moleküle und deren bindungsliganden.
ATE114972T1 (de) * 1987-11-02 1994-12-15 Baylor College Medicine Verwendung von icam-1 oder ihre funktionelle derivate zur behandlung unspezifischer entzündungen.
US5235049A (en) * 1989-01-24 1993-08-10 Molecular Therapeutics, Inc. Nucleic acid sequences encoding a soluble molecule (SICAM-1) related to but distinct from ICAM-1
DK0745852T3 (da) * 1989-03-16 2002-10-14 Blood Res Center Anvendelse af funktionelle derivater af intercellulær adhæsion-molekylet ICAM-1 i antiviral terapi
WO1993006842A1 (fr) * 1991-10-02 1993-04-15 Boehringer Ingelheim Pharmaceuticals, Inc. Utilisation de molecules d'adhesion intercellulaire et de leurs ligands de liaison dans le traitement de l'asthme

Also Published As

Publication number Publication date
EP0757697A4 (fr) 2000-05-17
JPH09512252A (ja) 1997-12-09
WO1995027736A1 (fr) 1995-10-19
EP0757697A1 (fr) 1997-02-12

Similar Documents

Publication Publication Date Title
Pretolani et al. Antibody to very late activation antigen 4 prevents antigen-induced bronchial hyperreactivity and cellular infiltration in the guinea pig airways.
US5324510A (en) Use of antibodies to intercellular adhesion molecule-1 (ICAM-1) in the treatment of asthma
DE69129743T2 (de) Humanisierte chimäre anti-"icam-1" antikörper, herstellungsverfahren und verwendung
Bochner et al. Adhesion of human basophils, eosinophils, and neutrophils to interleukin 1-activated human vascular endothelial cells: contributions of endothelial cell adhesion molecules.
EP0387701B1 (fr) Utilisation des molécules d'adhésion intercellulaire et leurs ligands de liaison dans le traitement de l'asthme
Schleimer et al. IL-4 induces adherence of human eosinophils and basophils but not neutrophils to endothelium. Association with expression of VCAM-1
AU674302B2 (en) Treatment for inflammatory bowel disease
DE69835766T2 (de) Neues peptid, apoep1.b, zusammensetzungen und verwendungen davon
DK175491B1 (da) Anvendelse af ICAM-1 og dets funktionelle derivater til behandling af ikke-specifik inflammation
EP0626861B2 (fr) Traitement de l'asthme
WO1990013316A1 (fr) Dissemination de cellules infectees par l'hiv-1
WO1993024614A1 (fr) Anticorps avec specificite pour de multiples molecules d'adhesion
EP2465873A1 (fr) Eosinophilic leukocyte en tant que cible thérapeutique
Root Leukocyte adhesion proteins: their role in neutrophil function
EP0757697A1 (fr) Utilisation d'agents bloquant l'interaction molecule d'adhesion intercellulaire/recepteur dans le traitement d'une infection respiratoire virale
Laffon et al. Very late activation antigen on synovial fluid T cells from patients with rheumatoid arthritis and other rheumatic diseases
US20090304681A1 (en) Methods for the treatment and prevention of infection using anti-selectin agents
Grigg et al. Induction of intercellular adhesion molecule-1 by lipopolysaccharide in canine alveolar macrophages
WO1993006842A1 (fr) Utilisation de molecules d'adhesion intercellulaire et de leurs ligands de liaison dans le traitement de l'asthme
AU663332B2 (en) Use of endothelial-leukocyte adhesion molecule-1 and antibodies thereto in the treatment of asthma
AU655459B2 (en) Method for inhibiting pulmonary oxygen toxicity
Gundel et al. Adhesion molecules in a primate model of allergic asthma: clinical implications for respiratory care
MXPA96004715A (en) Use of agents that block the molecular interaction / receiver adhesion interaction in the treatment of viral infections respirator
AU665232C (en) Treatment for asthma
e Silva et al. Prevention of Antigen‐Induced Bronchial Hyperreactivity and Airway Inflammation in Sensitized Guinea‐Pigs by Tacrolimus

Legal Events

Date Code Title Description
FZDE Dead