CA2187783C - Dosages et dispositifs de detection de l'atresie des voies biliaires extra-hepatiques - Google Patents
Dosages et dispositifs de detection de l'atresie des voies biliaires extra-hepatiques Download PDFInfo
- Publication number
- CA2187783C CA2187783C CA002187783A CA2187783A CA2187783C CA 2187783 C CA2187783 C CA 2187783C CA 002187783 A CA002187783 A CA 002187783A CA 2187783 A CA2187783 A CA 2187783A CA 2187783 C CA2187783 C CA 2187783C
- Authority
- CA
- Canada
- Prior art keywords
- dipeptidyl peptidase
- test sample
- antibody
- substrate
- dppiv
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 201000005271 biliary atresia Diseases 0.000 title claims abstract description 64
- 208000012479 extrahepatic biliary atresia Diseases 0.000 title claims abstract description 60
- 238000003556 assay Methods 0.000 title claims abstract description 59
- 238000001514 detection method Methods 0.000 title claims abstract description 26
- 238000012360 testing method Methods 0.000 claims abstract description 72
- 101000930822 Giardia intestinalis Dipeptidyl-peptidase 4 Proteins 0.000 claims abstract description 47
- 238000000034 method Methods 0.000 claims abstract description 24
- 238000012216 screening Methods 0.000 claims abstract description 7
- 102000016622 Dipeptidyl Peptidase 4 Human genes 0.000 claims abstract 25
- 239000000758 substrate Substances 0.000 claims description 52
- 239000003153 chemical reaction reagent Substances 0.000 claims description 44
- 238000006243 chemical reaction Methods 0.000 claims description 20
- 210000002700 urine Anatomy 0.000 claims description 19
- 210000002966 serum Anatomy 0.000 claims description 18
- 239000007795 chemical reaction product Substances 0.000 claims description 15
- 102000035195 Peptidases Human genes 0.000 claims description 10
- 108091005804 Peptidases Proteins 0.000 claims description 10
- 239000012530 fluid Substances 0.000 claims description 9
- 239000004365 Protease Substances 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 8
- 235000019419 proteases Nutrition 0.000 claims description 8
- 230000015572 biosynthetic process Effects 0.000 claims description 7
- 239000003593 chromogenic compound Substances 0.000 claims description 7
- 239000007790 solid phase Substances 0.000 claims description 7
- 230000009471 action Effects 0.000 claims description 6
- 150000001413 amino acids Chemical class 0.000 claims description 6
- 239000011148 porous material Substances 0.000 claims description 4
- 230000000977 initiatory effect Effects 0.000 claims description 2
- 235000019833 protease Nutrition 0.000 claims description 2
- 238000011144 upstream manufacturing Methods 0.000 claims description 2
- 230000002596 correlated effect Effects 0.000 claims 5
- 102100025012 Dipeptidyl peptidase 4 Human genes 0.000 description 106
- 101000684208 Homo sapiens Prolyl endopeptidase FAP Proteins 0.000 description 81
- 239000000463 material Substances 0.000 description 31
- 230000000694 effects Effects 0.000 description 28
- 239000012491 analyte Substances 0.000 description 20
- 102100034798 CCAAT/enhancer-binding protein beta Human genes 0.000 description 18
- 102000004190 Enzymes Human genes 0.000 description 18
- 108090000790 Enzymes Proteins 0.000 description 18
- 238000005259 measurement Methods 0.000 description 12
- 230000002485 urinary effect Effects 0.000 description 10
- 238000000159 protein binding assay Methods 0.000 description 9
- 210000004185 liver Anatomy 0.000 description 8
- 210000000013 bile duct Anatomy 0.000 description 7
- 238000009739 binding Methods 0.000 description 7
- 206010023126 Jaundice Diseases 0.000 description 6
- 230000027455 binding Effects 0.000 description 6
- 238000003745 diagnosis Methods 0.000 description 6
- 210000000981 epithelium Anatomy 0.000 description 6
- 230000009870 specific binding Effects 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 206010010317 Congenital absence of bile ducts Diseases 0.000 description 5
- 210000000941 bile Anatomy 0.000 description 5
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 4
- 206010019799 Hepatitis viral Diseases 0.000 description 4
- 239000000427 antigen Substances 0.000 description 4
- 102000036639 antigens Human genes 0.000 description 4
- 108091007433 antigens Proteins 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 238000013399 early diagnosis Methods 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 201000001862 viral hepatitis Diseases 0.000 description 4
- 206010000206 ABO incompatibility Diseases 0.000 description 3
- 102100022749 Aminopeptidase N Human genes 0.000 description 3
- 108010016626 Dipeptides Proteins 0.000 description 3
- 101000757160 Homo sapiens Aminopeptidase N Proteins 0.000 description 3
- 101000908391 Homo sapiens Dipeptidyl peptidase 4 Proteins 0.000 description 3
- 102000002704 Leucyl aminopeptidase Human genes 0.000 description 3
- 108010004098 Leucyl aminopeptidase Proteins 0.000 description 3
- 210000003445 biliary tract Anatomy 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 229920002678 cellulose Polymers 0.000 description 3
- 239000001913 cellulose Substances 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 210000001035 gastrointestinal tract Anatomy 0.000 description 3
- 208000006454 hepatitis Diseases 0.000 description 3
- 231100000283 hepatitis Toxicity 0.000 description 3
- 238000003018 immunoassay Methods 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 210000003734 kidney Anatomy 0.000 description 3
- 238000013508 migration Methods 0.000 description 3
- 230000005012 migration Effects 0.000 description 3
- 230000000750 progressive effect Effects 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 238000001356 surgical procedure Methods 0.000 description 3
- 238000002054 transplantation Methods 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- 108090001008 Avidin Proteins 0.000 description 2
- 208000008439 Biliary Liver Cirrhosis Diseases 0.000 description 2
- 206010004659 Biliary cirrhosis Diseases 0.000 description 2
- 206010023129 Jaundice cholestatic Diseases 0.000 description 2
- 206010067125 Liver injury Diseases 0.000 description 2
- 201000005267 Obstructive Jaundice Diseases 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 230000003872 anastomosis Effects 0.000 description 2
- 210000000741 bile canaliculi Anatomy 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000012875 competitive assay Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 2
- 239000003599 detergent Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000003394 haemopoietic effect Effects 0.000 description 2
- 231100000234 hepatic damage Toxicity 0.000 description 2
- 239000004816 latex Substances 0.000 description 2
- 229920000126 latex Polymers 0.000 description 2
- 239000002502 liposome Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000008818 liver damage Effects 0.000 description 2
- 239000013642 negative control Substances 0.000 description 2
- 229920000620 organic polymer Polymers 0.000 description 2
- 230000036285 pathological change Effects 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 239000011535 reaction buffer Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- 229920000936 Agarose Polymers 0.000 description 1
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
- 102000004400 Aminopeptidases Human genes 0.000 description 1
- 108090000915 Aminopeptidases Proteins 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 201000003883 Cystic fibrosis Diseases 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 238000008789 Direct Bilirubin Methods 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- 208000027472 Galactosemias Diseases 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 208000000857 Hepatic Insufficiency Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- 208000035752 Live birth Diseases 0.000 description 1
- 102000018697 Membrane Proteins Human genes 0.000 description 1
- 108010052285 Membrane Proteins Proteins 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 235000017284 Pometia pinnata Nutrition 0.000 description 1
- 240000007653 Pometia tomentosa Species 0.000 description 1
- 208000035977 Rare disease Diseases 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 230000006044 T cell activation Effects 0.000 description 1
- 238000008050 Total Bilirubin Reagent Methods 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 229920004890 Triton X-100 Polymers 0.000 description 1
- 239000013504 Triton X-100 Substances 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000003613 bile acid Substances 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000013060 biological fluid Substances 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 229910010293 ceramic material Inorganic materials 0.000 description 1
- 208000003167 cholangitis Diseases 0.000 description 1
- 230000007882 cirrhosis Effects 0.000 description 1
- 208000019425 cirrhosis of liver Diseases 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 230000009918 complex formation Effects 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 229960000956 coumarin Drugs 0.000 description 1
- 229940109239 creatinine Drugs 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 238000003748 differential diagnosis Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 230000002183 duodenal effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 210000002603 extrahepatic bile duct Anatomy 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000011152 fibreglass Substances 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 210000005205 gut mucosa Anatomy 0.000 description 1
- 230000002962 histologic effect Effects 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 238000003317 immunochromatography Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 238000002350 laparotomy Methods 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 238000012317 liver biopsy Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 239000013528 metallic particle Substances 0.000 description 1
- 210000000110 microvilli Anatomy 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000013188 needle biopsy Methods 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000000123 paper Substances 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 208000037821 progressive disease Diseases 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000012207 quantitative assay Methods 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000037390 scarring Effects 0.000 description 1
- 238000012206 semi-quantitative assay Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 238000011895 specific detection Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 230000000153 supplemental effect Effects 0.000 description 1
- 238000011477 surgical intervention Methods 0.000 description 1
- 230000001839 systemic circulation Effects 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 210000001578 tight junction Anatomy 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 208000019206 urinary tract infection Diseases 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54386—Analytical elements
- G01N33/54387—Immunochromatographic test strips
- G01N33/54388—Immunochromatographic test strips based on lateral flow
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
- C12Q2337/10—Anilides
- C12Q2337/12—Para-Nitroanilides p-NA
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
La présente invention concerne une gamme de procédés et de dispositifs de dosage destinés à détecter ou à diagnostiquer la présence de l'atrésie des voies biliaires extra-hépatiques. En particulier, lesdits procédés et dispositifs concernent la détection de la dipeptidyle peptidase IV dans un échantillon d'essai comme étant une indication de l'atrésie des voies biliaires extra-hépatiques.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/275,887 US5601986A (en) | 1994-07-14 | 1994-07-14 | Assays and devices for the detection of extrahepatic biliary atresia |
| US08/275,887 | 1994-07-14 | ||
| PCT/US1995/008898 WO1996002667A1 (fr) | 1994-07-14 | 1995-07-13 | Dosages et dispositifs de detection de l'atresie des voies biliaires extra-hepatiques |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2187783A1 CA2187783A1 (fr) | 1996-02-01 |
| CA2187783C true CA2187783C (fr) | 2000-02-08 |
Family
ID=23054238
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002187783A Expired - Fee Related CA2187783C (fr) | 1994-07-14 | 1995-07-13 | Dosages et dispositifs de detection de l'atresie des voies biliaires extra-hepatiques |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5601986A (fr) |
| EP (1) | EP0820522B1 (fr) |
| AT (1) | ATE205884T1 (fr) |
| AU (1) | AU3538195A (fr) |
| CA (1) | CA2187783C (fr) |
| DE (1) | DE69522831T2 (fr) |
| DK (1) | DK0820522T3 (fr) |
| ES (1) | ES2160714T3 (fr) |
| PT (1) | PT820522E (fr) |
| WO (1) | WO1996002667A1 (fr) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020086399A1 (en) * | 1996-02-29 | 2002-07-04 | Fuji Photo Film Co., Ltd. | Method of measurement of protease and thin membranes used for said method |
| US6235493B1 (en) * | 1997-08-06 | 2001-05-22 | The Regents Of The University Of California | Amino acid substituted-cresyl violet, synthetic fluorogenic substrates for the analysis of agents in individual in vivo cells or tissue |
| US20040242568A1 (en) * | 2003-03-25 | 2004-12-02 | Syrrx, Inc. | Dipeptidyl peptidase inhibitors |
| WO2004103993A1 (fr) | 2003-05-14 | 2004-12-02 | Syrrx, Inc. | Inhibiteurs de dipeptidyl peptidase |
| US7678909B1 (en) | 2003-08-13 | 2010-03-16 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| EP1506967B1 (fr) * | 2003-08-13 | 2007-11-21 | Takeda Pharmaceutical Company Limited | Inhibiteurs de dipeptidyl peptidase. |
| US7169926B1 (en) | 2003-08-13 | 2007-01-30 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| EP1699777B1 (fr) * | 2003-09-08 | 2012-12-12 | Takeda Pharmaceutical Company Limited | Inhibiteurs de la dipeptidylpeptidase |
| JP2007513058A (ja) * | 2003-09-08 | 2007-05-24 | 武田薬品工業株式会社 | ジペプチジルぺプチダーゼ阻害剤 |
| US7732446B1 (en) | 2004-03-11 | 2010-06-08 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| MXPA06010571A (es) * | 2004-03-15 | 2007-02-16 | Takeda Pharmaceutical | Inhibidores de dipeptidil peptidasa. |
| US7687638B2 (en) * | 2004-06-04 | 2010-03-30 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
| WO2006019965A2 (fr) | 2004-07-16 | 2006-02-23 | Takeda San Diego, Inc. | Inhibiteurs de la dipeptidyl peptidase |
| US20060019406A1 (en) * | 2004-07-23 | 2006-01-26 | Ning Wei | Lateral flow device for the detection of large pathogens |
| US20060068500A1 (en) * | 2004-09-28 | 2006-03-30 | Kimberly-Clark Worldwide, Inc. | Detecting yeast infections using a lateral flow assay |
| EP1828192B1 (fr) * | 2004-12-21 | 2014-12-03 | Takeda Pharmaceutical Company Limited | Inhibiteurs de dipeptidyle peptidase |
| US8506934B2 (en) | 2005-04-29 | 2013-08-13 | Robert I. Henkin | Methods for detection of biological substances |
| WO2007033265A1 (fr) * | 2005-09-14 | 2007-03-22 | Takeda Pharmaceutical Company Limited | Inhibiteurs de dipeptidyl peptidase utilises pour traiter le diabete |
| CA2622608C (fr) * | 2005-09-14 | 2014-08-19 | Takeda Pharmaceutical Company Limited | Administration d'inhibiteurs de dipeptidyl peptidase |
| ME02005B (fr) | 2005-09-14 | 2012-08-31 | Takeda Pharmaceuticals Co | Inhibiteurs de la dipeptidyl peptidase permettant de traiter le diabete |
| CN101360723A (zh) * | 2005-09-16 | 2009-02-04 | 武田药品工业株式会社 | 制备嘧啶二酮衍生物的方法 |
| TW200745080A (en) * | 2005-09-16 | 2007-12-16 | Takeda Pharmaceuticals Co | Polymorphs of tartrate salt of 2-[2-(3-(R)-amino-piperidin-1-yl)-5-fluoro-6-oxo-6H-pyrimidin-1-ylmethyl]-benzonitrile and methods of use therefor |
| TW200745079A (en) * | 2005-09-16 | 2007-12-16 | Takeda Pharmaceuticals Co | Polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile and methods of use therefor |
| GB2435512A (en) * | 2006-02-23 | 2007-08-29 | Mologic Ltd | A binding assay and assay device |
| GB2435511A (en) * | 2006-02-23 | 2007-08-29 | Mologic Ltd | Protease detection |
| GB2435510A (en) | 2006-02-23 | 2007-08-29 | Mologic Ltd | Enzyme detection product and methods |
| WO2007112347A1 (fr) | 2006-03-28 | 2007-10-04 | Takeda Pharmaceutical Company Limited | Inhibiteurs de la dipeptidyl peptidase |
| US20100029941A1 (en) * | 2006-03-28 | 2010-02-04 | Takeda Pharmaceutical Company Limited | Preparation of (r)-3-aminopiperidine dihydrochloride |
| GB0606822D0 (en) | 2006-04-05 | 2006-05-17 | Alaska Food Diagnostics | Assay System |
| GB2437311A (en) * | 2006-04-07 | 2007-10-24 | Mologic Ltd | A protease detection product |
| US8324383B2 (en) | 2006-09-13 | 2012-12-04 | Takeda Pharmaceutical Company Limited | Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile |
| MY145447A (en) * | 2006-09-13 | 2012-02-15 | Takeda Pharmaceutical | Use of 2-6(3-amino-piperidin-1-yl)-3-methyl-2, 4-dioxo-3, 4-dihydrp-2h-pyrimidin-1-ylmethyl-4-fluoro-benzonitrile |
| TW200838536A (en) * | 2006-11-29 | 2008-10-01 | Takeda Pharmaceutical | Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor |
| US8293489B2 (en) | 2007-01-31 | 2012-10-23 | Henkin Robert I | Methods for detection of biological substances |
| US8093236B2 (en) | 2007-03-13 | 2012-01-10 | Takeda Pharmaceuticals Company Limited | Weekly administration of dipeptidyl peptidase inhibitors |
| US8580801B2 (en) | 2008-07-23 | 2013-11-12 | Robert I. Henkin | Phosphodiesterase inhibitor treatment |
| CN102818866B (zh) * | 2012-08-03 | 2014-01-22 | 上海交通大学医学院附属新华医院 | 用于新生儿胆道闭锁的诊断标记物的应用 |
| CN106233141B (zh) | 2014-02-18 | 2018-08-21 | 罗伯特·I·汉金 | 用于诊断和治疗味觉或嗅觉的损失和/或失真的方法和组合物 |
| WO2017009214A1 (fr) * | 2015-07-10 | 2017-01-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Méthode précoce et non effractive d'évaluation du risque d'un sujet de développer un syndrome de papillon-lefèvre |
| CH713803B1 (de) | 2016-04-21 | 2023-08-15 | 4TEEN4 Pharmaceuticals GmbH | Verfahren zur Diagnose durch Bestimmung von DPP3, Hemmer der Aktivität von DPP3 und Zusammensetzung mit einem Hemmer. |
| KR20220146538A (ko) | 2020-02-26 | 2022-11-01 | 페아엠 테라그노스틱스 게엠베하 | 치료 목적을 위한 펩티딜글리신 알파-아미드화 모노옥시게나제 (pam)의 용도 |
| US20230097988A1 (en) | 2020-02-26 | 2023-03-30 | Pam Theragnostics Gmbh | Methods for determining peptidylglycine alpha-amidating monooxygenase (pam) and its use for diagnostic purpose |
| US12569493B2 (en) | 2020-03-24 | 2026-03-10 | Cyrano Therapeutics Inc. | Treatment of chemosensory dysfunction from a coronavirus infection |
| JP2023554407A (ja) * | 2020-12-18 | 2023-12-27 | 深▲じぇん▼市▲絵▼云生物科技有限公司 | 新生児胆道閉鎖症のバイオマーカーの使用及び検出方法 |
| CN117288962A (zh) * | 2023-10-09 | 2023-12-26 | 广州市妇女儿童医疗中心 | 检测标志物组合的试剂在制备胆道闭锁诊断产品中的应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4191808A (en) * | 1975-10-30 | 1980-03-04 | Ajinomoto Co., Inc. | Method of measuring dipeptidyl-amino-peptidase activity |
| US4191809A (en) * | 1977-02-26 | 1980-03-04 | Ajinomoto Co., Inc. | Method of measuring enzymatic activity using novel peptide derivatives |
| US4361537A (en) * | 1979-01-12 | 1982-11-30 | Thyroid Diagnostics, Inc. | Test device and method for its use |
| US4299916A (en) * | 1979-12-26 | 1981-11-10 | Syva Company | Preferential signal production on a surface in immunoassays |
| US5122602A (en) * | 1989-02-13 | 1992-06-16 | Miles Inc. | Chromogenic merocyanine enzyme substrates |
-
1994
- 1994-07-14 US US08/275,887 patent/US5601986A/en not_active Expired - Lifetime
-
1995
- 1995-07-13 EP EP95932298A patent/EP0820522B1/fr not_active Expired - Lifetime
- 1995-07-13 CA CA002187783A patent/CA2187783C/fr not_active Expired - Fee Related
- 1995-07-13 PT PT95932298T patent/PT820522E/pt unknown
- 1995-07-13 WO PCT/US1995/008898 patent/WO1996002667A1/fr not_active Ceased
- 1995-07-13 DE DE69522831T patent/DE69522831T2/de not_active Expired - Fee Related
- 1995-07-13 AU AU35381/95A patent/AU3538195A/en not_active Abandoned
- 1995-07-13 DK DK95932298T patent/DK0820522T3/da active
- 1995-07-13 ES ES95932298T patent/ES2160714T3/es not_active Expired - Lifetime
- 1995-07-13 AT AT95932298T patent/ATE205884T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1996002667A1 (fr) | 1996-02-01 |
| EP0820522A1 (fr) | 1998-01-28 |
| DK0820522T3 (da) | 2001-11-19 |
| DE69522831D1 (de) | 2001-10-25 |
| DE69522831T2 (de) | 2002-04-04 |
| CA2187783A1 (fr) | 1996-02-01 |
| ATE205884T1 (de) | 2001-10-15 |
| PT820522E (pt) | 2002-02-28 |
| ES2160714T3 (es) | 2001-11-16 |
| EP0820522B1 (fr) | 2001-09-19 |
| AU3538195A (en) | 1996-02-16 |
| US5601986A (en) | 1997-02-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2187783C (fr) | Dosages et dispositifs de detection de l'atresie des voies biliaires extra-hepatiques | |
| EP0389003B1 (fr) | Dispositif analytique en phase solide et procédé pour son utilisation | |
| JP2818191B2 (ja) | 固相分析装置 | |
| US5358852A (en) | Use of calcium in immunoassay for measurement of C-reactive protein | |
| US5160701A (en) | Solid-phase analytical device and method for using same | |
| JP2999238B2 (ja) | クロマトグラフィーストリップ結合アッセイ装置 | |
| Mansfield et al. | Plasma and urinary trypsinogen activation peptide in healthy dogs, dogs with pancreatitis and dogs with other systemic diseases | |
| US20070224689A1 (en) | Method for predicting or identifying the onset of premature membrane rupture during pregnancy | |
| US8404479B2 (en) | Simple membrane assay method and kit | |
| US5994085A (en) | Methods and devices for detecting non-complexed prostate specific antigen | |
| JP2676108B2 (ja) | 血液滴または任意の生物媒質に由来する液からの物質の免疫酵素的検出装置 | |
| CN102680698A (zh) | 中性粒细胞明胶酶相关脂质运载蛋白(ngal)测定试剂盒(胶乳增强免疫比浊法) | |
| US20080227208A1 (en) | Devices and Methods for Detection of Occult Blood | |
| EP0293395A1 (fr) | Test de depistage de cancers | |
| JP3304214B2 (ja) | 簡易測定方法及び簡易測定装置 | |
| KR19980703302A (ko) | 글루타치온 s-트랜스퍼라제의 하나 또는 그 이상의 아이소엔자임 검출에 기초한 장기 상태 평가를 위한 쾌속 검정법 | |
| Gebhard et al. | Dermatitis Herpetiformis IMMUNOLOGIC CONCOMITANTS OF SMALL INTESTINAL DISEASE AND RELATIONSHIP TO HISTOCOMPATIBILITY ANTIGEN HL-A8 | |
| US7015005B2 (en) | Methods and devices for detecting non-complexed prostate specific antigen | |
| JPH0580053A (ja) | ヒト子宮体癌細胞の免疫化学的検出方法 | |
| JP3547729B2 (ja) | アッセイ | |
| CA1193192A (fr) | Methode de dosage de la kallikreine dans l'urine et trousse utilisee a cette fin | |
| JP4470354B2 (ja) | １〜１００ｕｌの試料のためのインビボ検査装置 | |
| JPH02154679A (ja) | 医療用検査容器 | |
| JP3522764B2 (ja) | 遊離及び複合化トリプシノーゲン−２のアッセイ | |
| JPH08220099A (ja) | 物質の検出試薬及び慢性関節リウマチの検知法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |