CA2192678C - Proteine et gene mn - Google Patents

Proteine et gene mn Download PDF

Info

Publication number
CA2192678C
CA2192678C CA2192678A CA2192678A CA2192678C CA 2192678 C CA2192678 C CA 2192678C CA 2192678 A CA2192678 A CA 2192678A CA 2192678 A CA2192678 A CA 2192678A CA 2192678 C CA2192678 C CA 2192678C
Authority
CA
Canada
Prior art keywords
cells
proteins
protein
gene
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2192678A
Other languages
English (en)
Other versions
CA2192678A1 (fr
Inventor
Jan Zavada
Silvia Pastorekova
Jaromir Pastorek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institute of Virology (Slovak Academy of Science)
Original Assignee
Institute of Virology (Slovak Academy of Science)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/260,190 external-priority patent/US6774117B1/en
Priority claimed from US08/487,077 external-priority patent/US6069242A/en
Priority claimed from US08/485,863 external-priority patent/US6093548A/en
Priority claimed from US08/485,049 external-priority patent/US6204370B1/en
Priority claimed from US08/486,756 external-priority patent/US5981711A/en
Priority claimed from US08/481,658 external-priority patent/US5955075A/en
Priority claimed from US08/485,862 external-priority patent/US5989838A/en
Application filed by Institute of Virology (Slovak Academy of Science) filed Critical Institute of Virology (Slovak Academy of Science)
Publication of CA2192678A1 publication Critical patent/CA2192678A1/fr
Publication of CA2192678C publication Critical patent/CA2192678C/fr
Application granted granted Critical
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Cell Biology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

L'invention concerne une séquence du génome complète comprenant une séquence d'ADNc entière pour le gène MN, un oncogène putatif, ainsi que des protéines/polypeptides codés par cette séquence. Elle porte aussi sur des molécules d'acide nucléique recombinées pour exprimer des protéines/polypeptides MN et des protéines recombinées. On décrit l'expression du gène MN comme étant associée à la tumorigénicité, et l'invention se rapporte à des procédés et compositions pour détecter et/ou quantifier l'antigène MN et/ou les anticorps spécifiques de MN dans des échantillons de vertébrés et constituant un moyen diagnostique/pronostique pour les maladies néoplasiques et pré-néoplasiques. Des trousses pour les dosages immunologiques selon l'invention sont également décrites. Des anticorps spécifiques de MN pouvant être utilisés pour le diagnostic/pronostic et le traitement, pour l'imagerie et/ou la purification par affinité des protéines/polypeptides MN sont décrits, ainsi que des sondes d'acide nucléique pour le gène MN et des trousses d'essai contenant lesdites sondes. L'invention concerne également des vaccins qui comprennent les protéines/polypeptides MN et sont efficaces pour immuniser efficacement un vertébré contre les maladies néoplasiques associées à l'expression des protéines MN. Elle porte également sur des séquences d'acides nucléiques antisens qui peuvent être utilisées pour inhiber l'expression du gène MN, et des techniques d'amplification en chaîne (PCR) pour détecter les réorganisations génétiques dans les gènes MN.
CA2192678A 1994-06-15 1995-06-15 Proteine et gene mn Expired - Lifetime CA2192678C (fr)

Applications Claiming Priority (17)

Application Number Priority Date Filing Date Title
US08/260,190 US6774117B1 (en) 1992-03-11 1994-06-15 MN gene and protein
US44750495A 1995-06-07 1995-06-07
US08/447,504 1995-06-07
US08/485,049 1995-06-07
US08/487,077 1995-06-07
US08/486,756 1995-06-07
US08/485,863 US6093548A (en) 1992-03-11 1995-06-07 Detection and quantitation of MN-specific antibodies.
US08/485,049 US6204370B1 (en) 1992-03-11 1995-06-07 MN gene and protein
US08/486,756 US5981711A (en) 1992-03-11 1995-06-07 MN-specific antibodies and hybridomas
US08/481,658 US5955075A (en) 1992-03-11 1995-06-07 Method of inhibiting tumor growth using antibodies to MN protein
US08/481,658 1995-06-07
US08/485,862 1995-06-07
US08/487,077 US6069242A (en) 1992-03-11 1995-06-07 MN gene and protein
US08/485,863 1995-06-07
US08/260,190 1995-06-07
US08/485,862 US5989838A (en) 1992-03-11 1995-06-07 Immunological methods of detecting MN proteins and MN polypeptides
PCT/US1995/007628 WO1995034650A2 (fr) 1994-06-15 1995-06-15 Proteine et gene mn

Publications (2)

Publication Number Publication Date
CA2192678A1 CA2192678A1 (fr) 1995-12-21
CA2192678C true CA2192678C (fr) 2010-12-14

Family

ID=27575294

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2192678A Expired - Lifetime CA2192678C (fr) 1994-06-15 1995-06-15 Proteine et gene mn

Country Status (3)

Country Link
AU (1) AU2861695A (fr)
CA (1) CA2192678C (fr)
WO (1) WO1995034650A2 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6297041B1 (en) 1992-03-11 2001-10-02 Institute Of Virology, Slovak Academy Of Sciences MN gene and protein
US5387676A (en) * 1992-03-11 1995-02-07 Ciba Corning Diagnostics Corp. MN gene and protein
US6297051B1 (en) 1997-01-24 2001-10-02 Institute Of Virology, Slovak Academy Of Sciences MN gene and protein
ES2296412T3 (es) * 1998-10-23 2008-04-16 Institute Of Virology Gen y proteina mn.
US7713704B1 (en) 1998-10-23 2010-05-11 Institute Of Virology Of The Slovak Academy Of Science MN gene and protein
US7910691B2 (en) 1999-10-22 2011-03-22 Institute Of Virology Of The Slovak Academy Of Sciences MN gene and protein
US6902890B1 (en) 1999-11-04 2005-06-07 Diadexus, Inc. Method of diagnosing monitoring, staging, imaging and treating cancer
WO2001060317A2 (fr) 2000-02-14 2001-08-23 The Regents Of The University Of California Vaccin contre les tumeurs specifiques du rein, dirige contre l'antigene g-250 de la tumeur du rein
AR036833A1 (es) * 2001-10-18 2004-10-06 Bayer Corp Anticuerpos humanos que se unen a mn y tienen actividad neutralizante de la adhesion celular.
US7910549B2 (en) 2001-12-13 2011-03-22 Institute Of Virology Of The Slovak Academy Of Sciences MN gene and protein
SI2508596T1 (sl) 2002-02-21 2016-01-29 Institute Of Virology Slovak Academy Of Sciences Monoklonska protitelesa, specifična za MN/CA IX, proizvedena iz MN/CA IX deficientnih miši, in postopki uporabe
HUE026218T2 (en) 2002-02-21 2016-05-30 Inst Virology MN / CA IX-Specific Monoclonal Antibodies and Methods for MN / CA IX Deficient Mice
DE60328477D1 (de) * 2002-04-16 2009-09-03 Univ California Verfahren zur prognose von nierenzellkarzinom und behandlungsauswahl mit carboanhydrase ix
US7550424B2 (en) 2002-11-26 2009-06-23 Institute Of Virology Slovak Academy Of Sciences CA IX-specific inhibitors
EP1743038A4 (fr) 2004-05-04 2007-11-21 Bayer Healthcare Mn/ca ix/ ca9 et pronostic du cancer du rein
US20100056611A1 (en) 2006-10-12 2010-03-04 Jaromir Pastorek MN/CA9 Splice Variants
US7820159B2 (en) 2006-10-31 2010-10-26 Instiute of Virology of the Slovak Academy of Sciences MN/CA IX and EGFR pathway inhibition
JP2010514422A (ja) 2006-12-22 2010-05-06 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 新規ｔａａ変種に基づく新たな融合分子
US8097423B2 (en) 2007-07-30 2012-01-17 Institute Of Virology MN/CA IX and breast cancer therapy
BR112015020061A8 (pt) 2013-02-22 2018-01-23 Wilex Ag composto alvo anidrase carbônica ix (caix) para tratamento de câncer, seus usos, composição farmcêutica, e método para diagnosticar, prognosticar e/ou classificar um câncer

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5387676A (en) * 1992-03-11 1995-02-07 Ciba Corning Diagnostics Corp. MN gene and protein

Also Published As

Publication number Publication date
AU2861695A (en) 1996-01-05
WO1995034650A3 (fr) 1996-02-15
MX9606402A (es) 1998-10-31
WO1995034650A2 (fr) 1995-12-21
CA2192678A1 (fr) 1995-12-21

Similar Documents

Publication Publication Date Title
US7816496B2 (en) MN gene and protein
US7186514B2 (en) MN gene and protein
CA2192678C (fr) Proteine et gene mn
US20090118473A1 (en) MN Gene and Protein
WO1995034650A9 (fr) Proteine et gene mn
US5955075A (en) Method of inhibiting tumor growth using antibodies to MN protein
US8012707B2 (en) MN gene and protein
US5989838A (en) Immunological methods of detecting MN proteins and MN polypeptides
US5981711A (en) MN-specific antibodies and hybridomas
EP1123387B1 (fr) Gene et proteine mn
US6069242A (en) MN gene and protein
US6093548A (en) Detection and quantitation of MN-specific antibodies.
US5972353A (en) MN proteins, polypeptides, fusion proteins and fusion polypeptides
EP1595947B1 (fr) Gène MN et protéine MN
US20080214787A1 (en) MN Gene and Protein
HK1084148B (en) Mn gene and protein
JP3977416B6 (ja) Ｍｎ遺伝子およびｍｎ蛋白質
MXPA96006402A (es) Gen y proteina mn

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20150615