CA2197062C - Composition pour l'administration de medicaments, renfermant du chitosane ou un derive de celui-ci, avec un potentiel zeta bien defini - Google Patents

Composition pour l'administration de medicaments, renfermant du chitosane ou un derive de celui-ci, avec un potentiel zeta bien defini Download PDF

Info

Publication number: CA2197062C
Authority: CA; Canada
Prior art keywords: chitosan; microspheres; particles; composition according; active compound
Prior art date: 1994-08-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

CA002197062A

Other languages

English (en)

Other versions

CA2197062A1 (fr

Inventor

Peter James Watts

Lisbeth Illum

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Kyowa Kirin Services Ltd

Original Assignee

Archimedes Development Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-08-20

Filing date

1995-08-21

Publication date

2007-10-09

1994-08-20 Priority claimed from GB9416884A external-priority patent/GB9416884D0/en

1995-08-21 Application filed by Archimedes Development Ltd filed Critical Archimedes Development Ltd

1996-02-29 Publication of CA2197062A1 publication Critical patent/CA2197062A1/fr

2007-10-09 Application granted granted Critical

2007-10-09 Publication of CA2197062C publication Critical patent/CA2197062C/fr

2015-08-21 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

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IAIWVQXQOWNYOU-FPYGCLRLSA-N nitrofural Chemical compound NC(=O)N\N=C\C1=CC=C([N+]([O-])=O)O1 IAIWVQXQOWNYOU-FPYGCLRLSA-N 0.000 description 1
229960001907 nitrofurazone Drugs 0.000 description 1
239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 1
229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
229960005343 ondansetron Drugs 0.000 description 1
229940126701 oral medication Drugs 0.000 description 1
239000012074 organic phase Substances 0.000 description 1
230000003647 oxidation Effects 0.000 description 1
238000007254 oxidation reaction Methods 0.000 description 1
BEEDODBODQVSIM-UHFFFAOYSA-N oxymetazoline hydrochloride Chemical compound Cl.CC1=CC(C(C)(C)C)=C(O)C(C)=C1CC1=NCCN1 BEEDODBODQVSIM-UHFFFAOYSA-N 0.000 description 1
229960005162 oxymetazoline hydrochloride Drugs 0.000 description 1
229960003207 papaverine hydrochloride Drugs 0.000 description 1
229960005489 paracetamol Drugs 0.000 description 1
238000005192 partition Methods 0.000 description 1
239000008188 pellet Substances 0.000 description 1
230000035515 penetration Effects 0.000 description 1
229940049954 penicillin Drugs 0.000 description 1
150000002960 penicillins Chemical class 0.000 description 1
229960004448 pentamidine Drugs 0.000 description 1
XDRYMKDFEDOLFX-UHFFFAOYSA-N pentamidine Chemical compound C1=CC(C(=N)N)=CC=C1OCCCCCOC1=CC=C(C(N)=N)C=C1 XDRYMKDFEDOLFX-UHFFFAOYSA-N 0.000 description 1
230000035699 permeability Effects 0.000 description 1
229940066827 pertussis vaccine Drugs 0.000 description 1
239000003208 petroleum Substances 0.000 description 1
229960002895 phenylbutazone Drugs 0.000 description 1
VYMDGNCVAMGZFE-UHFFFAOYSA-N phenylbutazonum Chemical compound O=C1C(CCCC)C(=O)N(C=2C=CC=CC=2)N1C1=CC=CC=C1 VYMDGNCVAMGZFE-UHFFFAOYSA-N 0.000 description 1
OCYSGIYOVXAGKQ-FVGYRXGTSA-N phenylephrine hydrochloride Chemical compound [H+].[Cl-].CNC[C@H](O)C1=CC=CC(O)=C1 OCYSGIYOVXAGKQ-FVGYRXGTSA-N 0.000 description 1
229960003733 phenylephrine hydrochloride Drugs 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
150000003904 phospholipids Chemical class 0.000 description 1
150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 1
CLSUSRZJUQMOHH-UHFFFAOYSA-L platinum dichloride Chemical compound Cl[Pt]Cl CLSUSRZJUQMOHH-UHFFFAOYSA-L 0.000 description 1
230000010287 polarization Effects 0.000 description 1
229920000867 polyelectrolyte Polymers 0.000 description 1
229920001184 polypeptide Polymers 0.000 description 1
229920001282 polysaccharide Polymers 0.000 description 1
239000005017 polysaccharide Substances 0.000 description 1
239000001103 potassium chloride Substances 0.000 description 1
235000011164 potassium chloride Nutrition 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
229960005205 prednisolone Drugs 0.000 description 1
OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 1
229960004618 prednisone Drugs 0.000 description 1
XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 description 1
DBABZHXKTCFAPX-UHFFFAOYSA-N probenecid Chemical compound CCCN(CCC)S(=O)(=O)C1=CC=C(C(O)=O)C=C1 DBABZHXKTCFAPX-UHFFFAOYSA-N 0.000 description 1
229960003081 probenecid Drugs 0.000 description 1
230000001737 promoting effect Effects 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
230000002685 pulmonary effect Effects 0.000 description 1
238000012552 review Methods 0.000 description 1
229960002052 salbutamol Drugs 0.000 description 1
235000019515 salmon Nutrition 0.000 description 1
229940125723 sedative agent Drugs 0.000 description 1
239000000932 sedative agent Substances 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
239000001488 sodium phosphate Substances 0.000 description 1
229910000162 sodium phosphate Inorganic materials 0.000 description 1
JGMJQSFLQWGYMQ-UHFFFAOYSA-M sodium;2,6-dichloro-n-phenylaniline;acetate Chemical compound [Na+].CC([O-])=O.ClC1=CC=CC(Cl)=C1NC1=CC=CC=C1 JGMJQSFLQWGYMQ-UHFFFAOYSA-M 0.000 description 1
239000007787 solid Substances 0.000 description 1
238000000935 solvent evaporation Methods 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
239000012086 standard solution Substances 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
230000003637 steroidlike Effects 0.000 description 1
JNMRHUJNCSQMMB-UHFFFAOYSA-N sulfathiazole Chemical compound C1=CC(N)=CC=C1S(=O)(=O)NC1=NC=CS1 JNMRHUJNCSQMMB-UHFFFAOYSA-N 0.000 description 1
229960001544 sulfathiazole Drugs 0.000 description 1
150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
229910021653 sulphate ion Inorganic materials 0.000 description 1
KQKPFRSPSRPDEB-UHFFFAOYSA-N sumatriptan Chemical compound CNS(=O)(=O)CC1=CC=C2NC=C(CCN(C)C)C2=C1 KQKPFRSPSRPDEB-UHFFFAOYSA-N 0.000 description 1
229960003708 sumatriptan Drugs 0.000 description 1
239000000829 suppository Substances 0.000 description 1
230000002459 sustained effect Effects 0.000 description 1
238000013268 sustained release Methods 0.000 description 1
239000012730 sustained-release form Substances 0.000 description 1
239000003826 tablet Substances 0.000 description 1
230000008685 targeting Effects 0.000 description 1
238000009864 tensile test Methods 0.000 description 1
229960002766 tetanus vaccines Drugs 0.000 description 1
229960004989 tetracycline hydrochloride Drugs 0.000 description 1
BJORNXNYWNIWEY-UHFFFAOYSA-N tetrahydrozoline hydrochloride Chemical compound Cl.N1CCN=C1C1C2=CC=CC=C2CCC1 BJORNXNYWNIWEY-UHFFFAOYSA-N 0.000 description 1
229940021790 tetrahydrozoline hydrochloride Drugs 0.000 description 1
230000002992 thymic effect Effects 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
229960001262 tramazoline Drugs 0.000 description 1
229960005294 triamcinolone Drugs 0.000 description 1
GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 description 1
229960002117 triamcinolone acetonide Drugs 0.000 description 1
YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 description 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
229940044950 vaginal gel Drugs 0.000 description 1
239000000029 vaginal gel Substances 0.000 description 1
229940120293 vaginal suppository Drugs 0.000 description 1
239000006216 vaginal suppository Substances 0.000 description 1
229940044977 vaginal tablet Drugs 0.000 description 1
239000000003 vaginal tablet Substances 0.000 description 1
239000005526 vasoconstrictor agent Substances 0.000 description 1
229940124549 vasodilator Drugs 0.000 description 1
239000003071 vasodilator agent Substances 0.000 description 1
229960003726 vasopressin Drugs 0.000 description 1
238000005406 washing Methods 0.000 description 1
239000012991 xanthate Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

CA002197062A 1994-08-20 1995-08-21 Composition pour l'administration de medicaments, renfermant du chitosane ou un derive de celui-ci, avec un potentiel zeta bien defini Expired - Lifetime CA2197062C (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB9416884.6		1994-08-20
GB9416884A GB9416884D0 (en)	1994-08-20	1994-08-20	Drug delivery compositions
PCT/GB1995/001980 WO1996005810A1 (fr)	1994-08-20	1995-08-21	Composition d'apport de medicaments contenant du chitosane, ou un de ses derives, a potentiel zeta defini

Publications (2)

Publication Number	Publication Date
CA2197062A1 CA2197062A1 (fr)	1996-02-29
CA2197062C true CA2197062C (fr)	2007-10-09

Family

ID=38596221

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002197062A Expired - Lifetime CA2197062C (fr)	1994-08-20	1995-08-21	Composition pour l'administration de medicaments, renfermant du chitosane ou un derive de celui-ci, avec un potentiel zeta bien defini

Country Status (1)

Country	Link
CA (1)	CA2197062C (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN115305544A (zh) *	2022-08-09	2022-11-08	河南大学	一种镁合金表面抗菌生物活性涂层及其制备方法和应用

1995
- 1995-08-21 CA CA002197062A patent/CA2197062C/fr not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CA2197062A1 (fr)	1996-02-29

Legal Events

Date	Code	Title	Description
2002-08-16	EEER	Examination request
2015-10-25	MKEX	Expiry	Effective date: 20150821

Publication	Publication Date	Title
EP0776195B1 (fr)	2001-11-07	Composition d'apport de medicaments contenant du chitosane, ou un de ses derives, a potentiel zeta defini
EP0952822B1 (fr)	2003-04-02	Microparticules a base de chitosane et de gelatine de type a
CA2060176C (fr)	2001-01-09	Compositions pharmaceutiques a petites particules
EP0460020B1 (fr)	1994-04-20	Compositions pour l'administration de medicaments
CA1333258C (fr)	1994-11-29	Formules pour administration a travers les muqueuses
US5554388A (en)	1996-09-10	Systemic drug delivery compositions comprising a polycationi substance
AU614290B2 (en)	1991-08-29	Enhanced uptake drug delivery system
US5725871A (en)	1998-03-10	Drug delivery compositions comprising lysophosphoglycerolipid
US5744166A (en)	1998-04-28	Drug delivery compositions
US5804212A (en)	1998-09-08	Small particle compositions for intranasal drug delivery
KR20120084303A (ko)	2012-07-27	약물 함유 미립자를 포함하는 의약 조성물 및 그 제조 방법
EP0487562B1 (fr)	1995-03-08	Compositions pharmaceutiques
CA2197062C (fr)	2007-10-09	Composition pour l'administration de medicaments, renfermant du chitosane ou un derive de celui-ci, avec un potentiel zeta bien defini
AU617376C (en)	1992-08-20	A drug composition with microspheres and process for its preparation
AU617376B2 (en)	1991-11-28	A drug composition with microspheres and process for its preparation