CA2201349A1 - Inhibiteurs de transferase de farnesyl-proteine - Google Patents

Inhibiteurs de transferase de farnesyl-proteine

Info

Publication number
CA2201349A1
CA2201349A1 CA 2201349 CA2201349A CA2201349A1 CA 2201349 A1 CA2201349 A1 CA 2201349A1 CA 2201349 CA2201349 CA 2201349 CA 2201349 A CA2201349 A CA 2201349A CA 2201349 A1 CA2201349 A1 CA 2201349A1
Authority
CA
Canada
Prior art keywords
glycyl
pyrrolidin
substituted
ylmethyl
methionine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2201349
Other languages
English (en)
Inventor
Neville J. Anthony
S. Jane Desolms
Samuel L. Graham
Gerald E. Stokker
Catherine M. Wiscount
Terrence M. Ciccarone
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/527,972 external-priority patent/US5661161A/en
Application filed by Individual filed Critical Individual
Publication of CA2201349A1 publication Critical patent/CA2201349A1/fr
Abandoned legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Analogues du motif CAAX de la protéine Ras modifiée par farnésylation in vivo. Ces analogues CAAX interdisent la transférase de la farnésyl-protéine. Ils diffèrent en outre de ceux décrits antérieurement en tant qu'inhibiteurs de transférase de la farnésyl-protéine par le fait qu'ils ne comprennent pas de fraction thiol. L'absence de thiol présente des avantages particuliers sur le plan du comportement pharmacocinétique chez les animaux, de la prévention des réactions chimiques dépendantes d'un thiol, telles que l'auto-oxydation rapide et la formation de disulfure avec des thiols endogènes, ainsi qu'une toxicité systémique réduite. L'invention porte également sur des compositions chimiothérapeutiques renfermant de tels inhibiteurs de farnésyl-transférase et sur leurs procédés de production.
CA 2201349 1994-09-29 1995-09-27 Inhibiteurs de transferase de farnesyl-proteine Abandoned CA2201349A1 (fr)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US31516194A 1994-09-29 1994-09-29
US315,161 1994-09-29
US39928295A 1995-03-06 1995-03-06
US399,282 1995-03-06
US47207795A 1995-06-06 1995-06-06
US472,077 1995-06-06
US527,972 1995-09-14
US08/527,972 US5661161A (en) 1994-09-29 1995-09-14 Inhibitors of farnesyl-protein transferase
PCT/US1995/012474 WO1996010035A1 (fr) 1994-09-29 1995-09-27 Inhibiteurs de transferase de farnesyl-proteine

Publications (1)

Publication Number Publication Date
CA2201349A1 true CA2201349A1 (fr) 1996-04-04

Family

ID=29408141

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2201349 Abandoned CA2201349A1 (fr) 1994-09-29 1995-09-27 Inhibiteurs de transferase de farnesyl-proteine

Country Status (1)

Country Link
CA (1) CA2201349A1 (fr)

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Legal Events

Date Code Title Description
FZDE Dead