CA2206211C - Dispositif de liberation controlee d'une suspension medicamenteuse - Google Patents

Dispositif de liberation controlee d'une suspension medicamenteuse Download PDF

Info

Publication number
CA2206211C
CA2206211C CA002206211A CA2206211A CA2206211C CA 2206211 C CA2206211 C CA 2206211C CA 002206211 A CA002206211 A CA 002206211A CA 2206211 A CA2206211 A CA 2206211A CA 2206211 C CA2206211 C CA 2206211C
Authority
CA
Canada
Prior art keywords
core
polymer
hydration
coating
layer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002206211A
Other languages
English (en)
Other versions
CA2206211A1 (fr
Inventor
Gerald S. Rork
James D. Pipkin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/363,451 external-priority patent/US5582838A/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of CA2206211A1 publication Critical patent/CA2206211A1/fr
Application granted granted Critical
Publication of CA2206211C publication Critical patent/CA2206211C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne un dispositif conçu pour la libération contrôlée d'un agent bénéfique. Il comprend (i) un noyau constitué d'au moins deux couches, dont au moins une renferme un agent bénéfique et un polymère qui prend la forme de perles de gel microscopiques en s'hydratant et au moins une autre couche qui renferme un polymère qui revêt la forme de perles de gel microscopiques à l'hydratation; et (ii) un revêtement imperméable, insoluble qui entoure et adhère au noyau et qui est pourvu d'ouvertures servant de surface d'hydratation et permettant la libération des perles de gel microscopiques.
CA002206211A 1994-12-22 1995-12-18 Dispositif de liberation controlee d'une suspension medicamenteuse Expired - Fee Related CA2206211C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/363,451 US5582838A (en) 1994-12-22 1994-12-22 Controlled release drug suspension delivery device
US363,451 1994-12-22
PCT/US1995/016530 WO1996019201A1 (fr) 1994-12-22 1995-12-18 Dispositif de liberation controlee d'une suspension medicamenteuse

Publications (2)

Publication Number Publication Date
CA2206211A1 CA2206211A1 (fr) 1996-06-27
CA2206211C true CA2206211C (fr) 2006-08-08

Family

ID=36791734

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002206211A Expired - Fee Related CA2206211C (fr) 1994-12-22 1995-12-18 Dispositif de liberation controlee d'une suspension medicamenteuse

Country Status (1)

Country Link
CA (1) CA2206211C (fr)

Also Published As

Publication number Publication date
CA2206211A1 (fr) 1996-06-27

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CA2206211C (fr) Dispositif de liberation controlee d'une suspension medicamenteuse

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed