CA2207334C - Preparations granulaires a liberation prolongee et procede pour leur production - Google Patents
Preparations granulaires a liberation prolongee et procede pour leur production Download PDFInfo
- Publication number
- CA2207334C CA2207334C CA002207334A CA2207334A CA2207334C CA 2207334 C CA2207334 C CA 2207334C CA 002207334 A CA002207334 A CA 002207334A CA 2207334 A CA2207334 A CA 2207334A CA 2207334 C CA2207334 C CA 2207334C
- Authority
- CA
- Canada
- Prior art keywords
- sustained
- granules
- polymer
- plasticizer
- granular preparations
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
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- MTKNGOHFNXIVOS-UHFFFAOYSA-N ticlopidine hydrochloride Chemical compound [H+].[Cl-].ClC1=CC=CC=C1CN1CC(C=CS2)=C2CC1 MTKNGOHFNXIVOS-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
La présente invention concerne une préparation granulaire à libération prolongée qui est excellente pour ce qui concerne la diffusion lente et inoffensive pour l'organisme humain. Elle peut être produite aisément, d'une manière simple, par granulation par voie humide d'une suspension aqueuse contenant un principe actif efficace sur le plan médical, un polymère particulaire ayant un diamètre moyen de particules de 50 <m ou moins, et un plastifiant, et par traitement des granulés obtenus à la plus basse des températures suivantes: la plus basse température de formation d'un film pour un mélange du polymère et du plastifiant, et sa température de transition vitreuse.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP31441494 | 1994-12-19 | ||
| JP314414/1994 | 1994-12-19 | ||
| PCT/JP1995/002594 WO1996019200A1 (fr) | 1994-12-19 | 1995-12-18 | Preparation granulaire a liberation prolongee et procede de production |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2207334A1 CA2207334A1 (fr) | 1996-06-27 |
| CA2207334C true CA2207334C (fr) | 2006-08-22 |
Family
ID=36939171
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002207334A Expired - Fee Related CA2207334C (fr) | 1994-12-19 | 1995-12-18 | Preparations granulaires a liberation prolongee et procede pour leur production |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2207334C (fr) |
-
1995
- 1995-12-18 CA CA002207334A patent/CA2207334C/fr not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2207334A1 (fr) | 1996-06-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |