CA2211190A1 - Detecteur d'hemolyse jetable - Google Patents
Detecteur d'hemolyse jetableInfo
- Publication number
- CA2211190A1 CA2211190A1 CA 2211190 CA2211190A CA2211190A1 CA 2211190 A1 CA2211190 A1 CA 2211190A1 CA 2211190 CA2211190 CA 2211190 CA 2211190 A CA2211190 A CA 2211190A CA 2211190 A1 CA2211190 A1 CA 2211190A1
- Authority
- CA
- Canada
- Prior art keywords
- volume
- sample
- sealed chamber
- hemolysis
- chamber
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 206010018910 Haemolysis Diseases 0.000 title claims abstract description 131
- 230000008588 hemolysis Effects 0.000 title claims abstract description 131
- 239000012528 membrane Substances 0.000 claims abstract description 140
- 210000004369 blood Anatomy 0.000 claims abstract description 132
- 239000008280 blood Substances 0.000 claims abstract description 132
- 238000012360 testing method Methods 0.000 claims abstract description 28
- 239000012530 fluid Substances 0.000 claims abstract description 25
- 238000000034 method Methods 0.000 claims abstract description 23
- 238000001514 detection method Methods 0.000 claims abstract description 20
- 239000012466 permeate Substances 0.000 claims abstract description 20
- 238000009736 wetting Methods 0.000 claims description 21
- 230000001131 transforming effect Effects 0.000 claims description 8
- 210000000601 blood cell Anatomy 0.000 claims description 6
- 230000003287 optical effect Effects 0.000 claims description 3
- 210000002381 plasma Anatomy 0.000 description 83
- 238000002347 injection Methods 0.000 description 41
- 239000007924 injection Substances 0.000 description 41
- 239000000243 solution Substances 0.000 description 23
- 239000003570 air Substances 0.000 description 19
- 239000012982 microporous membrane Substances 0.000 description 17
- 102000001554 Hemoglobins Human genes 0.000 description 13
- 108010054147 Hemoglobins Proteins 0.000 description 13
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 12
- 239000000470 constituent Substances 0.000 description 12
- 230000001413 cellular effect Effects 0.000 description 11
- 230000004888 barrier function Effects 0.000 description 8
- 239000004033 plastic Substances 0.000 description 8
- 229920003023 plastic Polymers 0.000 description 8
- 239000011148 porous material Substances 0.000 description 8
- 230000005465 channeling Effects 0.000 description 6
- 238000010586 diagram Methods 0.000 description 6
- 239000004263 Guaiac resin Substances 0.000 description 5
- 229920000932 Gum guaicum Polymers 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
- 235000019278 guaiac resin Nutrition 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 238000003466 welding Methods 0.000 description 5
- 241000147041 Guaiacum officinale Species 0.000 description 4
- 229940091561 guaiac Drugs 0.000 description 4
- 239000002991 molded plastic Substances 0.000 description 4
- 239000000080 wetting agent Substances 0.000 description 4
- 210000003743 erythrocyte Anatomy 0.000 description 3
- 230000002209 hydrophobic effect Effects 0.000 description 3
- 229920000126 latex Polymers 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 229920001971 elastomer Polymers 0.000 description 2
- 230000005484 gravity Effects 0.000 description 2
- 239000004816 latex Substances 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 206010020843 Hyperthermia Diseases 0.000 description 1
- 241000220324 Pyrus Species 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 239000012080 ambient air Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 239000013013 elastic material Substances 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 238000001631 haemodialysis Methods 0.000 description 1
- 230000000322 hemodialysis Effects 0.000 description 1
- 230000036031 hyperthermia Effects 0.000 description 1
- 239000003547 immunosorbent Substances 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 235000021017 pears Nutrition 0.000 description 1
- 229920002492 poly(sulfone) Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/491—Blood by separating the blood components
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Ecology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Abstract
Procédé et appareil de détection d'hémolyse dans un échantillon de sang d'un patient. Une chambre hermétiquement fermée ayant un volume fixe est prévue pour recevoir l'échantillon de sang. Cette chambre a une pression interne due à la présence d'une quantité fixe d'air. Un volume de fluide que représente l'échantillon de sang est réceptionné dans la chambre hermétiquement fermée. Alors que l'échantillon passe dans ladite chambre, la pression interne de la chambre monte en retenant la quantité fixe d'air à l'intérieur de celle-ci au moment où le fluide arrive dans la chambre. L'augmentation de la pression interne fait passer la partie plasma de l'échantillon de sang se trouvant dans la chambre à travers une membrane qui forme au moins une partie d'un côté de la chambre. Un volume de test de la partie plasma de l'échantillon de sang est réceptionné par un dispositif de détection d'hémolyse après avoir traversé la membrane, et un état d'hémolyse est détecté d'après une teinte associée au volume de test réceptionné dans le dispositif de détection d'hémolyse.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37821095A | 1995-01-25 | 1995-01-25 | |
| US08/378,210 | 1995-01-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2211190A1 true CA2211190A1 (fr) | 1996-08-01 |
Family
ID=23492210
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2211190 Abandoned CA2211190A1 (fr) | 1995-01-25 | 1996-01-17 | Detecteur d'hemolyse jetable |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0805981A1 (fr) |
| JP (1) | JPH10513259A (fr) |
| AU (1) | AU4657696A (fr) |
| CA (1) | CA2211190A1 (fr) |
| WO (1) | WO1996023223A1 (fr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4210783B2 (ja) | 2002-09-26 | 2009-01-21 | アークレイ株式会社 | 分析用具 |
| JP4262466B2 (ja) | 2002-10-28 | 2009-05-13 | アークレイ株式会社 | 分析用具および分析装置 |
| EP2264453B1 (fr) | 2009-06-17 | 2013-04-03 | Leukocare Ag | Procédé de filtrage de sang |
| EP2580590A1 (fr) * | 2010-06-10 | 2013-04-17 | Hemcheck Sweden Aktiebolag | Dispositif de détection d'hémolyse |
| JP5659960B2 (ja) * | 2011-06-09 | 2015-01-28 | コニカミノルタ株式会社 | 細胞平面展開方法 |
| SE536634C2 (sv) | 2011-12-09 | 2014-04-15 | Hemcheck Sweden Ab | Anordning för detektion av hemolys |
| GB2504138A (en) * | 2012-07-20 | 2014-01-22 | Emco Packaging Systems Ltd | A self-contained, rapid field diagnostic system for blood samples |
| JP6357473B2 (ja) * | 2012-08-08 | 2018-07-11 | コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． | 一滴の血液を使用した血漿分離 |
| DE102013205346A1 (de) | 2013-03-26 | 2014-10-02 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Lanthanoidkomplexbasierte spektroskopische Hämoglobinbestimmung in einem flüssigen biologischen Medium |
| CA2962931C (fr) * | 2014-09-30 | 2021-12-14 | Siemens Healthcare Diagnostics Inc. | Dispositif, systeme et procede de detection d'hemolyse |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4486536A (en) * | 1982-05-28 | 1984-12-04 | Smithkline Diagnostics, Inc. | Specimen slide for occult blood testing |
| US4639316A (en) * | 1984-12-14 | 1987-01-27 | Becton, Dickinson And Company | Automatic liquid component separator |
| ES2041668T3 (es) * | 1986-10-29 | 1993-12-01 | Asahi Medical Co., Ltd. | Unidad de recogida de componentes de la sangre. |
| US4789526A (en) * | 1986-12-15 | 1988-12-06 | Pall Corporation | Vacuum diagnostic device |
| US4995967A (en) * | 1987-11-06 | 1991-02-26 | Akzo N.V. | Separator for cell-containing liquids |
| SE465355B (sv) * | 1989-12-07 | 1991-09-02 | Provivo Ab | Engaangsfilter och foerfarande foer filtrering av en partikelbemaengd vaetskevolym |
| JP3003152B2 (ja) * | 1990-03-20 | 2000-01-24 | 吉富製薬株式会社 | 遊離ヘモグロビンの測定法及びそれに用いる遊離ヘモグロビン測定用試薬キット |
| US5330420A (en) * | 1992-01-13 | 1994-07-19 | Therakos, Inc. | Hemolysis detector |
| US5416026A (en) * | 1993-10-04 | 1995-05-16 | I-Stat Corporation | Method for detecting the change in an analyte due to hemolysis in a fluid sample |
-
1996
- 1996-01-17 CA CA 2211190 patent/CA2211190A1/fr not_active Abandoned
- 1996-01-17 JP JP8522920A patent/JPH10513259A/ja active Pending
- 1996-01-17 AU AU46576/96A patent/AU4657696A/en not_active Abandoned
- 1996-01-17 EP EP96902156A patent/EP0805981A1/fr not_active Withdrawn
- 1996-01-17 WO PCT/US1996/000631 patent/WO1996023223A1/fr not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO1996023223A1 (fr) | 1996-08-01 |
| JPH10513259A (ja) | 1998-12-15 |
| MX9705713A (es) | 1997-10-31 |
| EP0805981A1 (fr) | 1997-11-12 |
| AU4657696A (en) | 1996-08-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Dead |