CA2215680C - Preparations en aerosol de prilocaine et d'hydrofluorocarbure - Google Patents

Preparations en aerosol de prilocaine et d'hydrofluorocarbure Download PDF

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Publication number
CA2215680C
CA2215680C CA002215680A CA2215680A CA2215680C CA 2215680 C CA2215680 C CA 2215680C CA 002215680 A CA002215680 A CA 002215680A CA 2215680 A CA2215680 A CA 2215680A CA 2215680 C CA2215680 C CA 2215680C
Authority
CA
Canada
Prior art keywords
prilocaine
base
liquid
hfc
prilocaine base
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002215680A
Other languages
English (en)
Other versions
CA2215680A1 (fr
Inventor
Richard A. Henry
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/405,930 external-priority patent/US5593661A/en
Priority claimed from US08/408,877 external-priority patent/US5534242A/en
Priority claimed from US08/435,812 external-priority patent/US5589156A/en
Application filed by Individual filed Critical Individual
Publication of CA2215680A1 publication Critical patent/CA2215680A1/fr
Application granted granted Critical
Publication of CA2215680C publication Critical patent/CA2215680C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A61K9/124—Aerosols; Foams characterised by the propellant

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Otolaryngology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La prilocaïne basique, sous forme liquide et sous forme de cristaux en microbâtonnets, peut être solubilisée dans des agents de propulsion aux hydrofluorocarbures pour donner un liquide huileux et stable. La prilocaïne basique peut être utilisée pour solubiliser, dans des agents de propulsion de ce genre, des médicaments additionnels qui, habituellement, ne sont pas solubles. L'association de prilocaïne basique et d'un agent de propulsion à l'hydrofluorocarbure peut être utilisée comme brouillard sous forme d'aérosol, pour produire une anesthésie topique.
CA002215680A 1995-03-17 1996-03-04 Preparations en aerosol de prilocaine et d'hydrofluorocarbure Expired - Lifetime CA2215680C (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US08/405,930 US5593661A (en) 1993-03-29 1995-03-17 Lidocaine aerosol anaesthetic
US08/405,930 1995-03-17
US08/408,877 1995-03-24
US08/408,877 US5534242A (en) 1994-05-02 1995-03-24 Lidocaine-vasoconstrictor aerosol preparation
US08/435,812 US5589156A (en) 1994-05-02 1995-05-05 Prilocaine and hydrofluourocarbon aerosol preparations
US08/435,812 1995-05-05
PCT/CA1996/000122 WO1996029066A1 (fr) 1995-03-17 1996-03-04 Preparations en aerosol de prilocaine et d'hydrofluorocarbure

Publications (2)

Publication Number Publication Date
CA2215680A1 CA2215680A1 (fr) 1996-09-26
CA2215680C true CA2215680C (fr) 2006-12-12

Family

ID=37561074

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002215680A Expired - Lifetime CA2215680C (fr) 1995-03-17 1996-03-04 Preparations en aerosol de prilocaine et d'hydrofluorocarbure

Country Status (1)

Country Link
CA (1) CA2215680C (fr)

Also Published As

Publication number Publication date
CA2215680A1 (fr) 1996-09-26

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Effective date: 20160304