CA2215748C - Procede et appareil de lyophilisation - Google Patents
Procede et appareil de lyophilisation Download PDFInfo
- Publication number
- CA2215748C CA2215748C CA002215748A CA2215748A CA2215748C CA 2215748 C CA2215748 C CA 2215748C CA 002215748 A CA002215748 A CA 002215748A CA 2215748 A CA2215748 A CA 2215748A CA 2215748 C CA2215748 C CA 2215748C
- Authority
- CA
- Canada
- Prior art keywords
- vessels
- vessel
- freezing
- magazines
- racks
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000000034 method Methods 0.000 title claims abstract description 102
- 230000008569 process Effects 0.000 title claims abstract description 95
- 238000004108 freeze drying Methods 0.000 title claims abstract description 47
- 238000007710 freezing Methods 0.000 claims abstract description 79
- 230000008014 freezing Effects 0.000 claims abstract description 78
- 238000010438 heat treatment Methods 0.000 claims abstract description 71
- 239000000463 material Substances 0.000 claims abstract description 71
- 238000001035 drying Methods 0.000 claims abstract description 57
- 238000011049 filling Methods 0.000 claims description 43
- 239000011344 liquid material Substances 0.000 claims description 39
- 239000007788 liquid Substances 0.000 claims description 27
- 239000007789 gas Substances 0.000 claims description 23
- 210000003739 neck Anatomy 0.000 claims description 20
- 238000001291 vacuum drying Methods 0.000 claims description 18
- 238000005406 washing Methods 0.000 claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 229940079593 drug Drugs 0.000 claims description 9
- 239000003814 drug Substances 0.000 claims description 9
- 230000001954 sterilising effect Effects 0.000 claims description 8
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 7
- 230000009471 action Effects 0.000 claims description 5
- 238000011068 loading method Methods 0.000 claims description 5
- 238000005303 weighing Methods 0.000 claims description 4
- 238000010924 continuous production Methods 0.000 claims description 3
- 229910001873 dinitrogen Inorganic materials 0.000 claims description 3
- 230000000284 resting effect Effects 0.000 claims description 2
- GNFTZDOKVXKIBK-UHFFFAOYSA-N 3-(2-methoxyethoxy)benzohydrazide Chemical compound COCCOC1=CC=CC(C(=O)NN)=C1 GNFTZDOKVXKIBK-UHFFFAOYSA-N 0.000 claims 1
- 239000011257 shell material Substances 0.000 description 64
- 239000000047 product Substances 0.000 description 30
- 239000002245 particle Substances 0.000 description 13
- 238000012546 transfer Methods 0.000 description 12
- 238000004519 manufacturing process Methods 0.000 description 8
- 238000009987 spinning Methods 0.000 description 7
- 238000011109 contamination Methods 0.000 description 6
- 238000005096 rolling process Methods 0.000 description 6
- 230000008901 benefit Effects 0.000 description 5
- 238000013461 design Methods 0.000 description 5
- 238000009413 insulation Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 3
- 230000004888 barrier function Effects 0.000 description 3
- 239000002775 capsule Substances 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 239000007900 aqueous suspension Substances 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 239000002826 coolant Substances 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 238000010981 drying operation Methods 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 230000036512 infertility Effects 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 230000037361 pathway Effects 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 229940127557 pharmaceutical product Drugs 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000010257 thawing Methods 0.000 description 2
- 230000000472 traumatic effect Effects 0.000 description 2
- 230000007306 turnover Effects 0.000 description 2
- 229960005486 vaccine Drugs 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 239000004411 aluminium Substances 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 238000007743 anodising Methods 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 238000010923 batch production Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000002788 crimping Methods 0.000 description 1
- 230000005574 cross-species transmission Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000008846 dynamic interplay Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000005429 filling process Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 238000009421 internal insulation Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000010301 surface-oxidation reaction Methods 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 238000004804 winding Methods 0.000 description 1
Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B5/00—Drying solid materials or objects by processes not involving the application of heat
- F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
- F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Drying Of Solid Materials (AREA)
Abstract
Un procédé de lyophilisation comprend une étape de congélation pendant laquelle un flacon (1) tourne autour de son axe longitudinal à une vitesse qui n'est pas inférieure à celle requise pour maintenir, par la force centrifuge, le matériau aqueux à lyophiliser sous la forme d'une coque (7) sur les parois internes du flacon (1) . Ensuite, le produit à congeler est soumis à des conditions de congélation pour être congelé sous la forme de ladite coque (7). Selon un autre aspect de l'invention, le processus de lyophilisation comprend également l'étape consistant à sécher la coque de produit congelé (7), en dirigeant de la chaleur radialement vers l'intérieur, depuis un bloc chauffant (14), sur la coque (7) de produit congelé et en augmentant la température pendant un certain temps pour sécher la coque (7) de matériau congelé.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9505523.2 | 1995-03-18 | ||
| GBGB9505523.2A GB9505523D0 (en) | 1995-03-18 | 1995-03-18 | Lyophilization process |
| PCT/GB1996/000597 WO1996029556A1 (fr) | 1995-03-18 | 1996-03-14 | Procede et appareil de lyophilisation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2215748A1 CA2215748A1 (fr) | 1996-09-26 |
| CA2215748C true CA2215748C (fr) | 2007-08-14 |
Family
ID=38434449
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002215748A Expired - Fee Related CA2215748C (fr) | 1995-03-18 | 1996-03-14 | Procede et appareil de lyophilisation |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2215748C (fr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3714226A4 (fr) * | 2017-11-22 | 2021-03-03 | IMA Life North America Inc. | Lyophilisation par pulvérisation sur un substrat |
| CN118833884B (zh) * | 2024-06-28 | 2025-11-25 | 金华瑞森包装有限公司 | 一种应用于印刷机上的污水处理装置 |
| CN119197046B (zh) * | 2024-07-10 | 2025-11-14 | 天津科技大学 | 单位剂量灌装的药品旋转冷冻干燥装置 |
-
1996
- 1996-03-14 CA CA002215748A patent/CA2215748C/fr not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2215748A1 (fr) | 1996-09-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0812411B1 (fr) | Procede et appareil de lyophilisation | |
| JP7295032B2 (ja) | 凍結乾燥方法および関連製品 | |
| EP3222952B1 (fr) | Procédé et système pour lyophiliser des compositions injectables, en particulier des compositions pharmaceutiques | |
| US5129162A (en) | Method and apparatus for loading and unloading containers from freeze-drying equipment | |
| US20230152036A1 (en) | Loading system for a freeze dryer, freeze-drying system, and corresponding method | |
| WO1992021143A1 (fr) | Module de traitement de plaquettes semi-conductrices | |
| CN105452791A (zh) | 提供内联灭菌冷冻干燥容纳在手推车托盘中产品的方法、用于执行该方法的系统和对该方法的使用 | |
| JP3904342B2 (ja) | 凍結真空乾燥装置 | |
| CA2215748C (fr) | Procede et appareil de lyophilisation | |
| MXPA97007083A (en) | Drying process and apparatus by congelac | |
| US20100251560A1 (en) | Holder | |
| US2645557A (en) | Sterilizing apparatus and method | |
| EP3145326B1 (fr) | Appareil de traitement thermique d'emballages alimentaires comprenant des supports de produit avec manipulation d'emballage positive | |
| JPH08215289A (ja) | ビンの表面及び内溶液除菌装置 | |
| US20250060159A1 (en) | Device and method for freeze-dryng liquid-containing composition | |
| NL2030238B1 (en) | Device and method for freeze-drying liquid-containing composition | |
| NL2030240B1 (en) | Device and method for freeze-drying liquid-containing composition | |
| NL2030242B1 (en) | Device and method for freeze-drying liquid-containing composition | |
| CN212778565U (zh) | 一种多肽的冻干设备 | |
| CA2566014A1 (fr) | Appareil pour congelation en coquille d'un contenu liquide dans un recipient | |
| JPS6334480A (ja) | 凍結乾燥方法及びその装置 | |
| JPS609451B2 (ja) | 加熱殺菌方法およびその装置 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20150316 |