CA2216564A1 - Inhibiteurs de farnesyl-proteine transferase - Google Patents

Inhibiteurs de farnesyl-proteine transferase Download PDF

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Publication number
CA2216564A1
CA2216564A1 CA002216564A CA2216564A CA2216564A1 CA 2216564 A1 CA2216564 A1 CA 2216564A1 CA 002216564 A CA002216564 A CA 002216564A CA 2216564 A CA2216564 A CA 2216564A CA 2216564 A1 CA2216564 A1 CA 2216564A1
Authority
CA
Canada
Prior art keywords
hydrogen
alkyl
aryl
alkenyl
r10oc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002216564A
Other languages
English (en)
Inventor
Terrence M. Ciccarone
Theresa M. Williams
Suzanne C. Mactough
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/412,830 external-priority patent/US5534537A/en
Priority claimed from US08/413,137 external-priority patent/US5578629A/en
Application filed by Individual filed Critical Individual
Publication of CA2216564A1 publication Critical patent/CA2216564A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention porte sur des composés peptidomimétiques comportant une fraction aminoalkylbenzamide adéquatement substituée. Ces composés instantanés inhibent la farnésyl-protéine transférase et la farnésylation de certaines protéines. De plus, ces inhibiteurs instantanés de farnésyl-protéine transférase différent de ceux préalablement décrits en ce qu'ils ne présentent pas de fraction thiol. Cette absence de thiol offre des avantages uniques en terme de comportement pharacocinétique amélioré chez l'animal, de prévention des réactions chimiques liées au thiol telles que la rapidité d'auto-oxydation ou la formation de disulfures avec des thiols endogènes, et une toxicité systémique réduite. L'invention porte également sur des compositions chimiothérapeutiques contenant lesdits inhibiteurs de farnésyl-protéine transférase et leurs procédés de production.
CA002216564A 1995-03-29 1996-03-25 Inhibiteurs de farnesyl-proteine transferase Abandoned CA2216564A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US413,137 1989-09-27
US412,830 1995-03-29
US08/412,830 US5534537A (en) 1995-03-29 1995-03-29 Prodrugs of inhibitors of farnesyl-protein transferase
US08/413,137 US5578629A (en) 1995-03-29 1995-03-29 Benzamide-containing inhibitors of farnesyl-protein transferase

Publications (1)

Publication Number Publication Date
CA2216564A1 true CA2216564A1 (fr) 1996-10-03

Family

ID=27021935

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002216564A Abandoned CA2216564A1 (fr) 1995-03-29 1996-03-25 Inhibiteurs de farnesyl-proteine transferase

Country Status (5)

Country Link
EP (1) EP0817630A4 (fr)
JP (1) JPH11503419A (fr)
AU (1) AU706008B2 (fr)
CA (1) CA2216564A1 (fr)
WO (1) WO1996030015A1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6693123B2 (en) 1995-11-06 2004-02-17 University Of Pittsburgh Inhibitors of protein isoprenyl transferases
US6310095B1 (en) 1995-11-06 2001-10-30 University Of Pittsburgh Inhibitors of protein isoprenyl transferases
US6221865B1 (en) 1995-11-06 2001-04-24 University Of Pittsburgh Inhibitors of protein isoprenyl transferases
US6204293B1 (en) 1995-11-06 2001-03-20 University Of Pittsburgh Inhibitors of protein isoprenyl transferases
AU703203B2 (en) * 1996-01-30 1999-03-18 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
AU717298B2 (en) * 1996-04-03 2000-03-23 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
EP0891335A4 (fr) * 1996-04-03 2001-08-16 Merck & Co Inc Inhibiteurs de transferase de farnesyl-proteine
DE19613691A1 (de) * 1996-04-05 1997-10-09 Boehringer Ingelheim Int Arzneimittel für die Behandlung von Tumorerkrankungen
AU7371998A (en) * 1997-05-07 1998-11-27 University Of Pittsburgh Inhibitors of protein isoprenyl transferases
FR2766819B1 (fr) * 1997-07-31 1999-10-29 Pf Medicament Nouvelles sulfonamides derivees d'anilines substituees utiles comme medicaments
AU9452998A (en) 1997-10-22 1999-05-10 Zeneca Limited Imidazole derivatives and their use as farnesyl protein transferase inhibit ors
US6342765B1 (en) 1997-10-22 2002-01-29 Astrazeneca Uk Limited Imidazole derivatives and their use as farnesyl protein transferase inhibitors
AU1872900A (en) 1998-12-23 2000-07-31 Astrazeneca Ab Chemical compounds
GB9930318D0 (en) 1999-12-22 2000-02-09 Zeneca Ltd Novel compounds
HN2001000008A (es) * 2000-01-21 2003-12-11 Inc Agouron Pharmaceuticals Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo
EP1846411A4 (fr) 2005-01-25 2010-08-04 Glaxo Group Ltd Agents antibacteriens

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8827308D0 (en) * 1988-11-23 1988-12-29 British Bio Technology Compounds

Also Published As

Publication number Publication date
EP0817630A1 (fr) 1998-01-14
AU5370196A (en) 1996-10-16
JPH11503419A (ja) 1999-03-26
AU706008B2 (en) 1999-06-03
WO1996030015A1 (fr) 1996-10-03
EP0817630A4 (fr) 1999-01-27

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Legal Events

Date Code Title Description
FZDE Dead