CA2217030C - Derives d'acide succinique inhibiteurs de protease - Google Patents
Derives d'acide succinique inhibiteurs de protease Download PDFInfo
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- CA2217030C CA2217030C CA002217030A CA2217030A CA2217030C CA 2217030 C CA2217030 C CA 2217030C CA 002217030 A CA002217030 A CA 002217030A CA 2217030 A CA2217030 A CA 2217030A CA 2217030 C CA2217030 C CA 2217030C
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- Prior art keywords
- phenyl
- amino
- compound
- lower alkyl
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000005843 halogen group Chemical group 0.000 claims description 30
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- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 claims description 10
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- LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 description 1
- 235000015523 tannic acid Nutrition 0.000 description 1
- 229940033123 tannic acid Drugs 0.000 description 1
- 229920002258 tannic acid Polymers 0.000 description 1
- CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
- 229930192474 thiophene Natural products 0.000 description 1
- 229960002898 threonine Drugs 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- YFNGWGVTFYSJHE-UHFFFAOYSA-K trisodium;phosphonoformate Chemical compound [Na+].[Na+].[Na+].OP(O)(=O)C([O-])=O.OP(O)(=O)C([O-])=O.OP(O)(=O)C([O-])=O YFNGWGVTFYSJHE-UHFFFAOYSA-K 0.000 description 1
- 238000001665 trituration Methods 0.000 description 1
- 229960004295 valine Drugs 0.000 description 1
- 125000002987 valine group Chemical group [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 210000002845 virion Anatomy 0.000 description 1
- 239000012224 working solution Substances 0.000 description 1
- 229960000523 zalcitabine Drugs 0.000 description 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La présente invention décrit des composés qui inhibent l'activité de protéase du virus de l'immunodéficience humaine (VIH) et inhibent la répétition de VIH dans les cellules humaines. Par conséquent, ces composés sont indiqués dans le traitement des infections VIH. Ces composés peuvent être représentés par la formule (I), dans laquelle X est un groupe en fin de chaîne, un aryloxycarbonyle, un alkanoyle ou un carbamoyle arylalkyle; A est absent ou représente un acide aminé ou un acide aminé dérivé; l'un des éléments R<1> ou R<2> représente hydrogène tandis que l'autre représente alkyle ou R<1> et R<2> sont unis pour former un cyclohexane; Q représente hydrogène, hydroxy, halo ou alkyle inférieur; et Y est un groupe de fin de chaîne, par exemple un alkylamino, alkoxy ou un anilino facultativement substitué.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/416,239 | 1995-04-04 | ||
| US08/416,239 US5545640A (en) | 1995-04-04 | 1995-04-04 | Protease inhibiting succinic acid derivatives |
| PCT/CA1996/000181 WO1996031527A1 (fr) | 1995-04-04 | 1996-03-27 | Derives d'acide succinique inhibiteurs de protease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2217030A1 CA2217030A1 (fr) | 1996-10-10 |
| CA2217030C true CA2217030C (fr) | 2006-04-11 |
Family
ID=36178141
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002217030A Expired - Fee Related CA2217030C (fr) | 1995-04-04 | 1996-03-27 | Derives d'acide succinique inhibiteurs de protease |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2217030C (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12281141B2 (en) | 2017-06-09 | 2025-04-22 | Chugai Seiyaku Kabushiki Kaisha | Method for synthesizing peptide containing N-substituted amino acid |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7568510B2 (ja) * | 2018-11-30 | 2024-10-16 | 中外製薬株式会社 | ペプチド化合物、またはアミド化合物の脱保護法および固相反応における脱樹脂方法、並びにペプチド化合物の製造方法 |
-
1996
- 1996-03-27 CA CA002217030A patent/CA2217030C/fr not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12281141B2 (en) | 2017-06-09 | 2025-04-22 | Chugai Seiyaku Kabushiki Kaisha | Method for synthesizing peptide containing N-substituted amino acid |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2217030A1 (fr) | 1996-10-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |