CA2224799A1 - A human edg-2 receptor homolog - Google Patents

A human edg-2 receptor homolog Download PDF

Info

Publication number: CA2224799A1
Authority: CA; Canada
Prior art keywords: hedg; polypeptide; leu; ser; ile
Prior art date: 1995-06-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002224799A

Other languages

English (en)

French (fr)

Inventor

Olga Bandman

Karl J. Guegler

Janice Au-Young

Jeffrey J. Seilhamer

Roger Coleman

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Incyte Corp

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-20

Filing date

1996-06-20

Publication date

1997-01-09

1996-06-20 Application filed by Individual filed Critical Individual

1997-01-09 Publication of CA2224799A1 publication Critical patent/CA2224799A1/en

Status Abandoned legal-status Critical Current

Links

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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Gastroenterology & Hepatology (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Rheumatology (AREA)
Public Health (AREA)
Pain & Pain Management (AREA)
Cell Biology (AREA)
Immunology (AREA)
Toxicology (AREA)
Zoology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

CA002224799A 1995-06-20 1996-06-20 A human edg-2 receptor homolog Abandoned CA2224799A1 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date
US35295P	1995-06-20	1995-06-20
US56781795A	1995-12-06	1995-12-06
US60/000,352		1995-12-06
US08/567,817		1995-12-06

Publications (1)

Publication Number	Publication Date
CA2224799A1 true CA2224799A1 (en)	1997-01-09

Family

ID=26667516

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002224799A Abandoned CA2224799A1 (en)	1995-06-20	1996-06-20	A human edg-2 receptor homolog

Country Status (5)

Country	Link
EP (1)	EP0840787A2 (de)
JP (1)	JPH11508135A (de)
AU (1)	AU718269B2 (de)
CA (1)	CA2224799A1 (de)
WO (1)	WO1997000952A2 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2759375B1 (fr) *	1997-02-13	1999-04-30	Inst Nat Sante Rech Med	Polypeptide a activite de recepteur ob25 specifique des cellules myelinisantes chez le rat, application au criblage de medicaments et medicaments
FR2759374B1 (fr) *	1997-02-13	1999-04-30	Inst Nat Sante Rech Med	Polypeptide a activite de recepteur ob25 specifique des cellules myelinisantes chez le rat, application au criblage de medicaments et medicaments
US5912144A (en) *	1997-04-24	1999-06-15	Incyte Pharmaceuticals, Inc.	Edg-1-receptor homolog
US6020158A (en) *	1997-05-22	2000-02-01	Allelix Biopharmaceuticals, Inc.	Isolated polynucleotide for novel G-protein coupled receptor
US6485922B1 (en)	1997-10-10	2002-11-26	Atairgin Technologies, Inc.	Methods for detecting compounds which modulate the activity of an LPA receptor
WO1999019513A2 (en) *	1997-10-10	1999-04-22	Lxr Biotechnology, Inc.	Methods for detecting compounds which modulate the activity of an lpa receptor
DE69825629T2 (de)	1997-12-30	2005-08-11	Nps Allelix Corp., Mississauga	Säugertier edg-7 rezeptor homologen
AU1865499A (en)	1997-12-30	1999-07-26	Allelix Biopharmaceuticals Inc.	Identification of lysolipid receptors involved in inflammatory response
EP1053323A2 (de) *	1998-02-12	2000-11-22	Incyte Pharmaceuticals, Inc.	Menschliche rezeptorproteine
AU5575299A (en) *	1998-08-19	2000-03-14	Millennium Pharmaceuticals, Inc.	14274 receptor, a g-protein coupled receptor related to the edg receptor family
US6812335B1 (en)	1999-03-23	2004-11-02	The Regents Of The University Of California	Human polypeptide receptors for lysophospholipids and sphingolipids and nucleic acids encoding the same
AU2002246680A1 (en)	2000-12-22	2002-07-30	University Of South Florida	Sphingosine 1-phosphate receptor gene, sppr
AU2003278165A1 (en) *	2002-11-13	2004-06-03	Bayer Healthcare Ag	Diagnostics and therapeutics for diseases associated with human endothelial differentiation, lysophosphatidic acid g-protein-coupled receptor 2 (edg2)
US20070003928A1 (en) *	2002-12-12	2007-01-04	Shuji Hinuma	Novel use of edg receptors
US20100239501A1 (en) *	2007-06-12	2010-09-23	Riken	Gene sensitive to bone/joint disease and use thereof

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Publication number	Priority date	Publication date	Assignee	Title
AU7686891A (en) *	1990-04-05	1991-10-30	American National Red Cross, The	A protein family related to immediate-early protein expressed by human endothelial cells during differentiation

1996
- 1996-06-20 EP EP96945463A patent/EP0840787A2/de not_active Withdrawn
- 1996-06-20 WO PCT/US1996/010618 patent/WO1997000952A2/en not_active Ceased
- 1996-06-20 CA CA002224799A patent/CA2224799A1/en not_active Abandoned
- 1996-06-20 JP JP9503937A patent/JPH11508135A/ja active Pending
- 1996-06-20 AU AU63886/96A patent/AU718269B2/en not_active Ceased

Also Published As

Publication number	Publication date
EP0840787A2 (de)	1998-05-13
AU6388696A (en)	1997-01-22
WO1997000952A3 (en)	1997-03-20
WO1997000952A2 (en)	1997-01-09
AU718269B2 (en)	2000-04-13
JPH11508135A (ja)	1999-07-21
MX9710409A (es)	1998-07-31

Legal Events

Date	Code	Title	Description
2001-06-20	FZDE	Dead

Publication	Publication Date	Title
CA2224799A1 (en)	1997-01-09	A human edg-2 receptor homolog
AU721194B2 (en)	2000-06-29	Thrombin receptor homolog
CA2207262A1 (en)	1996-06-13	A novel chemokine expressed in inflamed adenoid, its production and uses
AU718311B2 (en)	2000-04-13	A C5a-like seven transmembrane receptor
MXPA97009338A (en)	1998-02-01	Transmembrane-seven type receiver
CA2216858A1 (en)	1996-10-17	Phospholipase c homolog
US6534275B1 (en)	2003-03-18	Cellubrevin homologs
US5780268A (en)	1998-07-14	Chemokine expressed in a mixed lymphocyte reaction
AU723640B2 (en)	2000-08-31	A human map kinase homolog
US7179898B1 (en)	2007-02-20	Human vanilloid receptor-like receptor
CA2264544A1 (en)	1998-04-02	Snrnp sm proteins
CA2264542A1 (en)	1998-03-26	Human gtp binding protein gamma-3
MXPA97010409A (en)	1998-11-09	Homologo de receptor de edg-2 hum
WO1999036523A1 (en)	1999-07-22	A gene similar to rat golgi v-snare (gos-28) (cblalg01)
WO2003045999A2 (en)	2003-06-05	Human vanilloid receptor protein and polynucleotide sequence encoding same
MXPA97009746A (en)	1998-11-09	Homologo de receptor de tromb
MXPA97007852A (en)	1998-01-01	Homologo de fosfolipas
CA2232814A1 (en)	1998-11-27	Novel compounds