CA2226962A1 - Utilisation d'agents liants a cd47 et ces ligands pour le traitement ou prophylaxie de maladies inflammatoire, autoimmunitaire et allergique et pour le traitement de rejet de greffons - Google Patents

Utilisation d'agents liants a cd47 et ces ligands pour le traitement ou prophylaxie de maladies inflammatoire, autoimmunitaire et allergique et pour le traitement de rejet de greffons Download PDF

Info

Publication number
CA2226962A1
CA2226962A1 CA002226962A CA2226962A CA2226962A1 CA 2226962 A1 CA2226962 A1 CA 2226962A1 CA 002226962 A CA002226962 A CA 002226962A CA 2226962 A CA2226962 A CA 2226962A CA 2226962 A1 CA2226962 A1 CA 2226962A1
Authority
CA
Canada
Prior art keywords
cells
mabs
mab
cell
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002226962A
Other languages
English (en)
Inventor
Marie Sarfati
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CA002226962A priority Critical patent/CA2226962A1/fr
Priority to PCT/CA1999/000140 priority patent/WO1999040940A1/fr
Priority to AU25084/99A priority patent/AU2508499A/en
Publication of CA2226962A1 publication Critical patent/CA2226962A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Transplantation (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002226962A 1998-02-16 1998-02-16 Utilisation d'agents liants a cd47 et ces ligands pour le traitement ou prophylaxie de maladies inflammatoire, autoimmunitaire et allergique et pour le traitement de rejet de greffons Abandoned CA2226962A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002226962A CA2226962A1 (fr) 1998-02-16 1998-02-16 Utilisation d'agents liants a cd47 et ces ligands pour le traitement ou prophylaxie de maladies inflammatoire, autoimmunitaire et allergique et pour le traitement de rejet de greffons
PCT/CA1999/000140 WO1999040940A1 (fr) 1998-02-16 1999-02-16 Ligands de l'antigene cd47, agents le fixant et leur emploi
AU25084/99A AU2508499A (en) 1998-02-16 1999-02-16 Ligands of the cd47 antigen, agents binding the ligands of the cd47 antigen and uses thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA002226962A CA2226962A1 (fr) 1998-02-16 1998-02-16 Utilisation d'agents liants a cd47 et ces ligands pour le traitement ou prophylaxie de maladies inflammatoire, autoimmunitaire et allergique et pour le traitement de rejet de greffons

Publications (1)

Publication Number Publication Date
CA2226962A1 true CA2226962A1 (fr) 1999-08-16

Family

ID=4161989

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002226962A Abandoned CA2226962A1 (fr) 1998-02-16 1998-02-16 Utilisation d'agents liants a cd47 et ces ligands pour le traitement ou prophylaxie de maladies inflammatoire, autoimmunitaire et allergique et pour le traitement de rejet de greffons

Country Status (3)

Country Link
AU (1) AU2508499A (fr)
CA (1) CA2226962A1 (fr)
WO (1) WO1999040940A1 (fr)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000053634A1 (fr) * 1999-03-10 2000-09-14 Chugai Seiyaku Kabushiki Kaisha Fv monocatenaire induisant l'apoptose
EP1048299A1 (fr) * 1999-04-28 2000-11-02 Faculteit der Geneeskunde van de Vrije Universiteit Procédé pour l'inhibition du fonctionemment cellulaire dans la therapie antiinflammatoire et anticancéreuse
DE19952960A1 (de) 1999-11-03 2001-05-10 Mark Andre Freyberg Verfahren zur Identifizierung von anti-apoptotisch wirksamen Verbindungen
WO2001040307A1 (fr) * 1999-11-30 2001-06-07 Eberhard-Karls-Universität Tübingen Universitätsklinikum Anticorps diriges contre les proteines regulatrices de signal
GB9930706D0 (en) * 1999-12-24 2000-02-16 Medical Res Council Composition for inhibiting macrophage activity
TWI241345B (en) * 2000-03-10 2005-10-11 Chugai Pharmaceutical Co Ltd Apoptosis inducing polypeptide
DE10109136A1 (de) * 2001-02-26 2002-09-12 Cytotools Gmbh Mittel, die die Apoptose bei an der Wundheilung beteiligten Zellen inhibieren
US8613922B2 (en) 2003-04-24 2013-12-24 The University Of North Carolina At Chapel Hill Methods for inhibiting diabetic retinopathy with an antibody against integrin associated protein (IAP)
US20040213792A1 (en) * 2003-04-24 2004-10-28 Clemmons David R. Method for inhibiting cellular activation by insulin-like growth factor-1
US8377448B2 (en) 2006-05-15 2013-02-19 The Board Of Trustees Of The Leland Standford Junior University CD47 related compositions and methods for treating immunological diseases and disorders
US20080131431A1 (en) * 2006-05-15 2008-06-05 Viral Logic Systems Technology Corp. CD47 related compositions and methods for treating immunological diseases and disorders
AU2014201936B2 (en) * 2006-10-06 2016-07-07 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Prevention of tissue ischemia, related methods and compositions
AU2007319576B2 (en) 2006-10-06 2014-01-16 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Prevention of tissue ischemia, related methods and compositions
AU2016238894B2 (en) * 2006-10-06 2017-11-09 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Prevention of tissue ischemia, related methods and compositions
EP2573112A1 (fr) * 2007-10-11 2013-03-27 The Hospital For Sick Children Modulation dýune interaction sirpa-cd47 pour augmenter la préparation de cellules souches hématopoïétiques humaines et composés correspondants
PT2242512T (pt) 2008-01-15 2016-07-18 Univ Leland Stanford Junior Métodos para manipular a fagocitose mediada por cd47
US11072655B2 (en) 2008-01-15 2021-07-27 The Board Of Trustees Of The Leland Stanford Junior University Markers of acute myeloid leukemia stem cells
CA3108119C (fr) 2008-01-15 2024-01-16 The Board Of Trustees Of The Leland Stanford Junior University Marqueurs des cellules souches de la leucemie myeloide aigue
EP2111869A1 (fr) 2008-04-23 2009-10-28 Stichting Sanquin Bloedvoorziening Compositions et procédés pour renforcer le système immunitaire
CN102257001A (zh) * 2008-12-19 2011-11-23 诺瓦提斯公司 治疗自体免疫和炎性病症的可溶性多肽
EP4311863A3 (fr) * 2009-05-15 2024-04-10 University Health Network Compositions et méthodes de traitement de cancers hématologiques ciblant l'interaction sirp alpha-cd47
US8758750B2 (en) * 2009-09-15 2014-06-24 The Board Of Trustees Of The Leland Stanford Junior University Synergistic anti-CD47 therapy for hematologic cancers
US9221908B2 (en) 2012-12-12 2015-12-29 Vasculox, Inc. Therapeutic CD47 antibodies
RU2015122228A (ru) 2012-12-12 2017-01-19 Васкулокс Инк. Терапевтические антитела к CD47
HRP20192013T1 (hr) 2012-12-17 2020-02-07 Trillium Therapeutics Inc. Liječenje cd47+ oboljelih stanica sa sirp alfa-fc fuzijama
WO2014160183A1 (fr) * 2013-03-13 2014-10-02 The United States Of America,As Represented By The Secretary,Department Of Health And Human Services Procédés de modulation de la cytotoxicité chimiothérapeutique
EP3046627B1 (fr) * 2013-09-18 2019-10-23 The Board of Trustees of the Leland Stanford Junior University Modulation des voies de l'efferocytose pour le traitement d'une maladie athérosclérotique
WO2017027422A1 (fr) 2015-08-07 2017-02-16 Alexo Therapeutics Inc. Constructions contenant un domaine sirp-alpha ou un variant de celui-ci
WO2017049251A2 (fr) 2015-09-18 2017-03-23 Tioma Therapeutics, Inc. Anticorps cd47 thérapeutiques
HK1257309A1 (zh) 2015-09-21 2019-10-18 Erasmus University Medical Center 抗-cd47抗体及使用方法
ES2796378T3 (es) 2016-01-11 2020-11-26 Forty Seven Inc Anticuerpos monoclonales anti-cd47 humanizados, de ratón o químicos
WO2017194586A1 (fr) * 2016-05-10 2017-11-16 Université Pierre Et Marie Curie - Paris 6 (Upmc) Agents activant le récepteur cd47 et leur utilisation dans le traitement de l'inflammation
JOP20190009A1 (ar) 2016-09-21 2019-01-27 Alx Oncology Inc أجسام مضادة ضد بروتين ألفا منظم للإشارات وطرق استخدامها
EP3411071A4 (fr) 2016-10-20 2019-08-28 I-Mab Nouveaux anticorps monoclonaux anti-cd 47 et leurs utilisations
WO2018075960A1 (fr) 2016-10-21 2018-04-26 Tioma Therapeutics, Inc. Anticorps cd47 thérapeutiques
PL3658589T3 (pl) 2017-07-26 2024-03-18 Forty Seven, Inc. Przeciwciała anty-sirp-alfa i powiązane sposoby
EA039662B1 (ru) 2017-10-03 2022-02-24 Закрытое Акционерное Общество "Биокад" Антитела, специфичные к cd47 и pd-l1
EP3541941A4 (fr) * 2017-11-10 2019-12-25 I-Mab Biopharma US Limited Protéines de fusion contenant des anticorps anti-cd47 et des cytokines
TWI831759B (zh) 2017-12-01 2024-02-11 美商思進公司 Cd47抗體及其用於治療癌症之用途
ES2927305T3 (es) 2018-02-12 2022-11-04 Forty Seven Inc Régimen contra el cáncer usando anticuerpos anti-CD47 y anti-CD20
EP3768314A4 (fr) 2018-03-21 2022-01-05 ALX Oncology Inc. Anticorps contre la protéine régulatrice de signal alpha et procédés d'utilisation
KR20220044904A (ko) 2019-05-31 2022-04-12 알렉소 온콜로지 인크. 면역 관문 억제제와 병용하는 sirp 알파 fc 융합으로 암을 치료하는 방법
AU2020315598B2 (en) 2019-07-16 2024-12-12 Gilead Sciences, Inc. HIV vaccines and methods of making and using
KR102902719B1 (ko) 2019-10-18 2025-12-24 포티 세븐, 엘엘씨 골수이형성 증후군 및 급성 골수성 백혈병을 치료하기 위한 조합 치료
CA3153636A1 (fr) 2019-10-31 2021-05-06 Forty Seven, Inc. Traitement d'un cancer du sang base sur une therapie anti-cd47 et anti-cd20
CN114845710A (zh) 2019-11-27 2022-08-02 Alx肿瘤生物技术公司 用于治疗癌症的组合疗法
EP4445902A3 (fr) 2019-12-24 2024-12-18 Carna Biosciences, Inc. Composés modulant la diacylglycérol kinase
CN117964757A (zh) 2020-02-14 2024-05-03 吉利德科学公司 与ccr8结合的抗体和融合蛋白及其用途
WO2021191870A1 (fr) 2020-03-27 2021-09-30 Dcprime B.V. Utilisation ex vivo de cellules modifiées d'origine leucémique pour améliorer l'efficacité d'une thérapie cellulaire adoptive
KR20230033647A (ko) 2020-06-30 2023-03-08 멘두스 비.브이. 난소암 백신에서 백혈병 유래 세포의 용도
EP4190813A4 (fr) * 2020-07-31 2025-02-12 Bio-Thera Solutions, Ltd. Anticorps contre le cd47 et son application
WO2022190058A1 (fr) 2021-03-12 2022-09-15 Dcprime B.V. Méthodes de vaccination et utilisation d'un blocage de cd47
TW202302145A (zh) 2021-04-14 2023-01-16 美商基利科學股份有限公司 CD47/SIRPα結合及NEDD8活化酶E1調節次單元之共抑制以用於治療癌症
BR112023022774A2 (pt) 2021-05-13 2024-01-02 Alx Oncology Inc Terapias de combinação para tratamento de câncer
WO2022271659A1 (fr) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Composés modulant les diacylglycérol kinases
EP4359415A1 (fr) 2021-06-23 2024-05-01 Gilead Sciences, Inc. Composés modulant les diacylglycérol kinases
WO2022271650A1 (fr) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Composés de modulation de la diacylglycérol kinase
US11932634B2 (en) 2021-06-23 2024-03-19 Gilead Sciences, Inc. Diacylglycerol kinase modulating compounds
CN113501874B (zh) * 2021-08-09 2022-03-11 生工生物工程(上海)股份有限公司 一种抗人cd47蛋白的抗体、检测试剂盒及其应用
AU2022375782B2 (en) 2021-10-28 2026-02-26 Gilead Sciences, Inc. Pyridizin-3(2h)-one derivatives
AU2022376954B2 (en) 2021-10-29 2026-04-23 Gilead Sciences, Inc. Cd73 compounds
CA3237577A1 (fr) 2021-12-22 2023-06-29 Gilead Sciences, Inc. Agents de degradation des doigts de zinc de la famille ikaros et leurs utilisations
TW202340168A (zh) 2022-01-28 2023-10-16 美商基利科學股份有限公司 Parp7抑制劑
EP4493554A1 (fr) 2022-03-17 2025-01-22 Gilead Sciences, Inc. Agents de dégradation des doigts de zinc de la famille ikaros et leurs utilisations
WO2023183817A1 (fr) 2022-03-24 2023-09-28 Gilead Sciences, Inc. Polythérapie pour le traitement de cancers exprimant trop -2
TWI876305B (zh) 2022-04-05 2025-03-11 美商基利科學股份有限公司 用於治療結腸直腸癌之組合療法
CR20240451A (es) 2022-04-21 2024-12-04 Gilead Sciences Inc Compuestos de modulación de kras g12d
PE20250758A1 (es) 2022-07-01 2025-03-13 Gilead Sciences Inc Compuestos de cd73
KR20250036855A (ko) 2022-07-12 2025-03-14 길리애드 사이언시즈, 인코포레이티드 Hiv 면역원성 폴리펩타이드 및 백신, 및 이들의 용도
WO2024064668A1 (fr) 2022-09-21 2024-03-28 Gilead Sciences, Inc. POLYTHÉRAPIE ANTICANCÉREUSE PAR RAYONNEMENT IONISANT FOCAL ET PERTURBATION CD47/SIRPα
CN120225509A (zh) 2022-12-22 2025-06-27 吉利德科学公司 Prmt5抑制剂及其用途
AU2024252725A1 (en) 2023-04-11 2025-11-06 Gilead Sciences, Inc. Kras modulating compounds
PE20260121A1 (es) 2023-04-21 2026-01-16 Gilead Sciences Inc Inhibidores de prmt5 y usos de los mismos
AU2024306338A1 (en) 2023-06-30 2026-01-08 Gilead Sciences, Inc. Kras modulating compounds
KR20260046403A (ko) 2023-07-26 2026-04-07 길리애드 사이언시즈, 인코포레이티드 Parp7 저해제
WO2025024811A1 (fr) 2023-07-26 2025-01-30 Gilead Sciences, Inc. Inhibiteurs de parp7
AU2024337913A1 (en) 2023-09-08 2026-03-26 Gilead Sciences, Inc. Pyrimidine-containing polycyclic derivatives as kras g12d modulating compounds
US20250101042A1 (en) 2023-09-08 2025-03-27 Gilead Sciences, Inc. Kras g12d modulating compounds
US20250154172A1 (en) 2023-11-03 2025-05-15 Gilead Sciences, Inc. Prmt5 inhibitors and uses thereof
WO2025137640A1 (fr) 2023-12-22 2025-06-26 Gilead Sciences, Inc. Inhibiteurs azaspiro de wrn
WO2025245003A1 (fr) 2024-05-21 2025-11-27 Gilead Sciences, Inc. Inhibiteurs de prmt5 et leurs utilisations
WO2026039365A1 (fr) 2024-08-12 2026-02-19 Gilead Sciences, Inc. Composés de modulation de kras
WO2026089992A1 (fr) 2024-10-21 2026-04-30 Gilead Sciences, Inc. Inhibiteurs de prmt5 et leurs utilisations

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5057604A (en) * 1988-08-03 1991-10-15 Washington University Novel monoclonal antibodies
EP1069137A1 (fr) * 1990-09-24 2001-01-17 W.R. Grace & Co.-Conn. Peptides ayant une activité de type thrombospondine et leur utilisation thérapeutique
WO1994011739A1 (fr) * 1992-11-16 1994-05-26 Cymbus Bioscience Limited Diagnostic de troubles oculaires
WO1997027873A1 (fr) * 1996-01-30 1997-08-07 Brigham & Women's Hospital, Inc. Anticorps destines a moduler la transmigration des neutrophiles induite par cd47

Also Published As

Publication number Publication date
AU2508499A (en) 1999-08-30
WO1999040940A1 (fr) 1999-08-19

Similar Documents

Publication Publication Date Title
WO1999040940A1 (fr) Ligands de l'antigene cd47, agents le fixant et leur emploi
US20230146195A1 (en) Bcma binding molecules and methods of use thereof
Hatachi et al. CD4+ PD-1+ T cells accumulate as unique anergic cells in rheumatoid arthritis synovial fluid.
RU2759334C2 (ru) Антитела против siglec-15 и способы их применения
Cayabyab et al. CD40 preferentially costimulates activation of CD4+ T lymphocytes.
AU2019303033B2 (en) Antibody molecules
EP3204422B1 (fr) Anticorps humanisés anti-ox40 et utilisations desdits anticorps
US10975155B2 (en) CD40L-Fc fusion polypeptides and methods of use thereof
CA2738252C (fr) Anticorps anti-pd-1, pd-l1, et pd-l2 humains et leurs utilisations
Alegre et al. Effect of a single amino acid mutation on the activating and immunosuppressive properties of a" humanized" OKT3 monoclonal antibody
JP2022513778A (ja) キメラ抗原受容体及びt細胞受容体並びに使用方法
US20060002933A1 (en) Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies
JP2020500181A (ja) Bcma及びcd3に対する二重特異性抗体、及び多発性骨髄腫を治療するために併用して使用される免疫療法薬
WO2017178653A2 (fr) Nouveaux anticorps anti-sirpa et leurs applications thérapeutiques
CN111511766A (zh) 修饰的抗SIRPa抗体及其应用
JP2022169504A (ja) 新規な抗SIRPa抗体およびそれらの治療適用
JP5162239B2 (ja) mAbCL1−R2から得られる抗CD160特異的化合物の血管新生と免疫の用途
WO2014022758A1 (fr) Anticorps de liaison double à agent unique anti-pd-l1 et pd-l2 et procédés d'utilisation
EA031849B1 (ru) Антитела к ox40 и способы их применения
WO2018151817A2 (fr) Utilisation conjointe d'un anticorps anti-bcma et d'un récepteur de lymphocytes t lié à un anticorps (actr) en cancérothérapie et troubles liés aux lymphocytes b
WO2019128708A1 (fr) Anticorps isolé ou fragment de liaison à l'antigène de celui-ci et son utilisation dans le traitement de tumeurs
Genestier et al. Fas-independent apoptosis of activated T cells induced by antibodies to the HLA class I α1 domain
KR20250059415A (ko) B7-h3 항원-결합 분자
Knigge et al. The outer surface lipoprotein OspA of Borrelia burgdorferi provides co‐stimulatory signals to normal human peripheral CD4+ and CD8+ T lymphocytes
Galatiuc et al. Natural killer (NK) activity in human responders and nonresponders to stimulation by anti-CD16 antibodies

Legal Events

Date Code Title Description
FZDE Dead