CA2229316C - Derives de calcitriol et leurs utilisations - Google Patents

Derives de calcitriol et leurs utilisations Download PDF

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Publication number
CA2229316C
CA2229316C CA002229316A CA2229316A CA2229316C CA 2229316 C CA2229316 C CA 2229316C CA 002229316 A CA002229316 A CA 002229316A CA 2229316 A CA2229316 A CA 2229316A CA 2229316 C CA2229316 C CA 2229316C
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CA
Canada
Prior art keywords
group
vitamin
derivative
represent
use according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002229316A
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English (en)
Other versions
CA2229316A1 (fr
Inventor
Hector F. Deluca
Heinrich K. Schnoes
Zu Yun Cai
Mary E. Phelps
Connie M. Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
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Filing date
Publication date
Priority claimed from US08/531,403 external-priority patent/US5952317A/en
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Publication of CA2229316A1 publication Critical patent/CA2229316A1/fr
Application granted granted Critical
Publication of CA2229316C publication Critical patent/CA2229316C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention se rapporte à un procédé de traitement des maladies osseuses métaboliques telles que l'ostéoporose, ainsi que d'autres états pathologiques pouvant être traités avec des composés de la vitamine D, ce procédé consistant à administrer une quantité efficace d'un ou plusieurs composés modifiés de la vitamine D. Le composé modifié contient un noyau type de vitamine D, mais présentant des groupes hydrolysables in vivo à une ou plusieurs des positions de carbone 1, 3 et 25. Il est possible de réguler le temps de conversion à sa forme active du composé modifié, tel que le calcitriol, en vue d'obtenir une libération régulée du composé in vivo sur plusieurs heures, en changeant ou modifiant les groupes hydrolysables.
CA002229316A 1995-09-21 1996-09-20 Derives de calcitriol et leurs utilisations Expired - Fee Related CA2229316C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US53186795A 1995-09-21 1995-09-21
US08/531,867 1995-09-21
US08/531,403 US5952317A (en) 1995-09-21 1995-09-21 Calcitriol derivatives and their uses
US08/531,403 1995-09-21
PCT/US1996/015184 WO1997011053A1 (fr) 1995-09-21 1996-09-20 Derives de calcitriol et leurs utilisations

Publications (2)

Publication Number Publication Date
CA2229316A1 CA2229316A1 (fr) 1997-03-27
CA2229316C true CA2229316C (fr) 2005-04-12

Family

ID=27063537

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002229316A Expired - Fee Related CA2229316C (fr) 1995-09-21 1996-09-20 Derives de calcitriol et leurs utilisations

Country Status (9)

Country Link
EP (1) EP1021401A1 (fr)
JP (1) JP3372259B2 (fr)
KR (1) KR100327922B1 (fr)
AU (1) AU717238B2 (fr)
CA (1) CA2229316C (fr)
HU (1) HUP9802303A3 (fr)
NO (1) NO981282L (fr)
NZ (2) NZ501318A (fr)
WO (1) WO1997011053A1 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5795909A (en) 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
WO2001011986A1 (fr) * 1999-08-17 2001-02-22 Wisconsin Alumni Research Foundation Aliments pour animaux contenant des derives de calcitriol hydrolysables
KR100317935B1 (ko) * 1999-10-20 2001-12-22 유승필 대사성 골질환 치료용 약제조성물 및 이의 제조방법
US20020045606A1 (en) 1999-12-02 2002-04-18 Reddy Satyanarayana G. Esters of vitamin D3 and uses thereof
US20030195175A1 (en) * 2002-03-25 2003-10-16 Deluca Hector F. Use of carbon-2-modified-vitamin D analogs to induce the formation of new bone
JP2007525533A (ja) 2004-03-01 2007-09-06 ビオエクセル エスピーエー 間質性膀胱炎の治療方法、並びに関連化合物及び組成物
US20080293647A1 (en) 2004-11-12 2008-11-27 Luciano Adorini Combined Use Of Vitamin D Derivatives And Anti-Proliferative Agents For Treating Bladder Cancer
SI3095447T1 (sl) 2006-02-03 2022-02-28 Opko Renal, Llc Zdravljenje pomanjkanja vitamina D s 25-hidroksivitaminom D2 in 25-hidroksivitaminom D3
HUE037309T2 (hu) 2006-06-21 2018-08-28 Opko Ireland Global Holdings Ltd Terápia D-vitamin telítési szer alkalmazásával és D-vitamin hormon helyettesítõ szer
PT3335712T (pt) 2007-04-25 2025-10-23 Opko Renal Llc Método de tratamento e prevenção seguro e eficaz do hiperparatiroidismo secundário na doença renal crónica
DK2148684T3 (da) 2007-04-25 2013-04-22 Cytochroma Inc Fremgangsmåde til behandling af vitamin D-insufficiens og -deficiens
US8592401B2 (en) 2007-04-25 2013-11-26 Proventiv Therapeutics, Llc Methods and compounds for vitamin D therapy
PL2148661T3 (pl) 2007-04-25 2013-07-31 Cytochroma Inc Doustne kompozycje o kontrolowanym uwalnianiu zawierające związek będący witaminą D i woskowy nośnik
CN102046812A (zh) 2008-04-02 2011-05-04 赛特克罗公司 用于维生素d缺乏症和相关障碍的方法、组合物、用途和试剂盒
PT2552484T (pt) 2010-03-29 2020-04-03 Opko Ireland Global Holdings Ltd Métodos e composições para redução dos níveis de parafróides
KR101847947B1 (ko) 2013-03-15 2018-05-28 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 안정화되고 변형된 비타민 ｄ 방출 제형
US10220047B2 (en) 2014-08-07 2019-03-05 Opko Ireland Global Holdings, Ltd. Adjunctive therapy with 25-hydroxyvitamin D and articles therefor
MY198547A (en) 2016-03-28 2023-09-04 Opko Ireland Global Holdings Ltd Methods of vitamin d treatment
KR101983654B1 (ko) * 2018-07-24 2019-05-29 한국과학기술원 Cfc 증후군 환자의 발달 저해를 완화할 수 있는 치료용 조성물
CN114656413B (zh) * 2022-03-30 2024-04-09 南通华山药业有限公司 一种阿法骨化醇杂环酯类衍生物及其制备方法
CN114681467B (zh) * 2022-03-30 2024-03-12 南通华山药业有限公司 一种阿法骨化醇杂环酯类衍生物在制备抗肿瘤药物中的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4195027A (en) * 1978-01-16 1980-03-25 Wisconsin Alumni Research Foundation Process for preparing 1α-hydroxylated compounds
US4206131A (en) * 1978-06-19 1980-06-03 The Upjohn Company Compounds and process
US4188345A (en) * 1978-07-26 1980-02-12 Wisconsin Alumni Research Foundation Fluorovitamin D compounds and processes for their preparation
JPS5846508A (ja) * 1981-09-14 1983-03-18 日本石油化学株式会社 導電性材料の製法
FR2530624B1 (fr) * 1982-07-26 1987-08-07 Wisconsin Alumni Res Found Nouveaux analogues de la vitamine d et compositions pharmaceutiques ou veterinaires les contenant
JPH0825993B2 (ja) * 1990-08-20 1996-03-13 大同ほくさん株式会社 ビタミンｄ２およびｄ３又は活性型ビタミンｄ２およびｄ３の製造方法，並びにその中間体
JPH05339230A (ja) * 1992-03-12 1993-12-21 Nisshin Flour Milling Co Ltd 活性型ビタミンｄ２及びその誘導体の製造法
JP3182215B2 (ja) * 1992-06-26 2001-07-03 日清製粉株式会社 １−アシルオキシビタミンｄ誘導体

Also Published As

Publication number Publication date
NZ501318A (en) 2001-07-27
CA2229316A1 (fr) 1997-03-27
AU7242696A (en) 1997-04-09
MX9801943A (es) 1998-08-30
NO981282L (no) 1998-05-22
KR19990063628A (ko) 1999-07-26
HUP9802303A3 (en) 1999-05-28
HUP9802303A2 (hu) 1999-02-01
EP1021401A1 (fr) 2000-07-26
NZ319819A (en) 2000-02-28
NO981282D0 (no) 1998-03-20
KR100327922B1 (ko) 2002-05-09
JPH11511475A (ja) 1999-10-05
WO1997011053A1 (fr) 1997-03-27
JP3372259B2 (ja) 2003-01-27
AU717238B2 (en) 2000-03-23

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Effective date: 20140922