CA2234585C - Liberation prolongee de facteurs stimulant les colonies de granulocytes-macrophages (gm-csf) - Google Patents
Liberation prolongee de facteurs stimulant les colonies de granulocytes-macrophages (gm-csf) Download PDFInfo
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- CA2234585C CA2234585C CA 2234585 CA2234585A CA2234585C CA 2234585 C CA2234585 C CA 2234585C CA 2234585 CA2234585 CA 2234585 CA 2234585 A CA2234585 A CA 2234585A CA 2234585 C CA2234585 C CA 2234585C
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Landscapes
- Medicinal Preparation (AREA)
Abstract
L'invention concerne des formulations permettant une libération réglée et prolongée de GM-CSF. Ces formulations sont basées sur des microparticules solides constituées de la combinaison de polymères synthétiques biodégradables tels que l'acide polylactique (PLA), l'acide polyglycolique (PLG), et leurs copolymères, avec des excipients et des charges de médicaments assurant une libération avec une cinétique d'ordre 0 ou d'ordre 1, ou encore une libération multiphase, sur une période de temps d'environ trois à vingt et un jours et, de préférence, d'une semaine, lorsque l'administration se fait par injection. Dans la forme d'exécution préférée, les microparticules sont des microsphères ayant des diamètres dans la plage allant de 10 à 60 microns, constituées d'un mélange de PLGA ayant différents poids moléculaires, de préférence 6000, 30000 et 41000. D'autres formes d'exécution ont été développées pour modifier la cinétique de libération ou la manière dont le médicament se répartit in vivo. Dans certains cas, on choisit un polymère qui provoque une réaction inflammatoire légère. Le PLGA et des polyanhydrides peuvent servir de facteur chimioattractif, soit par lui même ou par les impuretés mineures qu'il contient. D'autres polymères bioadhésifs peuvent servir à une administration transmucosale ou orale. Dans d'autres formes d'exécution, le GM-CSF est administré dans un hydrogel injecté par voie souscutanée ou en un site spécifique pour une libération réglée. Les microparticules ou l'hydrogel sont administrés au patient en une dose suffisante pour stimuler la prolifération des cellules hématopoïétiques, et en particulier des globules blancs.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA002491511A CA2491511A1 (fr) | 1995-10-12 | 1996-10-10 | Liberation prolongee de facteurs stimulant les colonies de granulocytes-macrophages (gm-csf) |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US542,445 | 1995-10-12 | ||
| US08/542,445 US5942253A (en) | 1995-10-12 | 1995-10-12 | Prolonged release of GM-CSF |
| PCT/US1996/016277 WO1997013502A2 (fr) | 1995-10-12 | 1996-10-10 | Liberation prolongee de facteurs stimulant les colonies de granulocytes-macrophages (gm-csf) |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002491511A Division CA2491511A1 (fr) | 1995-10-12 | 1996-10-10 | Liberation prolongee de facteurs stimulant les colonies de granulocytes-macrophages (gm-csf) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2234585A1 CA2234585A1 (fr) | 1997-04-17 |
| CA2234585C true CA2234585C (fr) | 2007-05-01 |
Family
ID=29405969
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2234585 Expired - Fee Related CA2234585C (fr) | 1995-10-12 | 1996-10-10 | Liberation prolongee de facteurs stimulant les colonies de granulocytes-macrophages (gm-csf) |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2234585C (fr) |
-
1996
- 1996-10-10 CA CA 2234585 patent/CA2234585C/fr not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2234585A1 (fr) | 1997-04-17 |
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| USRE50301E1 (en) | Depot systems comprising glatiramer or pharmacologically acceptable salt thereof | |
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| CA2491511A1 (fr) | Liberation prolongee de facteurs stimulant les colonies de granulocytes-macrophages (gm-csf) | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |