CA2234638C - Nouveaux complexes de bis-platine comportant des derives de polymethylene, utilises en tant que ligands dotes d'une activite antitumorale - Google Patents

Nouveaux complexes de bis-platine comportant des derives de polymethylene, utilises en tant que ligands dotes d'une activite antitumorale Download PDF

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Publication number
CA2234638C
CA2234638C CA002234638A CA2234638A CA2234638C CA 2234638 C CA2234638 C CA 2234638C CA 002234638 A CA002234638 A CA 002234638A CA 2234638 A CA2234638 A CA 2234638A CA 2234638 C CA2234638 C CA 2234638C
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CA
Canada
Prior art keywords
group
formula
protecting
iii
tert
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002234638A
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English (en)
Other versions
CA2234638A1 (fr
Inventor
Nicholas P. Farrell
Ernesto Menta
Roberto Di Domenico
Silvano Spinelli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Virginia Commonwealth University
Original Assignee
F Hoffmann La Roche AG
Virginia Commonwealth University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG, Virginia Commonwealth University filed Critical F Hoffmann La Roche AG
Priority claimed from PCT/US1997/012552 external-priority patent/WO1998003518A2/fr
Publication of CA2234638A1 publication Critical patent/CA2234638A1/fr
Application granted granted Critical
Publication of CA2234638C publication Critical patent/CA2234638C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/14—Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
    • C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
    • C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
    • C07C273/1818—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety from -N=C=O and XNR'R"
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C277/08—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/34—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfuric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA002234638A 1996-07-22 1997-07-22 Nouveaux complexes de bis-platine comportant des derives de polymethylene, utilises en tant que ligands dotes d'une activite antitumorale Expired - Lifetime CA2234638C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2226996P 1996-07-22 1996-07-22
US60/022,269 1996-07-22
PCT/US1997/012552 WO1998003518A2 (fr) 1996-07-22 1997-07-22 Nouveaux complexes de bis-platine comportant des derives de polymethylene, utilises en tant que ligands dotes d'une activite antitumorale

Publications (2)

Publication Number Publication Date
CA2234638A1 CA2234638A1 (fr) 1998-01-29
CA2234638C true CA2234638C (fr) 2006-10-03

Family

ID=37101786

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002234638A Expired - Lifetime CA2234638C (fr) 1996-07-22 1997-07-22 Nouveaux complexes de bis-platine comportant des derives de polymethylene, utilises en tant que ligands dotes d'une activite antitumorale

Country Status (1)

Country Link
CA (1) CA2234638C (fr)

Also Published As

Publication number Publication date
CA2234638A1 (fr) 1998-01-29

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