CA2236199C - Systeme sm/sm haute pression - Google Patents

Systeme sm/sm haute pression Download PDF

Info

Publication number: CA2236199C
Authority: CA; Canada
Prior art keywords: ions; mass; ion; quadrupole; multipole rod
Prior art date: 1998-04-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

CA 2236199

Other languages

English (en)

Other versions

CA2236199A1 (fr

Inventor

Gholamreza Javahery

Charles Jolliffe

Bruce Thomson

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

DH Technologies Development Pte Ltd

Original Assignee

MDS Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-28

Filing date

1998-04-28

Publication date

2006-10-03

1998-04-28 Application filed by MDS Inc filed Critical MDS Inc

1998-04-28 Priority to CA 2236199 priority Critical patent/CA2236199C/fr

1999-10-28 Publication of CA2236199A1 publication Critical patent/CA2236199A1/fr

2006-10-03 Application granted granted Critical

2006-10-03 Publication of CA2236199C publication Critical patent/CA2236199C/fr

2018-04-28 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

150000002500 ions Chemical class 0.000 claims abstract description 157
239000012634 fragment Substances 0.000 claims abstract description 24
238000000034 method Methods 0.000 claims description 41
230000005405 multipole Effects 0.000 claims description 18
238000004885 tandem mass spectrometry Methods 0.000 claims description 17
238000001514 detection method Methods 0.000 claims description 3
238000004949 mass spectrometry Methods 0.000 claims description 3
238000000926 separation method Methods 0.000 claims description 3
230000015572 biosynthetic process Effects 0.000 claims 2
238000005086 pumping Methods 0.000 abstract description 8
239000007789 gas Substances 0.000 description 15
238000013467 fragmentation Methods 0.000 description 11
238000006062 fragmentation reaction Methods 0.000 description 11
238000005040 ion trap Methods 0.000 description 10
230000010355 oscillation Effects 0.000 description 6
238000010408 sweeping Methods 0.000 description 6
230000005284 excitation Effects 0.000 description 5
239000002243 precursor Substances 0.000 description 5
238000004458 analytical method Methods 0.000 description 4
238000000065 atmospheric pressure chemical ionisation Methods 0.000 description 3
XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
230000005540 biological transmission Effects 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
230000005684 electric field Effects 0.000 description 2
239000001307 helium Substances 0.000 description 2
229910052734 helium Inorganic materials 0.000 description 2
SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 2
238000001819 mass spectrum Methods 0.000 description 2
238000001228 spectrum Methods 0.000 description 2
DNXIKVLOVZVMQF-UHFFFAOYSA-N (3beta,16beta,17alpha,18beta,20alpha)-17-hydroxy-11-methoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-yohimban-16-carboxylic acid, methyl ester Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(C(=O)OC)C(O)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 DNXIKVLOVZVMQF-UHFFFAOYSA-N 0.000 description 1
LCQMZZCPPSWADO-UHFFFAOYSA-N Reserpilin Natural products COC(=O)C1COCC2CN3CCc4c([nH]c5cc(OC)c(OC)cc45)C3CC12 LCQMZZCPPSWADO-UHFFFAOYSA-N 0.000 description 1
QEVHRUUCFGRFIF-SFWBKIHZSA-N Reserpine Natural products O=C(OC)[C@@H]1[C@H](OC)[C@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)C[C@H]2[C@@H]1C[C@H]1N(C2)CCc2c3c([nH]c12)cc(OC)cc3 QEVHRUUCFGRFIF-SFWBKIHZSA-N 0.000 description 1
230000001133 acceleration Effects 0.000 description 1
239000000654 additive Substances 0.000 description 1
230000000996 additive effect Effects 0.000 description 1
229910052786 argon Inorganic materials 0.000 description 1
239000003990 capacitor Substances 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
238000000132 electrospray ionisation Methods 0.000 description 1
238000000605 extraction Methods 0.000 description 1
230000001939 inductive effect Effects 0.000 description 1
238000002955 isolation Methods 0.000 description 1
238000002552 multiple reaction monitoring Methods 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
BJOIZNZVOZKDIG-MDEJGZGSSA-N reserpine Chemical compound O([C@H]1[C@@H]([C@H]([C@H]2C[C@@H]3C4=C([C]5C=CC(OC)=CC5=N4)CCN3C[C@H]2C1)C(=O)OC)OC)C(=O)C1=CC(OC)=C(OC)C(OC)=C1 BJOIZNZVOZKDIG-MDEJGZGSSA-N 0.000 description 1
229960003147 reserpine Drugs 0.000 description 1
MDMGHDFNKNZPAU-UHFFFAOYSA-N roserpine Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(OC(C)=O)C(OC)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 MDMGHDFNKNZPAU-UHFFFAOYSA-N 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
239000007787 solid Substances 0.000 description 1

Classifications

- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
- H01J49/4205—Device types
- H01J49/421—Mass filters, i.e. deviating unwanted ions without trapping
- H01J49/4215—Quadrupole mass filters

Landscapes

Chemical & Material Sciences (AREA)
Analytical Chemistry (AREA)
Electron Tubes For Measurement (AREA)
Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

CA 2236199 1998-04-28 1998-04-28 Systeme sm/sm haute pression Expired - Fee Related CA2236199C (fr)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
CA 2236199 CA2236199C (fr)	1998-04-28	1998-04-28	Systeme sm/sm haute pression

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CA 2236199 CA2236199C (fr)	1998-04-28	1998-04-28	Systeme sm/sm haute pression

Publications (2)

Publication Number	Publication Date
CA2236199A1 CA2236199A1 (fr)	1999-10-28
CA2236199C true CA2236199C (fr)	2006-10-03

Family

ID=29275620

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA 2236199 Expired - Fee Related CA2236199C (fr)	1998-04-28	1998-04-28	Systeme sm/sm haute pression

Country Status (1)

Country	Link
CA (1)	CA2236199C (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20250226199A1 (en) *	2021-08-30	2025-07-10	Kimia Analytics Inc.	Method and apparatus to increase sensitivity of inductively coupled plasma mass spectrometry

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2274186A1 (fr)	1999-06-10	2000-12-10	Mds Inc.	Technique d'analyse avec dissociation de collisions induites selectivement et soustraction de spectres
US20100237236A1 (en) *	2009-03-20	2010-09-23	Applera Corporation	Method Of Processing Multiple Precursor Ions In A Tandem Mass Spectrometer

1998
- 1998-04-28 CA CA 2236199 patent/CA2236199C/fr not_active Expired - Fee Related

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20250226199A1 (en) *	2021-08-30	2025-07-10	Kimia Analytics Inc.	Method and apparatus to increase sensitivity of inductively coupled plasma mass spectrometry

Also Published As

Publication number	Publication date
CA2236199A1 (fr)	1999-10-28

Legal Events

Date	Code	Title	Description
2003-01-31	EEER	Examination request
2013-06-10	MKLA	Lapsed	Effective date: 20130429

Publication	Publication Date	Title
US6093929A (en)	2000-07-25	High pressure MS/MS system
US6504148B1 (en)	2003-01-07	Quadrupole mass spectrometer with ION traps to enhance sensitivity
EP2102890B1 (fr)	2019-05-29	Analyseur de masse à piège d'ions double à pression différentielle et procédés d'utilisation de celui-ci
CA2245465C (fr)	2002-08-06	Methodes et appareils de spectroscopie de masse tandem
CA2239399C (fr)	2004-04-06	Ejection axiale dans un spectrometre de masse multipolaire
US6833544B1 (en)	2004-12-21	Method and apparatus for multiple stages of mass spectrometry
US7858926B1 (en)	2010-12-28	Mass spectrometry with segmented RF multiple ion guides in various pressure regions
US6147348A (en)	2000-11-14	Method for performing a scan function on quadrupole ion trap mass spectrometers
EP1051731B1 (fr)	2002-07-03	Procede d'analyse d'ions dans un appareil comprenant un spectrometre de masse a temps de vol et un piege a ions lineaire
CA2312754C (fr)	2007-10-09	Procede et appareil pour dissociation selective d'ions induite par collision dans un guide d'ions quadripolaire
US20030168589A1 (en)	2003-09-11	Triple quadrupole mass spectrometer with capability to perform multiple mass analysis steps
US7476853B2 (en)	2009-01-13	Ion fragmentation by reaction with neutral particles
US6787767B2 (en)	2004-09-07	Mass analyzing method using an ion trap type mass spectrometer
EP2421023A1 (fr)	2012-02-22	Spectrometrie de masse a multiples guides ioniques rf segmentes en plusieurs zones de pression
US7888634B2 (en)	2011-02-15	Method of operating a linear ion trap to provide low pressure short time high amplitude excitation
WO2020157655A1 (fr)	2020-08-06	Commande de gain automatique pour remplissage optimal de piège à ions
CA2236199C (fr)	2006-10-03	Systeme sm/sm haute pression
US6838665B2 (en)	2005-01-04	Ion trap type mass spectrometer
CA2234754A1 (fr)	1998-11-16	Spectrometre de masse pour suivre une reaction multiple et methode d'emploi

CA2236199C - Systeme sm/sm haute pression - Google Patents

Info

Links

Classifications

Landscapes

Priority Applications (1)

Applications Claiming Priority (1)

Publications (2)

Family

ID=29275620

Family Applications (1)

Country Status (1)

Cited By (1)

Families Citing this family (2)

Cited By (1)

Also Published As

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