CA2243316C - Complexes metalliques contenant du perfluoroalkyle et leur utilisation dans le diagnostic par rmn - Google Patents

Complexes metalliques contenant du perfluoroalkyle et leur utilisation dans le diagnostic par rmn Download PDF

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Publication number
CA2243316C
CA2243316C CA002243316A CA2243316A CA2243316C CA 2243316 C CA2243316 C CA 2243316C CA 002243316 A CA002243316 A CA 002243316A CA 2243316 A CA2243316 A CA 2243316A CA 2243316 C CA2243316 C CA 2243316C
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CA
Canada
Prior art keywords
general formula
compounds
mmol
meaning
added
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002243316A
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English (en)
Other versions
CA2243316A1 (fr
Inventor
Johannes Platzek
Ulrich Niedballa
Bernd Raduchel
Wolfgang Schlecker
Hanns-Joachim Weinmann
Thomas Frenzel
Bernd Misselwitz
Wolfgang Ebert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19603033A external-priority patent/DE19603033A1/de
Application filed by Schering AG filed Critical Schering AG
Publication of CA2243316A1 publication Critical patent/CA2243316A1/fr
Application granted granted Critical
Publication of CA2243316C publication Critical patent/CA2243316C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/76—Metal complexes of amino carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/10—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

L'invention concerne de nouveaux complexes métalliques monomères, à substitution perfluoroalkyle, leur procédé de préparation et leur utilisation diagnostique et thérapeutique. Ces composés sont particulièrement appropriés pour être utilisés en tant qu'agents de contraste in vivo en imagerie par résonance magnétique nucléaire. Ils peuvent être employés de préférence en tant qu'agents de marquage sanguin ("blood-pool agents") et en tant qu'agents de contraste pour la lymphographie.
CA002243316A 1996-01-19 1997-01-16 Complexes metalliques contenant du perfluoroalkyle et leur utilisation dans le diagnostic par rmn Expired - Fee Related CA2243316C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19603033A DE19603033A1 (de) 1996-01-19 1996-01-19 Perfluoralkylhaltige Metallkomplexe, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
DE19603033.1 1996-01-19
PCT/EP1997/000209 WO1997026017A2 (fr) 1996-01-19 1997-01-16 Complexes metalliques contenant du perfluoroalkyle et leur utilisation dans le diagnostic par rmn

Publications (2)

Publication Number Publication Date
CA2243316A1 CA2243316A1 (fr) 1997-07-24
CA2243316C true CA2243316C (fr) 2006-09-26

Family

ID=37057084

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002243316A Expired - Fee Related CA2243316C (fr) 1996-01-19 1997-01-16 Complexes metalliques contenant du perfluoroalkyle et leur utilisation dans le diagnostic par rmn

Country Status (1)

Country Link
CA (1) CA2243316C (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6676928B2 (en) 2000-08-11 2004-01-13 Schering Aktiengesellschaft Perfluoroalkyl-containing complexes with polar radicals, process for their production and their use

Also Published As

Publication number Publication date
CA2243316A1 (fr) 1997-07-24

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