CA2243507A1 - Inhibiteurs de la farnesyl-proteine transferase - Google Patents

Inhibiteurs de la farnesyl-proteine transferase Download PDF

Info

Publication number
CA2243507A1
CA2243507A1 CA 2243507 CA2243507A CA2243507A1 CA 2243507 A1 CA2243507 A1 CA 2243507A1 CA 2243507 CA2243507 CA 2243507 CA 2243507 A CA2243507 A CA 2243507A CA 2243507 A1 CA2243507 A1 CA 2243507A1
Authority
CA
Canada
Prior art keywords
hydrogen
alkyl
substituted
aryl
unsubstituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2243507
Other languages
English (en)
Inventor
Christopher J. Dinsmore
George D. Hartman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9605699.9A external-priority patent/GB9605699D0/en
Application filed by Individual filed Critical Individual
Publication of CA2243507A1 publication Critical patent/CA2243507A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Composés inhibants la farnésyl-protéine transférase (FTase) et la farnésylation du Ras protéique oncogène. L'invention porte en outre sur des compositions chimiothérapeutiques renfermant les composés de cette invention et sur des méthodes d'inhibitions de la farnésyl-protéine transférase et de la farnésylation du Ras protéique oncogène.
CA 2243507 1996-01-30 1997-01-27 Inhibiteurs de la farnesyl-proteine transferase Abandoned CA2243507A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US1086096P 1996-01-30 1996-01-30
US60/010,860 1996-01-30
GB9605699.9 1996-03-19
GBGB9605699.9A GB9605699D0 (en) 1996-03-19 1996-03-19 Inhibitors of farnesyl-protein transferase

Publications (1)

Publication Number Publication Date
CA2243507A1 true CA2243507A1 (fr) 1997-08-07

Family

ID=26308951

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2243507 Abandoned CA2243507A1 (fr) 1996-01-30 1997-01-27 Inhibiteurs de la farnesyl-proteine transferase

Country Status (4)

Country Link
EP (1) EP0880320A4 (fr)
AU (1) AU712504B2 (fr)
CA (1) CA2243507A1 (fr)
WO (1) WO1997027752A1 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5929250A (en) * 1997-01-23 1999-07-27 Smithkline Beecham Corporation IL-8 receptor antagonists
US6358985B1 (en) 1998-07-02 2002-03-19 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
WO2000001701A1 (fr) 1998-07-02 2000-01-13 Merck & Co., Inc. Inhibiteurs de prenyl-proteine transferase
FR2780892B1 (fr) * 1998-07-08 2001-08-17 Sod Conseils Rech Applic Utilisation d'inhibiteurs de prenyltransferases pour preparer un medicament destine a traiter les pathologies qui resultent de la fixation membranaire de la proteine g heterotrimerique
US6525069B1 (en) 1998-12-18 2003-02-25 Bristol-Myers Squibb Pharma Co. N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
EP1140087A4 (fr) 1998-12-18 2002-04-03 Du Pont Pharm Co N-ureidoalkyl-piperidines utilisees en tant que modulateurs de l'activite des recepteurs des chimiokines
US6331541B1 (en) 1998-12-18 2001-12-18 Soo S. Ko N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
US6486180B1 (en) 1998-12-18 2002-11-26 Bristol-Myers Squibb Pharma Company N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
CA2347769A1 (fr) 1998-12-18 2000-06-22 Dean A. Wacker Heterocycles 2-substitues-4-azote utilisees en tant que modulateurs de l'activite des recepteurs des chimiokines
JP2002532427A (ja) 1998-12-18 2002-10-02 デュポン ファーマシューティカルズ カンパニー ケモカイン受容体活性のモジュレーターとしてのｎ−ウレイドアルキルピペリジン
US6897234B2 (en) 1999-12-17 2005-05-24 Bristol-Myers Squibb Pharma Company N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
WO2001076694A1 (fr) 2000-04-10 2001-10-18 Merck & Co., Inc. Inhibiteurs de la prenyl-proteine transferase
DE10025782A1 (de) 2000-05-26 2001-12-06 Basf Ag Flüssigkristalline Stoffgemenge
EP1162194A1 (fr) * 2000-06-06 2001-12-12 Aventis Pharma Deutschland GmbH Dérivés de (thio)-urée inhibiteurs du facteur VIIa, procédé de leur préparation et leur utilisation
AR034257A1 (es) 2000-06-30 2004-02-18 Du Pont Pharm Co Compuesto ureido, composicion farmaceutica que lo comprende y metodo para modular la actividad del receptor de quimiocinas
AU2002326948A1 (en) 2001-09-18 2003-04-01 Bristol-Myers Squibb Company Piperizinones as modulators of chemokine receptor activity
TW200409630A (en) 2002-09-12 2004-06-16 Bristol Myers Squibb Co N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
AU2003275257A1 (en) 2002-09-26 2004-04-19 Bristol-Myers Squibb Company N-substituted heterocyclic amines as modulators of chemokine receptor activity
US7645903B2 (en) 2002-10-31 2010-01-12 Ge Healthcare Bio-Sciences Ab Use of urea variants as affinity ligands
EP2095819A1 (fr) 2008-02-28 2009-09-02 Maastricht University Dérivés de N-benzyle imidazole et leur utilisation comme inhibiteurs de l'aldosterone synthase

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4576957A (en) * 1984-07-05 1986-03-18 American Cyanamid Company N-(Substituted phenyl)-N'-[(1H-imidazol-1-yl) and (1H-1,2,4-triazol-1-yl)alkyl]ureas
CA2172125A1 (fr) * 1993-09-30 1995-04-06 S. Jane Desolms Inhibiteurs de farnesyl-proteine transferase
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
IL113196A0 (en) * 1994-03-31 1995-06-29 Bristol Myers Squibb Co Imidazole derivatives and pharmaceutical compositions containing the same
EP0783517A2 (fr) * 1994-09-29 1997-07-16 Merck & Co. Inc. Inhibiteurs de la transferase de proteines farnesylees exempts de thiol
US5756528A (en) * 1995-06-06 1998-05-26 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
CA2238081A1 (fr) * 1995-11-22 1997-05-29 S. Jane Desolms Inhibiteurs de la farnesyl-proteine transferase
JP2000504014A (ja) * 1996-01-30 2000-04-04 メルク エンド カンパニー インコーポレーテッド ファルネシル―タンパク質転移酵素の阻害剤
EP1011669A4 (fr) * 1996-01-30 2001-09-12 Merck & Co Inc Inhibiteurs de la farnesyl-proteine transferase
JP2000505797A (ja) * 1996-01-30 2000-05-16 メルク エンド カンパニー インコーポレーテッド ファルネシル―タンパク質転移酵素の阻害剤
JP2000507584A (ja) * 1996-04-03 2000-06-20 メルク エンド カンパニー インコーポレーテッド ファルネシル―タンパク質転移酵素の阻害剤
WO1997036584A1 (fr) * 1996-04-03 1997-10-09 Merck & Co., Inc. Inhibiteurs de transferase de farnesyl-proteine
EP0891353A4 (fr) * 1996-04-03 2001-08-08 Merck & Co Inc Inhibiteurs de farnesyle-proteine transferase
JP2000507955A (ja) * 1996-04-03 2000-06-27 メルク エンド カンパニー インコーポレーテッド ファルネシル―タンパク質転移酵素の阻害剤

Also Published As

Publication number Publication date
AU1851697A (en) 1997-08-22
WO1997027752A1 (fr) 1997-08-07
AU712504B2 (en) 1999-11-11
EP0880320A1 (fr) 1998-12-02
EP0880320A4 (fr) 1999-06-16

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Legal Events

Date Code Title Description
FZDE Dead