CA2244112A1 - Methode pour reduire les tumeurs du colon - Google Patents
Methode pour reduire les tumeurs du colon Download PDFInfo
- Publication number
- CA2244112A1 CA2244112A1 CA 2244112 CA2244112A CA2244112A1 CA 2244112 A1 CA2244112 A1 CA 2244112A1 CA 2244112 CA2244112 CA 2244112 CA 2244112 A CA2244112 A CA 2244112A CA 2244112 A1 CA2244112 A1 CA 2244112A1
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- CA
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- Prior art keywords
- compound
- cells
- colon cancer
- estrogen
- tumors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- SVUQHVRAGMNPLW-UHFFFAOYSA-N glycerol monostearate Natural products CCCCCCCCCCCCCCCCC(=O)OCC(O)CO SVUQHVRAGMNPLW-UHFFFAOYSA-N 0.000 description 1
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- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 1
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- CXMXRPHRNRROMY-UHFFFAOYSA-L sebacate(2-) Chemical compound [O-]C(=O)CCCCCCCCC([O-])=O CXMXRPHRNRROMY-UHFFFAOYSA-L 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000011684 sodium molybdate Substances 0.000 description 1
- 235000015393 sodium molybdate Nutrition 0.000 description 1
- TVXXNOYZHKPKGW-UHFFFAOYSA-N sodium molybdate (anhydrous) Chemical compound [Na+].[Na+].[O-][Mo]([O-])(=O)=O TVXXNOYZHKPKGW-UHFFFAOYSA-N 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
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- 239000000758 substrate Substances 0.000 description 1
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- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000007916 tablet composition Substances 0.000 description 1
- KKEYFWRCBNTPAC-UHFFFAOYSA-L terephthalate(2-) Chemical compound [O-]C(=O)C1=CC=C(C([O-])=O)C=C1 KKEYFWRCBNTPAC-UHFFFAOYSA-L 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 229940071104 xylenesulfonate Drugs 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'invention concerne une méthode pour réduire les tumeurs du colon consistant à administrer à un mammifère nécessitant un tel traitement, une dose suffisante pour être efficace, d'un composé ayant la formule (I). Dans cette formule, R?1¿ et R?3¿ sont, d'une manière indépendante, un hydrogène, -CH¿3?, (a) ou (b), où Ar est un phényle, éventuellement substitué, R?2¿ est choisi dans le groupe constitué par pyrrolidine, hexaméthylèneimino ou pipéridino. L'invention concerne également un sel ou un solvate de ces composés, acceptable sur le plan pharmaceutique.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1077296P | 1996-01-29 | 1996-01-29 | |
| US60/010,772 | 1996-01-29 | ||
| US60315096A | 1996-02-15 | 1996-02-15 | |
| US9603150.5 | 1996-02-15 | ||
| PCT/US1997/002286 WO1997026877A1 (fr) | 1996-01-29 | 1997-01-27 | Methode pour reduire les tumeurs du colon |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2244112A1 true CA2244112A1 (fr) | 1997-07-31 |
Family
ID=29424295
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2244112 Abandoned CA2244112A1 (fr) | 1996-01-29 | 1997-01-27 | Methode pour reduire les tumeurs du colon |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2244112A1 (fr) |
-
1997
- 1997-01-27 CA CA 2244112 patent/CA2244112A1/fr not_active Abandoned
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Dead |