CA2245165A1 - Sensibilisation aux substances chimiotherapeutiques des cellules cancereuses surexprimant her2/neu - Google Patents

Sensibilisation aux substances chimiotherapeutiques des cellules cancereuses surexprimant her2/neu Download PDF

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Publication number
CA2245165A1
CA2245165A1 CA002245165A CA2245165A CA2245165A1 CA 2245165 A1 CA2245165 A1 CA 2245165A1 CA 002245165 A CA002245165 A CA 002245165A CA 2245165 A CA2245165 A CA 2245165A CA 2245165 A1 CA2245165 A1 CA 2245165A1
Authority
CA
Canada
Prior art keywords
emodin
tyrosine kinase
cells
neu
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002245165A
Other languages
English (en)
Inventor
Mien-Chie Hung
Lisha Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2245165A1 publication Critical patent/CA2245165A1/fr
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Méthodes d'inhibition du produit génétique du neu oncogène p185neu tyrosine kinase. La surexpression du neu oncogène conduit à la chimiorésistance. Les méthodes présentées reposent sur l'utilisation nouvelle de l'émodine en association avec des substances chimiothérapeutiques servant à traiter le carcinome. En outre, l'émodine renforce les effets antinéoplasiques des agents chimiothérapeutiques, ce qui n'était pas connu. Selon l'invention, l'émodine sensibilise les cellules cancéreuses pour les rendre sensibles aux traitements par les substances chimiothérapeutiques.
CA002245165A 1996-01-31 1997-01-31 Sensibilisation aux substances chimiotherapeutiques des cellules cancereuses surexprimant her2/neu Abandoned CA2245165A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1087596P 1996-01-31 1996-01-31
US60/010,875 1996-01-31

Publications (1)

Publication Number Publication Date
CA2245165A1 true CA2245165A1 (fr) 1997-08-07

Family

ID=21747830

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002245165A Abandoned CA2245165A1 (fr) 1996-01-31 1997-01-31 Sensibilisation aux substances chimiotherapeutiques des cellules cancereuses surexprimant her2/neu

Country Status (5)

Country Link
EP (1) EP0877608A1 (fr)
JP (1) JP2000504020A (fr)
AU (1) AU1854597A (fr)
CA (1) CA2245165A1 (fr)
WO (1) WO1997027848A1 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6326356B1 (en) 1996-10-18 2001-12-04 Board Of Regents, The University Of Texas System Suppression of neu overexpression using a mini-E1A gene
US6685940B2 (en) 1995-07-27 2004-02-03 Genentech, Inc. Protein formulation
US6267958B1 (en) 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
US7371376B1 (en) 1996-10-18 2008-05-13 Genentech, Inc. Anti-ErbB2 antibodies
EP1027045A4 (fr) * 1997-10-31 2004-12-08 Arch Dev Corp Procedes et compositions pour reguler l'activite de la 5-alpha-reductase
US6949245B1 (en) 1999-06-25 2005-09-27 Genentech, Inc. Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies
US7041292B1 (en) 1999-06-25 2006-05-09 Genentech, Inc. Treating prostate cancer with anti-ErbB2 antibodies
KR20110008112A (ko) 1999-08-27 2011-01-25 제넨테크, 인크. 항-ＥｒｂＢ2 항체 투여 치료 방법
US20040138160A1 (en) * 2001-04-27 2004-07-15 Kenichiro Naito Preventive/therapeutic method for cancer
US20040116330A1 (en) * 2001-04-27 2004-06-17 Kenichiro Naito Preventive/therapeutic method for cancer
CA2635310C (fr) 2006-04-07 2013-05-14 Sunten Phytotech Co., Ltd. Composes d'anthracenedione
JPWO2007132784A1 (ja) * 2006-05-15 2009-09-24 国立大学法人 新潟大学 アントラキノン誘導体を有効成分として含有する抗精神病薬、認知異常の治療薬
JP2011520921A (ja) * 2008-05-16 2011-07-21 ファルマ・マール・ソシエダード・アノニマ 抗腫瘍アルカロイドとの併用療法
US8541382B2 (en) * 2010-11-13 2013-09-24 Sirbal Ltd. Cardiac glycoside analogs in combination with emodin for cancer therapy
RU2693004C1 (ru) * 2019-03-15 2019-07-01 Лейсан Фаридовна Минигулова Противоопухолевая композиция цисплатина с ингибитором 6-фосфоглюконатдегидрогеназы

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4966918A (en) * 1989-01-27 1990-10-30 Sloan-Kettering Institute For Cancer Research Derivatives of chryosphanol
US5436243A (en) * 1993-11-17 1995-07-25 Research Triangle Institute Duke University Aminoanthraquinone derivatives to combat multidrug resistance

Also Published As

Publication number Publication date
WO1997027848A1 (fr) 1997-08-07
EP0877608A1 (fr) 1998-11-18
AU1854597A (en) 1997-08-22
JP2000504020A (ja) 2000-04-04

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