CA2245804C - Proteines de ribonuclease de recombinaison - Google Patents

Proteines de ribonuclease de recombinaison Download PDF

Info

Publication number
CA2245804C
CA2245804C CA002245804A CA2245804A CA2245804C CA 2245804 C CA2245804 C CA 2245804C CA 002245804 A CA002245804 A CA 002245804A CA 2245804 A CA2245804 A CA 2245804A CA 2245804 C CA2245804 C CA 2245804C
Authority
CA
Canada
Prior art keywords
lys
ser
thr
met
asn
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002245804A
Other languages
English (en)
Other versions
CA2245804A1 (fr
Inventor
Susanna M. Rybak
Dianne L. Newton
Lluis Boque
Alexander Wlodawer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Health and Human Services
Original Assignee
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Department of Health and Human Services filed Critical US Department of Health and Human Services
Priority claimed from PCT/US1997/002588 external-priority patent/WO1997031116A2/fr
Publication of CA2245804A1 publication Critical patent/CA2245804A1/fr
Application granted granted Critical
Publication of CA2245804C publication Critical patent/CA2245804C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/463—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from amphibians
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002245804A 1996-02-21 1997-02-19 Proteines de ribonuclease de recombinaison Expired - Fee Related CA2245804C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1180096P 1996-02-21 1996-02-21
US60/011,800 1996-02-21
PCT/US1997/002588 WO1997031116A2 (fr) 1996-02-21 1997-02-19 Proteines de ribonuclease de recombinaison

Publications (2)

Publication Number Publication Date
CA2245804A1 CA2245804A1 (fr) 1997-08-28
CA2245804C true CA2245804C (fr) 2007-01-23

Family

ID=37684472

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002245804A Expired - Fee Related CA2245804C (fr) 1996-02-21 1997-02-19 Proteines de ribonuclease de recombinaison

Country Status (1)

Country Link
CA (1) CA2245804C (fr)

Also Published As

Publication number Publication date
CA2245804A1 (fr) 1997-08-28

Similar Documents

Publication Publication Date Title
AU2021211348B2 (en) Novel hyaluronic acid-hydrolyzing enzyme variant having improved stability and pharmaceutical composition comprising same
EP0896625B1 (fr) Proteines de ribonuclease de recombinaison
AU752370B2 (en) Utilization of wolinella succinogenes asparaginase to treat diseases associated with asparagine dependence
US6045793A (en) Recombinant ribonuclease proteins
US6649393B1 (en) Mutant form of cytotoxic ribonucleolytic protein which allows production by recombinant methods
US7052689B2 (en) Method for producing therapeutically suitable glutaminase
Saxena et al. ONCONASE® and its therapeutic potential
US20030099629A1 (en) Recombinant onconase and chemical conjugates and fusion proteins of recombinant onconase
CA2346127A1 (fr) Nouvelle desoxyribonuclease, gene codant cette derniere, et procede de production de cette derniere
CA2245804C (fr) Proteines de ribonuclease de recombinaison
US6869604B1 (en) Recombinant anti-tumor RNAse
EP1068332B1 (fr) Ribonuclease antitumorale recombinee
EP1062348B1 (fr) Onconase recombinante et proteines de fusion de l'onconase recombinante
AU773347B2 (en) Recombinant anti-tumor RNASE
US6991788B1 (en) Utilization of wolinella succinogenes asparaginase to treat diseases associated with asparagine dependence
CA2401916A1 (fr) Ribonuclease antitumorale recombinee
EP1219706A2 (fr) Procédé de préparation d' asparaginase recombinée à partir de Wolinella succinogenes
EP1277838A1 (fr) RNAse anti tumorale recombinante
EP1854876A2 (fr) Glutaminase créée génétiquement et son utilisation dans le cadre d'une thérapie antivirale et anticancer
HK1110891A (en) Genetically engineered glutaminase and its use in antiviral and anticancer therapy
JP2004141169A (ja) 遺伝学的に操作されたグルタミナーゼ、および抗ウイルスと抗ガン治療におけるその使用

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed