CA2246033A1 - Agent therapeutique pour disque intervertebral hernie - Google Patents

Agent therapeutique pour disque intervertebral hernie

Info

Publication number
CA2246033A1
CA2246033A1 CA002246033A CA2246033A CA2246033A1 CA 2246033 A1 CA2246033 A1 CA 2246033A1 CA 002246033 A CA002246033 A CA 002246033A CA 2246033 A CA2246033 A CA 2246033A CA 2246033 A1 CA2246033 A1 CA 2246033A1
Authority
CA
Canada
Prior art keywords
intervertebral disc
herniated intervertebral
pharmaceutical composition
degrading enzyme
chondroitinase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002246033A
Other languages
English (en)
Other versions
CA2246033C (fr
Inventor
Yutaka Nohara
Hiroki Ishikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Seikagaku Corp
Original Assignee
Seikagaku Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Seikagaku Corp filed Critical Seikagaku Corp
Publication of CA2246033A1 publication Critical patent/CA2246033A1/fr
Application granted granted Critical
Publication of CA2246033C publication Critical patent/CA2246033C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/51—Lyases (4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA2246033A 1997-08-22 1998-08-21 Agent therapeutique pour disque intervertebral hernie Expired - Fee Related CA2246033C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP9-226872 1997-08-22
JP22687297 1997-08-22

Publications (2)

Publication Number Publication Date
CA2246033A1 true CA2246033A1 (fr) 1999-02-22
CA2246033C CA2246033C (fr) 2012-12-04

Family

ID=16851905

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2246033A Expired - Fee Related CA2246033C (fr) 1997-08-22 1998-08-21 Agent therapeutique pour disque intervertebral hernie

Country Status (9)

Country Link
US (1) US6063378A (fr)
EP (1) EP0900569B1 (fr)
AT (1) ATE225184T1 (fr)
AU (1) AU735216B2 (fr)
CA (1) CA2246033C (fr)
DE (1) DE69808402T2 (fr)
DK (1) DK0900569T3 (fr)
ES (1) ES2185117T3 (fr)
RU (1) RU2209080C2 (fr)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA01003538A (es) * 1998-10-06 2005-09-08 Rush Presbyterian St Luke Metodo para el tratamiento de quimionucleolisis.
US6783546B2 (en) 1999-09-13 2004-08-31 Keraplast Technologies, Ltd. Implantable prosthetic or tissue expanding device
US6371984B1 (en) 1999-09-13 2002-04-16 Keraplast Technologies, Ltd. Implantable prosthetic or tissue expanding device
US7615076B2 (en) 1999-10-20 2009-11-10 Anulex Technologies, Inc. Method and apparatus for the treatment of the intervertebral disc annulus
US7052516B2 (en) 1999-10-20 2006-05-30 Anulex Technologies, Inc. Spinal disc annulus reconstruction method and deformable spinal disc annulus stent
US6592625B2 (en) 1999-10-20 2003-07-15 Anulex Technologies, Inc. Spinal disc annulus reconstruction method and spinal disc annulus stent
US8632590B2 (en) 1999-10-20 2014-01-21 Anulex Technologies, Inc. Apparatus and methods for the treatment of the intervertebral disc
US7004970B2 (en) 1999-10-20 2006-02-28 Anulex Technologies, Inc. Methods and devices for spinal disc annulus reconstruction and repair
US8128698B2 (en) 1999-10-20 2012-03-06 Anulex Technologies, Inc. Method and apparatus for the treatment of the intervertebral disc annulus
US7935147B2 (en) 1999-10-20 2011-05-03 Anulex Technologies, Inc. Method and apparatus for enhanced delivery of treatment device to the intervertebral disc annulus
US7951201B2 (en) 1999-10-20 2011-05-31 Anulex Technologies, Inc. Method and apparatus for the treatment of the intervertebral disc annulus
US6805695B2 (en) 2000-04-04 2004-10-19 Spinalabs, Llc Devices and methods for annular repair of intervertebral discs
US20030069639A1 (en) * 2001-04-14 2003-04-10 Tom Sander Methods and compositions for repair or replacement of joints and soft tissues
WO2003037166A2 (fr) * 2001-11-01 2003-05-08 Boyd Lawrence M Dispositifs et procedes de restauration de disque rachidien
EP1465521A4 (fr) * 2001-11-01 2008-10-08 Spine Wave Inc Systeme et methode de pretraitement des plaques motrices d'un disque intervertebral
EP2301564A1 (fr) * 2002-05-04 2011-03-30 Acorda Therapeutics, Inc. Compositions et methodes visant a favoriser l'excroissance neuronale
DE60334220D1 (de) * 2002-06-03 2010-10-28 Massachusetts Inst Technology Rationell konstruierte, von chondroitinase b abgeleitete lyasen
US7163545B2 (en) * 2002-07-29 2007-01-16 Mayo Foundation For Medical Education And Research Spinal cord surgical implant
US20060153827A1 (en) * 2002-08-15 2006-07-13 Gruskin Elliott A Chimeric protein
WO2004097022A1 (fr) * 2003-03-31 2004-11-11 Seikagaku Corporation Catalyseur pour le clivage d'une chaine de sucres
EP3514238B1 (fr) 2003-05-16 2021-05-05 Acorda Therapeutics, Inc. Mutants de dégradation de protéoglycane pour le traitement du système nerveux central
US7959914B2 (en) 2003-05-16 2011-06-14 Acorda Therapeutics, Inc. Methods of reducing extravasation of inflammatory cells
JP4754492B2 (ja) * 2003-05-16 2011-08-24 アコーダ セラピューティクス、インク． 中枢神経系障害を治療するための組成物および方法
US7169405B2 (en) * 2003-08-06 2007-01-30 Warsaw Orthopedic, Inc. Methods and devices for the treatment of intervertebral discs
JP4440939B2 (ja) 2004-01-08 2010-03-24 スパイン・ウェイブ・インコーポレーテッド 伸延した組織部位に流動性材料を注入する装置及び方法
US8226941B2 (en) * 2004-05-18 2012-07-24 Acorda Therapeutics, Inc. Methods of purifying chondroitinase and stable formulations thereof
WO2006004887A2 (fr) * 2004-06-29 2006-01-12 Spine Wave, Inc. Procedes de traitement de defauts et de lesions sur disque intervertebral
US9968120B2 (en) * 2006-05-17 2018-05-15 Dsm Nutritional Products Ag Homogenized formulations containing microcapsules and methods of making and using thereof
JP5189985B2 (ja) 2005-09-26 2013-04-24 アコーダ セラピューティクス、インク． コンドロイチナーゼａｂｃｉ変異体を用いた組成物およびその使用方法
US7771414B2 (en) * 2006-04-24 2010-08-10 Warsaw Orthopedic, Inc. Controlled release devices for therapeutic treatments of spinal discs
US8642059B2 (en) 2006-04-24 2014-02-04 Warsaw Orthopedic, Inc. Controlled release systems and methods for intervertebral discs
US8642060B2 (en) * 2006-04-24 2014-02-04 Warsaw Orthopedic, Inc. Controlled release systems and methods for osteal growth
US7879027B2 (en) * 2006-04-24 2011-02-01 Warsaw Orthopedic, Inc. Controlled release devices for fusion of osteal structures
US7722864B2 (en) 2006-10-10 2010-05-25 Acorda Therapeutics, Inc. Compositions and methods of using chondroitinase ABCI mutants
US8163022B2 (en) 2008-10-14 2012-04-24 Anulex Technologies, Inc. Method and apparatus for the treatment of the intervertebral disc annulus
US8460319B2 (en) 2010-01-11 2013-06-11 Anulex Technologies, Inc. Intervertebral disc annulus repair system and method
NZ605873A (en) 2010-06-25 2015-02-27 Shire Human Genetic Therapies Methods and compositions for cns delivery of arylsulfatase a
NZ605874A (en) 2010-06-25 2015-02-27 Shire Human Genetic Therapies Methods and compositions for cns delivery of heparan n-sulfatase
CN103179980B (zh) * 2010-06-25 2016-09-28 夏尔人类遗传性治疗公司 艾杜糖醛酸-2-硫酸酯酶的cns递送的方法和组合物
SMT201600385T1 (it) 2010-06-25 2017-03-08 Shire Human Genetic Therapies Trasporto di agenti terapeutici all’snc
RS62620B1 (sr) 2010-06-25 2021-12-31 Shire Human Genetic Therapies Metode i kompozicije za isporuku cns akrilsulfataze a
TWI488641B (zh) 2010-12-13 2015-06-21 生化學工業股份有限公司 椎間盤突出治療劑
US20140377244A1 (en) 2011-12-23 2014-12-25 Shire Human Genetic Therapies, Inc. Stable formulations for cns delivery of arylsulfatase a
AU2014209124A1 (en) 2013-01-28 2015-09-17 Cartiva, Inc. Systems and methods for orthopedic repair
US9737294B2 (en) 2013-01-28 2017-08-22 Cartiva, Inc. Method and system for orthopedic repair
JP6587675B2 (ja) * 2014-03-20 2019-10-09 ステイブル セラピューティクス アーベー 椎間板性疼痛の治療での使用のための組成物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4696816A (en) * 1985-11-07 1987-09-29 Brown Mark D Method for treating intervertebral disc displacement with enzymes
RU2021812C1 (ru) * 1992-04-13 1994-10-30 Всесоюзный научно-исследовательский институт технологии кровезаменителей и гормональных препаратов Средство для лечения артрологических заболеваний
US5496718A (en) * 1992-06-26 1996-03-05 Seikagaku Kogyo Kabushiki Kaisha (Seikagaku Corporation) Chondroitinase ABC isolated from proteus vulgaris ATCC 6896
JP3419811B2 (ja) * 1993-02-24 2003-06-23 マルハ株式会社 コンドロイチナーゼ遺伝子
US6228998B1 (en) * 1994-07-22 2001-05-08 Seikagaku Kogyo Kabushiki Kaisha Amino spacered glycosaminoglycan derivatives and their use in copolymerization with acrylamide
EP0875253B1 (fr) * 1997-05-02 2005-04-06 Seikagaku Corporation Compositionsde chondroitinase

Also Published As

Publication number Publication date
EP0900569A2 (fr) 1999-03-10
AU735216B2 (en) 2001-07-05
AU8082698A (en) 1999-03-04
DK0900569T3 (da) 2003-01-27
RU2209080C2 (ru) 2003-07-27
EP0900569A3 (fr) 1999-04-07
DE69808402D1 (de) 2002-11-07
ES2185117T3 (es) 2003-04-16
CA2246033C (fr) 2012-12-04
US6063378A (en) 2000-05-16
DE69808402T2 (de) 2003-07-03
ATE225184T1 (de) 2002-10-15
EP0900569B1 (fr) 2002-10-02

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20180821