CA2270118A1 - Composes nitroses et nitrosyles inhibiteurs de la phosphodiesterase, compositions comprenant ces composes et utilisations correspondantes - Google Patents

Composes nitroses et nitrosyles inhibiteurs de la phosphodiesterase, compositions comprenant ces composes et utilisations correspondantes Download PDF

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Publication number
CA2270118A1
CA2270118A1 CA002270118A CA2270118A CA2270118A1 CA 2270118 A1 CA2270118 A1 CA 2270118A1 CA 002270118 A CA002270118 A CA 002270118A CA 2270118 A CA2270118 A CA 2270118A CA 2270118 A1 CA2270118 A1 CA 2270118A1
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CA
Canada
Prior art keywords
compound
formula
defined above
group
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002270118A
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English (en)
Inventor
David S. Garvey
Inigo Saenz De Tejada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nitromed Inc
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Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/740,764 external-priority patent/US5874437A/en
Application filed by Individual filed Critical Individual
Publication of CA2270118A1 publication Critical patent/CA2270118A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gynecology & Obstetrics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Paper (AREA)
  • Cosmetics (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne des inhibiteurs nitrosés et/ou nitrosylés de la phosphodiestérase, l'inhibiteur étant représenté par la formule NO¿n?-PDE dans laquelle "n" vaut 1 ou 2. Un tel inhibiteur de la phosphodiestérase peut être nitrosé ou nitrosylé par des sites tels que l'oxygène (condensation hydroxyl), le soufre (condensation sulfhydryl), le carbone et de l'azote. L'invention concerne également des compositions comprenant de tels composés associés à un excipient pharmaceutiquement admis. L'invention concerne par ailleurs une composition comprenant une quantité thérapeutiquement active d'un inhibiteur de la phosphodiestérase (inhibiteur PDE) qui peut être éventuellement substitué par un ou plusieurs groupes fonctionnels NO ou NO¿2? et un excédant molaire de un à dix fois d'un composé qui donne, transfère ou libère du monoxyde d'azote sous forme d'espèce chargée, en l'occurrence de nitrosinium (NO?+¿) ou de nitroxyl (NO?-¿), ou sous forme d'espèce neutre, en l'occurrence l'oxyde nitrique (NO?.¿), qui stimule la production endogène d'EDRF. L'invention concerne en outre des compositions intégrant de tels composés dans un excipient pharmaceutiquement admis. L'invention concerne enfin un traitement dirigé contre l'impuissance masculine et consistant à administrer ces composés et des compositions à base de tels composés.
CA002270118A 1996-11-01 1997-10-31 Composes nitroses et nitrosyles inhibiteurs de la phosphodiesterase, compositions comprenant ces composes et utilisations correspondantes Abandoned CA2270118A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/740,764 US5874437A (en) 1996-11-01 1996-11-01 Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
US08/740,764 1996-11-01
PCT/US1997/019870 WO1998019672A1 (fr) 1996-11-01 1997-10-31 Composes nitroses et nitrosyles inhibiteurs de la phosphodiesterase, compositions comprenant ces composes et utilisations correspondantes

Publications (1)

Publication Number Publication Date
CA2270118A1 true CA2270118A1 (fr) 1998-05-14

Family

ID=26792881

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002270118A Abandoned CA2270118A1 (fr) 1996-11-01 1997-10-31 Composes nitroses et nitrosyles inhibiteurs de la phosphodiesterase, compositions comprenant ces composes et utilisations correspondantes

Country Status (5)

Country Link
EP (1) EP0941086A4 (fr)
JP (1) JP2001504457A (fr)
AU (1) AU722480B2 (fr)
CA (1) CA2270118A1 (fr)
WO (1) WO1998019672A1 (fr)

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US6331543B1 (en) 1996-11-01 2001-12-18 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
USRE37234E1 (en) * 1996-11-01 2001-06-19 Nitromed, Inc. Nitrosated and nitrosylated phosphodiestrase inhibitor compounds, compositions and their uses
US5958926A (en) 1996-11-01 1999-09-28 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
EP1535611A3 (fr) * 1997-06-23 2009-09-16 Strakan International Limited Thérapie de conditions vasculaires par des microdoses de doneurs de NO
JP2003525845A (ja) * 1997-10-28 2003-09-02 ヴィヴァス・インコーポレイテッド 勃起機能不全の処置のためのホスホジエステラーゼインヒビターの局所投与
US6472425B1 (en) 1997-10-31 2002-10-29 Nitromed, Inc. Methods for treating female sexual dysfunctions
US6200591B1 (en) 1998-06-25 2001-03-13 Anwar A. Hussain Method of administration of sildenafil to produce instantaneous response for the treatment of erectile dysfunction
BR9916162A (pt) * 1998-12-14 2001-09-04 Cellegy Pharma Inc Composição e método para o tratamento de um distúrbio anorretal e para controlar a dor associada com o mesmo
US6627632B2 (en) 1998-12-14 2003-09-30 Cellegy Pharmaceuticals, Inc. Compositions and methods for the treatment of anorectal disorders
US6476037B1 (en) * 2000-03-23 2002-11-05 The Regents Of The University Of California L-arginine and phosphodiesterase (PDE) inhibitor synergism
AU2000270300A1 (en) * 2000-09-13 2002-03-26 Isis Innovation Limited Use of phosphodiesterase inhibitors for the treatment of anorectal disorders
WO2002087508A2 (fr) 2001-05-02 2002-11-07 Nitromed, Inc. Nebivolol nitrose et nitrosylate et ses metabolites, compositions et techniques d'utilisation
DE60230266D1 (de) * 2001-06-15 2009-01-22 Astellas Pharma Inc Phenylpyridincarbonyl piperazinderivate
NZ532310A (en) 2001-10-05 2007-02-23 Combinatorx Inc Combinations comprising a tetra-substituted pyrimidopyrimidine and a corticosteroid for the treatment of immunoinflammatory disorders
TW200517114A (en) 2003-10-15 2005-06-01 Combinatorx Inc Methods and reagents for the treatment of immunoinflammatory disorders
US7875268B2 (en) 2004-04-06 2011-01-25 L'oreal S.A. Dimercaptoamides, compositions comprising them as reducing agents, and processes for permanently reshaping keratin fibers therewith
US7067659B2 (en) * 2004-04-23 2006-06-27 Duke University Reactive oxygen generating enzyme inhibitor with nitric oxide bioactivity and uses thereof
ATE462703T1 (de) 2004-08-25 2010-04-15 Actelion Pharmaceuticals Ltd Bicyclononen-derivate als renin-inhibitoren
WO2006041855A2 (fr) 2004-10-04 2006-04-20 Nitromed, Inc. Compositions et procedes faisant intervenir des composes apocynine et des donneurs d'oxyde nitrique
GEP20115206B (en) 2005-05-27 2011-04-26 Actelion Pharmaceuticals Ltd Novel piperidine carboxylic acid amide derivatives
EP1915157A4 (fr) 2005-08-02 2010-09-01 Nicox Sa Composes antimicrobiens promoteurs d'oxyde nitrique, compositions et procedes d'utilisation
NZ570828A (en) 2006-02-02 2011-07-29 Actelion Pharmaceuticals Ltd Secondary amines as renin inhibitors
AU2007243765A1 (en) 2006-03-29 2007-11-08 Nicox S.A. Nitric oxide enhancing prostaglandin compounds, compositions and methods of use
KR101403311B1 (ko) 2008-05-05 2014-06-05 액테리온 파마슈티칼 리미티드 레닌 억제제로서의 3,4-치환된 피페리딘 유도체
NO2440239T3 (fr) 2009-06-09 2018-02-10
MX2019013626A (es) * 2017-05-22 2020-01-13 Topadur Pharma Ag Modo de accion dual novedoso de activadores de guanilato ciclasa solubles e inhibidores de fosfodiesterasa y usos de los mismos.
WO2022022669A1 (fr) * 2020-07-30 2022-02-03 Biofront Therapeutics (Beijing) Co., Ltd. Composés à double fonction et leurs procédés d'utilisation
CA3187693A1 (fr) * 2020-07-30 2022-02-03 Zheng Huang Conjugues de medicament comprenant de l'apremilast et un groupe oxyde nitrique, et utilisations connexes
WO2023005180A1 (fr) * 2021-07-30 2023-02-02 Biofront Therapeutics (Beijing) Co., Ltd. Composés à double fonction et leurs procédés d'utilisation

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU179019B (en) * 1978-11-01 1982-08-28 Gyogyszekutato Intezet Process for preparing 4-//3,4-dialkoxy-phenyl/-alkyl/- 2imidazolidinone derivatives
US5459145A (en) * 1988-01-19 1995-10-17 Pfizer Inc. Calcium independent camp phosphodiesterase inhibitor antidepressant
US4714705A (en) * 1986-07-07 1987-12-22 Ortho Pharmaceutical Corporation 4-nitrogen substituted isoquinolinol compounds having cardiotonic, phosphodiesterase fraction III inhibiting properties and/or renal vasodilating properties
GB8817651D0 (en) * 1988-07-25 1988-09-01 Smith Kline French Lab Chemical compounds
GB8928346D0 (en) * 1989-12-15 1990-02-21 Smith Kline French Lab Chemical compounds
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GB9013750D0 (en) * 1990-06-20 1990-08-08 Pfizer Ltd Therapeutic agents
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GB9608408D0 (en) * 1996-04-23 1996-06-26 Adams Michael A Treatment of erectile dysfunction

Also Published As

Publication number Publication date
EP0941086A4 (fr) 2000-07-12
AU5196298A (en) 1998-05-29
EP0941086A1 (fr) 1999-09-15
JP2001504457A (ja) 2001-04-03
AU722480B2 (en) 2000-08-03
WO1998019672A1 (fr) 1998-05-14

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US5958926A (en) Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
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EP1852422A2 (fr) Composés antagonistes des récepteurs alpha-andrénergiques nitrosés et nitrosylés, compositions et leurs utilisations
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Legal Events

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EEER Examination request
FZDE Dead