CA2270413A1 - Procede et appareil de purification du plasma sanguin - Google Patents
Procede et appareil de purification du plasma sanguin Download PDFInfo
- Publication number
- CA2270413A1 CA2270413A1 CA002270413A CA2270413A CA2270413A1 CA 2270413 A1 CA2270413 A1 CA 2270413A1 CA 002270413 A CA002270413 A CA 002270413A CA 2270413 A CA2270413 A CA 2270413A CA 2270413 A1 CA2270413 A1 CA 2270413A1
- Authority
- CA
- Canada
- Prior art keywords
- filter
- pore size
- nominal pore
- membrane
- microporous membrane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 210000002381 plasma Anatomy 0.000 title claims abstract description 73
- 238000000034 method Methods 0.000 title claims abstract description 22
- 239000012528 membrane Substances 0.000 claims abstract description 87
- 239000011148 porous material Substances 0.000 claims abstract description 64
- 210000000265 leukocyte Anatomy 0.000 claims abstract description 61
- 239000012982 microporous membrane Substances 0.000 claims abstract description 28
- 238000011045 prefiltration Methods 0.000 claims description 41
- 238000001914 filtration Methods 0.000 claims description 17
- 238000007789 sealing Methods 0.000 claims description 15
- 230000002209 hydrophobic effect Effects 0.000 claims description 8
- 210000003743 erythrocyte Anatomy 0.000 claims description 6
- 239000011152 fibreglass Substances 0.000 claims description 6
- 230000000717 retained effect Effects 0.000 claims description 6
- 229910001385 heavy metal Inorganic materials 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 150000002500 ions Chemical class 0.000 claims 1
- 239000004576 sand Substances 0.000 claims 1
- 210000004379 membrane Anatomy 0.000 description 66
- 238000012360 testing method Methods 0.000 description 9
- 239000000463 material Substances 0.000 description 7
- 229920000642 polymer Polymers 0.000 description 6
- 230000013011 mating Effects 0.000 description 5
- -1 polytetrafluoroethylene Polymers 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 4
- 239000012678 infectious agent Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 239000004695 Polyether sulfone Substances 0.000 description 3
- 239000004743 Polypropylene Substances 0.000 description 3
- 241000700605 Viruses Species 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 230000001186 cumulative effect Effects 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 230000005484 gravity Effects 0.000 description 3
- 208000006454 hepatitis Diseases 0.000 description 3
- 231100000283 hepatitis Toxicity 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 229920006393 polyether sulfone Polymers 0.000 description 3
- 229920001155 polypropylene Polymers 0.000 description 3
- 238000003466 welding Methods 0.000 description 3
- 102000009027 Albumins Human genes 0.000 description 2
- 108010088751 Albumins Proteins 0.000 description 2
- 239000004677 Nylon Substances 0.000 description 2
- 239000012888 bovine serum Substances 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 239000000356 contaminant Substances 0.000 description 2
- 239000003792 electrolyte Substances 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 210000003714 granulocyte Anatomy 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 210000002652 macrocyte Anatomy 0.000 description 2
- 229920002521 macromolecule Polymers 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 229920001778 nylon Polymers 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 229920000728 polyester Polymers 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 230000000630 rising effect Effects 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 229920001169 thermoplastic Polymers 0.000 description 2
- 239000004416 thermosoftening plastic Substances 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 230000032258 transport Effects 0.000 description 2
- 101100536354 Drosophila melanogaster tant gene Proteins 0.000 description 1
- 208000005189 Embolism Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000001690 Factor VIII Human genes 0.000 description 1
- 108010054218 Factor VIII Proteins 0.000 description 1
- 102000008946 Fibrinogen Human genes 0.000 description 1
- 108010049003 Fibrinogen Proteins 0.000 description 1
- 208000031220 Hemophilia Diseases 0.000 description 1
- 208000009292 Hemophilia A Diseases 0.000 description 1
- 241000271915 Hydrophis Species 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 239000002033 PVDF binder Substances 0.000 description 1
- 241000282320 Panthera leo Species 0.000 description 1
- 102000007584 Prealbumin Human genes 0.000 description 1
- 108010071690 Prealbumin Proteins 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 229920006020 amorphous polyamide Polymers 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 229960000301 factor viii Drugs 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 229940012952 fibrinogen Drugs 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000012213 gelatinous substance Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000003365 glass fiber Substances 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 230000001524 infective effect Effects 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 239000013627 low molecular weight specie Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 229920002492 poly(sulfone) Polymers 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 229920002981 polyvinylidene fluoride Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- NQLVQOSNDJXLKG-UHFFFAOYSA-N prosulfocarb Chemical compound CCCN(CCC)C(=O)SCC1=CC=CC=C1 NQLVQOSNDJXLKG-UHFFFAOYSA-N 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000003206 sterilizing agent Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000004634 thermosetting polymer Substances 0.000 description 1
- 229920001187 thermosetting polymer Polymers 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000005199 ultracentrifugation Methods 0.000 description 1
- 241001430294 unidentified retrovirus Species 0.000 description 1
- 238000013022 venting Methods 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
- B01D69/12—Composite membranes; Ultra-thin membranes
- B01D69/1216—Three or more layers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3627—Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
- A61M1/3633—Blood component filters, e.g. leukocyte filters
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/18—Apparatus therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
- B01D63/08—Flat membrane modules
- B01D63/081—Manufacturing thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
- B01D63/08—Flat membrane modules
- B01D63/089—Modules where the membrane is in the form of a bag, membrane cushion or pad
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
- A61M2202/0415—Plasma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
- A61M2202/0439—White blood cells; Leucocytes
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Water Supply & Treatment (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Anesthesiology (AREA)
- Manufacturing & Machinery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- External Artificial Organs (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
La présente invention concerne un procédé et un dispositif de purification du plasma sanguin traités selon les techniques conventionnelles. Cette purification vise à éliminer sensiblement tous les leucocytes résiduels tout en conservant des débits utiles convenant au traitement de quantités de plasma médicalement utiles. A cet effet, on emploie un filtre jetable thermo-stérilisable (1) mettant en oeuvre, dans une enveloppe commune, un ou plusieurs préfiltres en épaisseur (29) et au moins une membrane hydrophile microporeuse intermédiaire (25a) suivie d'au moins une membrane hydrophile microporeuse finale (25b) dont le calibre des pores est inférieur au calibre des pores de la membrane intermédiaire.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74594896A | 1996-11-08 | 1996-11-08 | |
| US08/745,948 | 1996-11-08 | ||
| US84116397A | 1997-04-29 | 1997-04-29 | |
| US08/841,163 | 1997-04-29 | ||
| PCT/US1997/019908 WO1998019722A1 (fr) | 1996-11-08 | 1997-11-05 | Procede et appareil de purification du plasma sanguin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2270413A1 true CA2270413A1 (fr) | 1998-05-14 |
Family
ID=27114539
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002270413A Abandoned CA2270413A1 (fr) | 1996-11-08 | 1997-11-05 | Procede et appareil de purification du plasma sanguin |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0938351A1 (fr) |
| JP (1) | JP2001503656A (fr) |
| CN (1) | CN1122536C (fr) |
| AU (1) | AU722640B2 (fr) |
| CA (1) | CA2270413A1 (fr) |
| NO (1) | NO992162L (fr) |
| WO (1) | WO1998019722A1 (fr) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010037978A1 (en) * | 1999-04-20 | 2001-11-08 | Daryl R. Calhoun | Filter assembly having a flexible housing and method of making same |
| FR2777786B1 (fr) * | 1998-04-27 | 2000-08-11 | Maco Pharma Sa | Poche de filtration destinee a retenir par filtration les constituants cellulaires du plasma,ensemble de poches la contenant. |
| AU763879B2 (en) * | 1998-10-02 | 2003-07-31 | Pall Corporation | Biological fluid filter and system |
| FR2802116B1 (fr) | 1999-12-10 | 2002-05-03 | Maco Pharma Sa | Unite de filtration sterile d'un fluide,notamment le sang |
| CN1420796A (zh) | 2000-03-31 | 2003-05-28 | 巴克斯特国际公司 | 收集包括不含或实质上不含血细胞的血浆在内的减白细胞的血液组分的系统及方法 |
| FR2835752B1 (fr) * | 2002-02-13 | 2004-11-26 | Maco Pharma Sa | Unite de filtration comprenant des couches deleucocytantes calandrees |
| DE10304365A1 (de) * | 2003-02-04 | 2004-08-05 | Ls-Medcap Gmbh | Filtervorrichtung |
| EP1506808A1 (fr) * | 2003-07-31 | 2005-02-16 | Teva Medical Ltd. | Filtre a leucocytes et mode d'utilisation |
| GB0809092D0 (en) | 2008-05-20 | 2008-06-25 | Univ Strathclyde | Fluid processing device |
| CA2766670C (fr) | 2009-11-17 | 2018-07-10 | Brightwake Limited | Dispositif et procede pour traiter un fluide |
| CN102821795B (zh) * | 2010-03-30 | 2015-09-23 | 旭化成医疗株式会社 | 血液处理过滤器 |
| TWI498135B (zh) * | 2012-04-12 | 2015-09-01 | Univ Nat Cheng Kung | 液體樣本過濾裝置 |
| CN113559585B (zh) | 2015-03-20 | 2023-04-28 | 马林科学发展公司 | 高流量低阻延过滤器 |
| CN105445083B (zh) * | 2015-12-21 | 2018-09-11 | 丹娜(天津)生物科技有限公司 | 免离心全血处理模块 |
| LT3471808T (lt) * | 2016-06-21 | 2022-04-11 | Sedana Medical Limited | Sedacijos prietaisas |
| CN116744986A (zh) * | 2020-12-25 | 2023-09-12 | 广州倍绣生物技术有限公司 | 纤维蛋白原除菌过滤 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3876738A (en) | 1973-07-18 | 1975-04-08 | Amf Inc | Process for producing microporous films and products |
| ZA792326B (en) | 1978-05-15 | 1980-06-25 | Pall Corp | Process for preparing polyamide membrane filter media and product |
| IL58787A0 (en) * | 1978-12-21 | 1980-02-29 | Baxter Travenol Lab | Disposable filter cell for membrane plasmapheresis |
| US4673504A (en) | 1980-10-27 | 1987-06-16 | Cuno Inc. | Charge modified microporous membrane |
| US4473474A (en) | 1980-10-27 | 1984-09-25 | Amf Inc. | Charge modified microporous membrane, process for charge modifying said membrane and process for filtration of fluid |
| US4711793A (en) | 1980-10-27 | 1987-12-08 | Cuno Incorporated | Process for charge modifying a microphorous membrane |
| US4708803A (en) | 1980-10-27 | 1987-11-24 | Cuno Incorporated | Liquid filtration using hydrophilic cationic isotropic microporous nylon membrane |
| US4900449A (en) | 1987-05-20 | 1990-02-13 | Gelman Sciences | Filtration membranes and method of making the same |
| US5108607A (en) | 1987-05-20 | 1992-04-28 | Gelman Sciences, Inc. | Filtration membranes and method of making the same |
| US4964990A (en) | 1987-05-20 | 1990-10-23 | Gelman Sciences, Inc. | Filtration membranes and method of making the same |
| US5423989A (en) * | 1988-05-19 | 1995-06-13 | Chemtrack, Inc. | Plasma forming device |
| US5076935A (en) | 1990-05-31 | 1991-12-31 | Gelman Sciences, Inc. | Filtration membranes made from polyethersulfone/phenoxy resin blend |
| EP0554460B1 (fr) * | 1991-08-22 | 2000-11-15 | Asahi Medical Co., Ltd. | MILIEU FILTRANT POUR l'ELIMINATION SELECTIVE DE LEUCOCYTES ET DISPOSITIF GARNI DE CELUI-CI |
-
1997
- 1997-11-05 AU AU50059/97A patent/AU722640B2/en not_active Ceased
- 1997-11-05 WO PCT/US1997/019908 patent/WO1998019722A1/fr not_active Ceased
- 1997-11-05 CA CA002270413A patent/CA2270413A1/fr not_active Abandoned
- 1997-11-05 EP EP97913002A patent/EP0938351A1/fr not_active Withdrawn
- 1997-11-05 JP JP52163498A patent/JP2001503656A/ja active Pending
- 1997-11-05 CN CN97181290A patent/CN1122536C/zh not_active Expired - Fee Related
-
1999
- 1999-05-04 NO NO992162A patent/NO992162L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU5005997A (en) | 1998-05-29 |
| CN1122536C (zh) | 2003-10-01 |
| JP2001503656A (ja) | 2001-03-21 |
| NO992162L (no) | 1999-07-06 |
| AU722640B2 (en) | 2000-08-10 |
| CN1248171A (zh) | 2000-03-22 |
| WO1998019722A1 (fr) | 1998-05-14 |
| EP0938351A1 (fr) | 1999-09-01 |
| NO992162D0 (no) | 1999-05-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |