CA2273622C - Inhibition de la signalisation induite par le recepteur nmda dans le but de reduire les lesions neuronales - Google Patents

Inhibition de la signalisation induite par le recepteur nmda dans le but de reduire les lesions neuronales Download PDF

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Publication number
CA2273622C
CA2273622C CA2273622A CA2273622A CA2273622C CA 2273622 C CA2273622 C CA 2273622C CA 2273622 A CA2273622 A CA 2273622A CA 2273622 A CA2273622 A CA 2273622A CA 2273622 C CA2273622 C CA 2273622C
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CA
Canada
Prior art keywords
peptide
tsxv
motif
containing peptide
excitotoxicity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2273622A
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English (en)
Other versions
CA2273622A1 (fr
Inventor
Michael Tymianski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NoNO Inc
Original Assignee
NoNO Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NoNO Inc filed Critical NoNO Inc
Priority to CA2273622A priority Critical patent/CA2273622C/fr
Publication of CA2273622A1 publication Critical patent/CA2273622A1/fr
Priority to US10/208,374 priority patent/US7595297B2/en
Priority to US10/930,192 priority patent/US7510824B2/en
Priority to US11/894,818 priority patent/US7846897B2/en
Priority to US12/392,988 priority patent/US8071548B2/en
Priority to US12/557,884 priority patent/US8648043B2/en
Priority to US13/286,071 priority patent/US20120302504A1/en
Application granted granted Critical
Publication of CA2273622C publication Critical patent/CA2273622C/fr
Priority to US14/279,243 priority patent/US20150190459A1/en
Priority to US15/292,062 priority patent/US20170239316A1/en
Priority to US15/956,563 priority patent/US20180369319A1/en
Anticipated expiration legal-status Critical
Priority to US16/578,318 priority patent/US20200222492A1/en
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2273622A 1999-06-02 1999-06-02 Inhibition de la signalisation induite par le recepteur nmda dans le but de reduire les lesions neuronales Expired - Lifetime CA2273622C (fr)

Priority Applications (11)

Application Number Priority Date Filing Date Title
CA2273622A CA2273622C (fr) 1999-06-02 1999-06-02 Inhibition de la signalisation induite par le recepteur nmda dans le but de reduire les lesions neuronales
US10/208,374 US7595297B2 (en) 1999-06-02 2002-07-30 Method of reducing injury to mammalian cells
US10/930,192 US7510824B2 (en) 1999-06-02 2004-08-31 Method of screening peptides useful in treating traumatic injury to the brain or spinal cord
US11/894,818 US7846897B2 (en) 1999-06-02 2007-08-20 Agents for reducing injury to mammalian cells
US12/392,988 US8071548B2 (en) 1999-06-02 2009-02-25 Method of reducing injury to mammalian cells
US12/557,884 US8648043B2 (en) 1999-06-02 2009-09-11 Method of reducing injury to mammalian cells
US13/286,071 US20120302504A1 (en) 1999-06-02 2011-10-31 Method Of Reducing Injury To Mammalian Cells
US14/279,243 US20150190459A1 (en) 1999-06-02 2014-05-15 Method Of Reducing Injury To Mammalian Cells
US15/292,062 US20170239316A1 (en) 1999-06-02 2016-10-12 Method Of Reducing Injury To Mammalian Cells
US15/956,563 US20180369319A1 (en) 1999-06-02 2018-04-18 Method of Reducing Injury to Mammalian Cells
US16/578,318 US20200222492A1 (en) 1999-06-02 2019-09-21 Method of Reducing Injury to Mammalian Cells

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA2273622A CA2273622C (fr) 1999-06-02 1999-06-02 Inhibition de la signalisation induite par le recepteur nmda dans le but de reduire les lesions neuronales

Publications (2)

Publication Number Publication Date
CA2273622A1 CA2273622A1 (fr) 2000-12-02
CA2273622C true CA2273622C (fr) 2012-03-20

Family

ID=30774266

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2273622A Expired - Lifetime CA2273622C (fr) 1999-06-02 1999-06-02 Inhibition de la signalisation induite par le recepteur nmda dans le but de reduire les lesions neuronales

Country Status (1)

Country Link
CA (1) CA2273622C (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6942981B1 (en) 1999-05-14 2005-09-13 Arbor Vita Corporation Method of determining interactions with PDZ-domain polypeptides
AU5011200A (en) * 1999-05-14 2000-12-05 Arbor Vita Corporation Molecular interactions in hematopoietic cells
US7595297B2 (en) 1999-06-02 2009-09-29 Michael Tymianski Method of reducing injury to mammalian cells
US7510824B2 (en) 1999-06-02 2009-03-31 Nono Inc. Method of screening peptides useful in treating traumatic injury to the brain or spinal cord
WO2001087285A2 (fr) * 2000-05-12 2001-11-22 The Johns Hopkins University Inhibition de l'interaction de l'antisens psd93 et psd95 avec des recepteurs de nnos et nmda
US20020045590A1 (en) 2000-10-23 2002-04-18 Yuanxiang Tao Inhibition of interaction of PSD93 and PSD95 with nNOS and NMDA receptors
CA2505479A1 (fr) * 2002-11-14 2004-06-03 Arbor Vita Corporation Interactions moleculaires dans des neurones

Also Published As

Publication number Publication date
CA2273622A1 (fr) 2000-12-02

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Effective date: 20190603