CA2274896A1 - Procede de fabrication de derives de d-proline - Google Patents

Procede de fabrication de derives de d-proline Download PDF

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Publication number
CA2274896A1
CA2274896A1 CA002274896A CA2274896A CA2274896A1 CA 2274896 A1 CA2274896 A1 CA 2274896A1 CA 002274896 A CA002274896 A CA 002274896A CA 2274896 A CA2274896 A CA 2274896A CA 2274896 A1 CA2274896 A1 CA 2274896A1
Authority
CA
Canada
Prior art keywords
proline
general formula
derivative
proline derivative
microorganisms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002274896A
Other languages
English (en)
Inventor
Oleg Werbitzky
Daniel Venetz
Martin Sauter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lonza AG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2274896A1 publication Critical patent/CA2274896A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/24—Proline; Hydroxyproline; Histidine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention concerne de nouveaux micro-organismes qui sont capables d'utiliser un dérivé de proline, sous sa forme racémate ou de son isomère optiquement actif, de formule générale (I), dans laquelle R?1¿ désigne un alkyle, un acyle ou un hydrogène, R?2¿ désigne un hydrogène ou un hydroxy, et R?3¿ désigne -NH¿2?, un aryloxy ou un alkoxy, comme unique source d'azote, comme unique source de carbone ou comme unique source de carbone et d'azote. Ces micro-organismes sont utilisés pour de nouveaux procédés de fabrication de dérivés de D-proline.
CA002274896A 1996-12-16 1997-12-12 Procede de fabrication de derives de d-proline Abandoned CA2274896A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH3080/96 1996-12-16
CH308096 1996-12-16
PCT/EP1997/007006 WO1998027222A1 (fr) 1996-12-16 1997-12-12 Procede de fabrication de derives de d-proline

Publications (1)

Publication Number Publication Date
CA2274896A1 true CA2274896A1 (fr) 1998-06-25

Family

ID=4248188

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002274896A Abandoned CA2274896A1 (fr) 1996-12-16 1997-12-12 Procede de fabrication de derives de d-proline

Country Status (6)

Country Link
EP (1) EP0944730A1 (fr)
JP (1) JP2001506500A (fr)
AU (1) AU5757498A (fr)
CA (1) CA2274896A1 (fr)
CZ (1) CZ213199A3 (fr)
WO (1) WO1998027222A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220154240A1 (en) * 2019-02-27 2022-05-19 Guang An Mojia Biotechnology Co., Ltd. Method for resolving optical isomer by means of electrodialysis technique

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004295187A1 (en) * 2003-12-04 2005-06-16 Pfizer Inc. Methods for the preparation of stereoisomerically enriched amines

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5840473B2 (ja) * 1978-06-29 1983-09-06 財団法人野田産業科学研究所 新規なプロリンアシラ−ゼ及びその製法
JPS5571491A (en) * 1978-11-24 1980-05-29 Noda Sangyo Kagaku Kenkyusho Preparation of proline acylase
JPH06740B2 (ja) * 1984-08-16 1994-01-05 三菱レイヨン株式会社 光学活性カルボン酸アミドの製造法
JPH0783712B2 (ja) * 1987-09-18 1995-09-13 ダイセル化学工業株式会社 新規なプロリンアシラーゼ及びその製造法
DE3929570A1 (de) * 1989-09-06 1991-03-07 Degussa Mikrobiologisch hergestellte n-acyl-l-prolin-acylase, verfahren zu ihrer gewinnung und ihre verwendung
CA2150526C (fr) * 1994-06-09 2005-11-15 Andreas Kiener Procede biotechnologique de preparation d'acides s-.alpha.-aminocarboxyliques et r-.alpha.-aminocarboxamides cycliques
CA2245543A1 (fr) * 1996-03-13 1997-09-18 Fabienne Henzen Procede de preparation de derives de d-proline proteges en 8

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220154240A1 (en) * 2019-02-27 2022-05-19 Guang An Mojia Biotechnology Co., Ltd. Method for resolving optical isomer by means of electrodialysis technique

Also Published As

Publication number Publication date
CZ213199A3 (cs) 1999-11-17
EP0944730A1 (fr) 1999-09-29
JP2001506500A (ja) 2001-05-22
AU5757498A (en) 1998-07-15
WO1998027222A1 (fr) 1998-06-25

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Legal Events

Date Code Title Description
FZDE Discontinued