CA2281085A1 - Emploi d'une nouvelle desintegrine metalloprotease, ses mutants, fragments, etc - Google Patents

Emploi d'une nouvelle desintegrine metalloprotease, ses mutants, fragments, etc Download PDF

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Publication number
CA2281085A1
CA2281085A1 CA002281085A CA2281085A CA2281085A1 CA 2281085 A1 CA2281085 A1 CA 2281085A1 CA 002281085 A CA002281085 A CA 002281085A CA 2281085 A CA2281085 A CA 2281085A CA 2281085 A1 CA2281085 A1 CA 2281085A1
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CA
Canada
Prior art keywords
ser
gly
lys
leu
arg
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002281085A
Other languages
English (en)
Inventor
Michael Howard Tindal
Tariq Mehmood Haqqi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Case Western Reserve University
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1997/003217 external-priority patent/WO1997031931A1/fr
Application filed by Case Western Reserve University, Procter and Gamble Co filed Critical Case Western Reserve University
Publication of CA2281085A1 publication Critical patent/CA2281085A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La présente invention concerne un procédé permettant d'identifier des composés susceptibles de se fixer à la protéine disintégrine, et de déterminer la quantité et l'affinité d'un composé susceptible de se fixer à la protéine disintégrine dans un échantillon. L'invention concerne également une cellule hôte contenant un vecteur d'expression recombinant à la protéine disintégrine et un vecteur d'expression recombinant codant la protéine disintégrine, la protéine humaine métalloprotéase disintégrine, son mutant et son fragment. Ladite cellule est utilisée pour répondre aux objectifs de la présente invention. L'invention concerne enfin un procédé in vivo ou in vitro, qui permet de dépister l'ostéo-arthrite dégénérative et d'autres maladies provoquées par la métalloprotéase, et est susceptible d'être fabriqué et utilisé sous la forme d'un kit.
CA002281085A 1997-02-25 1998-02-25 Emploi d'une nouvelle desintegrine metalloprotease, ses mutants, fragments, etc Abandoned CA2281085A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US81015397A 1997-02-25 1997-02-25
US08/810,153 1997-02-25
PCT/US1997/003217 WO1997031931A1 (fr) 1996-03-01 1997-02-28 Nouvelle disintegrine-metalloprotease et procedes d'utilisation
USPCT/US97/03217 1997-02-28
PCT/US1998/003490 WO1998037092A2 (fr) 1997-02-25 1998-02-25 Utilisation d'une nouvelle proteine metalloprotease disintegrine, mutants, fragments et analogues de ladite proteine

Publications (1)

Publication Number Publication Date
CA2281085A1 true CA2281085A1 (fr) 1998-08-27

Family

ID=26792372

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002281085A Abandoned CA2281085A1 (fr) 1997-02-25 1998-02-25 Emploi d'une nouvelle desintegrine metalloprotease, ses mutants, fragments, etc

Country Status (7)

Country Link
EP (1) EP0977775A2 (fr)
JP (1) JP2001514494A (fr)
AU (1) AU6181798A (fr)
CA (1) CA2281085A1 (fr)
HU (1) HUP0100780A2 (fr)
NO (1) NO994056L (fr)
WO (1) WO1998037092A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6436629B1 (en) 2000-10-27 2002-08-20 The Regents Of The University Of California Modulating angiogenesis
JP7581619B2 (ja) * 2019-12-20 2024-11-13 横河電機株式会社 新規創薬スクリーニング方法、新規創薬スクリーニングシステム、及び新規創薬スクリーニング制御装置

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL122305A0 (en) * 1995-06-08 1998-04-05 Immunex Corp Tace polypeptide its production and its use
KR19990087444A (ko) * 1996-03-01 1999-12-27 케이스 웨스턴 리저브 유니버시티 신규 디스인테그린 메탈로프로테아제 및 이의 사용법

Also Published As

Publication number Publication date
WO1998037092A2 (fr) 1998-08-27
NO994056D0 (no) 1999-08-23
HUP0100780A2 (hu) 2001-06-28
NO994056L (no) 1999-10-25
WO1998037092A3 (fr) 1998-11-05
JP2001514494A (ja) 2001-09-11
EP0977775A2 (fr) 2000-02-09
AU6181798A (en) 1998-09-09

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued