CA2283929C - Procede permettant de traiter un mal de tete a l'aide de compositions anesthesiques topiques - Google Patents

Procede permettant de traiter un mal de tete a l'aide de compositions anesthesiques topiques Download PDF

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Publication number
CA2283929C
CA2283929C CA002283929A CA2283929A CA2283929C CA 2283929 C CA2283929 C CA 2283929C CA 002283929 A CA002283929 A CA 002283929A CA 2283929 A CA2283929 A CA 2283929A CA 2283929 C CA2283929 C CA 2283929C
Authority
CA
Canada
Prior art keywords
local anesthetic
composition
topical
headache pain
eucalyptol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002283929A
Other languages
English (en)
Other versions
CA2283929A1 (fr
Inventor
Larry J. Caldwell
Bradley Stuart Galer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nuvo Research Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority claimed from PCT/US1997/008378 external-priority patent/WO1998052567A1/fr
Publication of CA2283929A1 publication Critical patent/CA2283929A1/fr
Application granted granted Critical
Publication of CA2283929C publication Critical patent/CA2283929C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne des procédés permettant de traiter une personne souffrant d'un mal de tête par applications topiques d'un anesthésique local. La composition d'anesthésique topique comprend une quantité efficace d'un anesthésique local combiné avec de l'eucalyptol, en tant qu'agent favorisant la pénétration, et éventuellement avec un autre agent favorisant la pénétration. La composition anesthésique topique est appliquée sur une région de la peau kératinisée proche des nerfs cibles associés au mal de tête, en général proche des régions sus-orbitaire et occipitale. Lorsque l'on applique la composition topique, l'anesthésique local pénètre rapidement dans la peau pour bloquer la conduction dans les nerfs cibles et supprimer ainsi la douleur de la personne.
CA002283929A 1997-05-20 1997-05-20 Procede permettant de traiter un mal de tete a l'aide de compositions anesthesiques topiques Expired - Fee Related CA2283929C (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1997/008378 WO1998052567A1 (fr) 1995-10-30 1997-05-20 Procede permettant de traiter un mal de tete a l'aide de compositions anesthesiques topiques

Publications (2)

Publication Number Publication Date
CA2283929A1 CA2283929A1 (fr) 1998-11-26
CA2283929C true CA2283929C (fr) 2007-02-20

Family

ID=22260919

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002283929A Expired - Fee Related CA2283929C (fr) 1997-05-20 1997-05-20 Procede permettant de traiter un mal de tete a l'aide de compositions anesthesiques topiques

Country Status (3)

Country Link
JP (1) JP2001512415A (fr)
AU (1) AU727736B2 (fr)
CA (1) CA2283929C (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7169633B2 (ja) * 2018-08-31 2022-11-11 国立大学法人山口大学 表面麻酔剤

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5748159A (en) * 1980-09-03 1982-03-19 Sharp Corp Electronic interpreter
US4440777A (en) * 1981-07-07 1984-04-03 Merck & Co., Inc. Use of eucalyptol for enhancing skin permeation of bio-affecting agents
FR2754256B1 (fr) * 1996-10-08 1998-12-24 Union Pharma Scient Appl Nouveaux derives 1,2-diarylmethylenes, leurs procedes de preparation, et leurs utilisations en therapeutique

Also Published As

Publication number Publication date
CA2283929A1 (fr) 1998-11-26
AU3130097A (en) 1998-12-11
JP2001512415A (ja) 2001-08-21
AU727736B2 (en) 2000-12-21

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20140521