CA2286511A1 - Derives de macrolides nouveaux - Google Patents

Derives de macrolides nouveaux Download PDF

Info

Publication number
CA2286511A1
CA2286511A1 CA002286511A CA2286511A CA2286511A1 CA 2286511 A1 CA2286511 A1 CA 2286511A1 CA 002286511 A CA002286511 A CA 002286511A CA 2286511 A CA2286511 A CA 2286511A CA 2286511 A1 CA2286511 A1 CA 2286511A1
Authority
CA
Canada
Prior art keywords
formula
compounds
macrolide derivatives
novel macrolide
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002286511A
Other languages
English (en)
Other versions
CA2286511C (fr
Inventor
Brian Scott Bronk
Hengmiao Cheng
Jason Kenneth Dutra
Michael Anthony Letavic
Robert John Rafka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Products Inc
Original Assignee
Pfizer Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc filed Critical Pfizer Products Inc
Publication of CA2286511A1 publication Critical patent/CA2286511A1/fr
Application granted granted Critical
Publication of CA2286511C publication Critical patent/CA2286511C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CA002286511A 1998-10-09 1999-10-07 Derives de macrolides nouveaux Expired - Fee Related CA2286511C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10383898P 1998-10-09 1998-10-09
US60/103,838 1998-10-09

Publications (2)

Publication Number Publication Date
CA2286511A1 true CA2286511A1 (fr) 2000-04-09
CA2286511C CA2286511C (fr) 2003-07-08

Family

ID=22297279

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002286511A Expired - Fee Related CA2286511C (fr) 1998-10-09 1999-10-07 Derives de macrolides nouveaux

Country Status (10)

Country Link
US (1) US6100240A (fr)
EP (1) EP0992509B1 (fr)
JP (1) JP3679656B2 (fr)
AT (1) ATE277062T1 (fr)
BR (1) BR9905089A (fr)
CA (1) CA2286511C (fr)
DE (1) DE69920362T2 (fr)
DK (1) DK0992509T3 (fr)
ES (1) ES2226294T3 (fr)
PT (1) PT992509E (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6339063B1 (en) 1997-09-10 2002-01-15 Merck & Co., Inc. 9a-azalides as veterinary antimicrobial agents
EP1779853A3 (fr) * 1997-09-10 2010-01-27 Merial Ltd. 9a-azalides en tant qu'agents anti-microbiens à usage vétérinaire
ATE353014T1 (de) * 1997-09-10 2007-02-15 Merial Ltd Verwendung von 9a-azaliden als antimikrobielle mittel für tiere
AP1060A (en) * 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
AP9801420A0 (en) * 1998-01-02 1998-12-31 Pfizer Prod Inc Novel macrolides.
AP2001002222A0 (en) * 1999-01-27 2001-09-30 Pfizer Prod Inc Ketolide antibiotics.
CA2292359C (fr) * 1999-01-28 2004-09-28 Pfizer Products Inc. Nouveaux azalides et procede de fabrication
US6939861B2 (en) 1999-04-16 2005-09-06 Kosan Biosciences, Inc. Amido macrolides
IL145739A0 (en) * 1999-05-24 2002-07-25 Pfizer Prod Inc 13-methyl-erythromycin derivatives
US6420535B1 (en) * 1999-06-07 2002-07-16 Abbott Laboratories 6-O-carbamate ketolide derivatives
AU4269301A (en) * 2000-04-27 2001-11-07 Pfizer Products Inc. The use of azalide antibiotic compositions for treating or preventing a bacterial or protozoal infection in mammals
CA2471383A1 (fr) * 2002-01-17 2003-07-31 Yandong Li Amido-macrolides
EP1483579A4 (fr) 2002-02-15 2006-07-12 Merckle Gmbh Conjugues de composes biologiquement actifs, methodes de preparation et d'utilisation des conjugues, formulation et applications pharmaceutiques obtenues a partir desdits conjugues
WO2003070174A2 (fr) 2002-02-15 2003-08-28 Sympore Gmbh Conjugues de composes biologiquement actifs, procedes de preparation et d'utilisation, et formulation et applications pharmaceutiques
WO2003070254A1 (fr) 2002-02-15 2003-08-28 Sympore Gmbh Conjugues antibiotiques
CN101423539B (zh) * 2008-12-09 2011-04-27 山东大学 4″,11-二氨基甲酸酯阿奇霉素衍生物、制备方法及其药物组合物
CN103965273B (zh) 2013-08-23 2016-05-25 普莱柯生物工程股份有限公司 一种大环内酯类化合物
CN105669798B (zh) * 2013-08-23 2019-07-26 普莱柯生物工程股份有限公司 一种大环内酯类化合物
CN109535211B (zh) * 2018-12-19 2020-05-08 江苏威凌生化科技有限公司 一种合成纯化泰拉霉素杂质c的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5441939A (en) * 1994-03-04 1995-08-15 Pfizer Inc. 3"-desmethoxy derivatives of erythromycin and azithromycin
US5641753A (en) * 1996-03-25 1997-06-24 Chris E. Platt 10-AZA-9-deoxo-11-deoxy-erythromycin A and derivatives combined with sulfisoxazole
HN1998000086A (es) * 1997-06-11 1999-03-08 Pfizer Prod Inc Derivados de 9 - desofo - 9 aza - 9a - homoeritromicina a - c - 4 sustituidos.
HN1998000074A (es) * 1997-06-11 1999-01-08 Pfizer Prod Inc Derivados de macrolidos c-4 sustituidos

Also Published As

Publication number Publication date
US6100240A (en) 2000-08-08
ATE277062T1 (de) 2004-10-15
DE69920362D1 (de) 2004-10-28
DK0992509T3 (da) 2004-12-20
EP0992509B1 (fr) 2004-09-22
DE69920362T2 (de) 2006-02-09
JP2000119294A (ja) 2000-04-25
JP3679656B2 (ja) 2005-08-03
EP0992509A2 (fr) 2000-04-12
BR9905089A (pt) 2000-08-08
PT992509E (pt) 2004-12-31
EP0992509A3 (fr) 2001-03-07
ES2226294T3 (es) 2005-03-16
CA2286511C (fr) 2003-07-08

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